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Onnimikki writes James Stewart, author of the calculus textbooks many of us either loved or loved to hate, has died. In case you ever wondered what the textbook was funding, this story has the answer: a $32 million dollar home over-looking a ravine in Toronto, Canada.
159 comments | yesterday
An anonymous reader writes with this quote from Quanta Magazine:
Most genetic research to date has focused on just 1 percent of the genome — the areas that code for proteins. But new research, published today in Science, provides an initial map for the sections of the genome that orchestrate this protein-building process. "It's one thing to have the book — the big question is how you read the book," said Brendan Frey, a computational biologist at the University of Toronto who led the new research (abstract).
For example, researchers can use the model to predict what will happen to a protein when there’s a mistake in part of the regulatory code. Mutations in splicing instructions have already been linked to diseases such as spinal muscular atrophy, a leading cause of infant death, and some forms of colorectal cancer. In the new study, researchers used the trained model to analyze genetic data from people afflicted with some of those diseases. The scientists identified some known mutations linked to these maladies, verifying that the model works. They picked out some new candidate mutations as well, most notably for autism.
One of the benefits of the model, Frey said, is that it wasn’t trained using disease data, so it should work on any disease or trait of interest. The researchers plan to make the system publicly available, which means that scientists will be able to apply it to many more diseases.
13 comments | yesterday
astroengine writes NASA's Kepler space telescope has detected its first new extrasolar planet after mission engineers were able to save the mission from a premature death after two of the exoplanet hunter's four stabilizing reaction wheels failed last year. Called "K2," the extended mission arose from an "innovative idea" that appears to have given the prolific telescope a new lease on life. "Last summer, the possibility of a scientifically productive mission for Kepler after its reaction wheel failure in its extended mission was not part of the conversation," said Paul Hertz, NASA's astrophysics division director at the agency's headquarters in Washington D.C. "Today, thanks to an innovative idea and lots of hard work by the NASA and Ball Aerospace team, Kepler may well deliver the first candidates for follow-up study by the James Webb Space Telescope to characterize the atmospheres of distant worlds and search for signatures of life."
27 comments | yesterday
v3rgEz writes In a terse form letter responding to a FOIA request, the FBI has confirmed it has an open investigation into Gamergate, the loose but controversial coalition of gamers calling for ethics in gaming journalism — even as some members have harassed and sent death threats to female gaming developers and critics.
532 comments | 2 days ago
HughPickens.com writes: Lex Berko reports in The Atlantic that although webcasting has been around since the mid-1990s, livestreamed funerals have only begun to go mainstream in the last few years. The National Funeral Directors Association has only this year introduced a new funeral webcasting license that permits funeral homes to legally webcast funerals that include copyrighted music. The webcast service's growing appeal is, by all accounts, a result of the increasing mobility of modern society. Remote participation is often the only option for those who live far away or have other barriers — financial, temporal, health-related — barring them from attending a funeral. "It's not designed to replace folks attending funerals," says Walker Posey. "A lot of folks just don't live where their family grew up and it's difficult to get back and forth."
But some funeral directors question if online funerals are helpful to the grieving process and eschew streaming funerals live because they do not want to replace a communal human experience with a solitary digital one. What happens if there's a technical problem with the webcast — will we grieve even more knowing we missed the service in person and online? Does webcasting bode well for the future of death acceptance, or does it only promote of our further alienation from that inevitable moment? "The physical dead body is proof of death, tangible evidence that the person we love is gone, and that we will someday be gone as well," says Caitlin Doughty, a death theorist and mortician. "To have death and mourning transferred online takes away that tangible proof. What is there to show us that death is real?"
70 comments | 4 days ago
An anonymous reader writes Google [on Friday] announced it plans to retire the Google Earth API on December 12, 2015. The reason is simple: Both Chrome and Firefox are removing support for Netscape Plugin Application Programming Interface (NPAPI) plugins due to security reasons, so the API's death was inevitable. The timing makes sense. Last month, Google updated its plan for killing off NPAPI support in Chrome, saying that it would block all plugins by default in January and drop support completely in September. The company also revealed that the Google Earth plugin had dropped in usage from 9.1 percent of Chrome users in October 2013 to 0.1 percent in October 2014. Add dwindling cross-platform support (particularly on mobile devices), and we're frankly surprised the announcement didn't come sooner.
75 comments | about a week ago
An anonymous reader writes Andy Baio, aka @waxpancake, indy video game enthusiast and founder of the XOXO conference and other cool stuff, conducted a weird/cool experiment on his four-year-old. Andy taught him about gaming by making him play and master all of the old video games and gaming systems in the exact order they were actually released. In other words, this 21st century kid learned gaming the same way the generation that grew up in the 1970s and 1980s experienced them, but in compressed time. From the article: "This approach to widely surveying classic games clearly had an impact on him, and influenced the games that he likes now. Like seemingly every kid his age, he loves Minecraft. No surprises there. But he also loves brutally difficult games that challenge gamers 2–3 times his age, and he’s frighteningly good at them. His favorites usually borrow characteristics from roguelikes: procedurally-generated levels, permanent death, no save points."
222 comments | about two weeks ago
HughPickens.com writes Donald McNeil writes in the NYT that this year's flu season may be deadlier than usual because this year's flu vaccine is a relatively poor match to a new virus that is now circulating. "Flu is unpredictable, but what we've seen thus far is concerning," says Dr. Thomas R. Frieden. According to the CDC, five U.S. children have died from flu-related complications so far this season. Four of them were infected with influenza A viruses, including three cases of H3N2 infections. The new H3 subtype first appeared overseas in March but because it was not found in many samples in the United States until September, it is now too late to change the vaccine. Because of the increased danger from the H3 strain — and because B influenza strains can also cause serious illness — the CDC recommends that patients with asthma, diabetes or lung or heart problems see a doctor at the first sign of a possible flu, and that doctors quickly prescribe antivirals like Tamiflu or Relenza. "H3N2 viruses tend to be associated with more severe seasons," says Frieden. "The rate of hospitalization and death can be twice as high or more in flu seasons when H3 doesn't predominate."
163 comments | about two weeks ago
Bennett Haselton writes: Twitter has announced new protocols for filing and handling abuse reports, making it easier to flag specific types of content (e.g. violence or suicide threats). But with the volume of abusive tweets being reported to the company every day, the internal review process will always be a bottleneck. The company could handle more abuse reports properly by recruiting public volunteers. Read what Bennett thinks below.
132 comments | about two weeks ago
mikejuk writes It seems incredible that in the 21st century schools are still teaching children to scratch marks on paper. Well in Finland they are taking a step in the direction of the future by giving up teaching handwriting. The Savon Sanomat newspaper reports that from autumn 2016 cursive handwriting will no longer be a compulsory part of the school curriculum. Instead the schools will teach keyboard skills and 'texting'. The idea of teaching proper keyboard skills to children is unquestionably a great idea, the idea of texting is a little more dubious and many will mourn the loss of a traditional skill like cursive writing. So what about a world where cursive writing is forgotten? What do you do when your computer is dead and you need to leave a note? The death of cursive script probably isn't the death of handwriting but the death of doing it quickly and with style. Some no doubt will want to master it just for the sake of it — like driving a stick shift. I know some U.S. schools have done the same; how proficient should kids be with cursive?
523 comments | about three weeks ago
HughPickens.com writes Jason Kane reports at PBS that emergency treatments delivered in ambulances that offer "Advanced Life Support" for cardiac arrest may be linked to more death, comas and brain damage than those providing "Basic Life Support." "They're taking a lot of time in the field to perform interventions that don't seem to be as effective in that environment," says Prachi Sanghavi. "Of course, these are treatments we know are good in the emergency room, but they've been pushed into the field without really being tested and the field is a much different environment." The study suggests that high-tech equipment and sophisticated treatment techniques may distract from what's most important during cardiac arrest — transporting a critically ill patient to the hospital quickly.
Basic Life Support (BLS) ambulances stick to simpler techniques, like chest compressions, basic defibrillation and hand-pumped ventilation bags to assist with breathing with more emphasis placed on getting the patient to the hospital as soon as possible. Survival rates for out-of-hospital cardiac arrest patients are extremely low regardless of the ambulance type with roughly 90 percent of the 380,000 patients who experience cardiac arrest outside of a hospital each year not surviving to hospital discharge. But researchers found that 90 days after hospitalization, patients treated in BLS ambulances were 50 percent more likely to survive than their counterparts treated with ALS. Not everyone is convinced of the conclusions. "They've done as much as they possibly can with the existing data but I'm not sure that I'm convinced they have solved all of the selection biases," says Judith R. Lave. "I would say that it should be taken as more of an indication that there may be some very significant problems here."
112 comments | about three weeks ago
An anonymous reader writes: A grand jury in Missouri has decided there is no probable cause to charge police officer Darren Wilson in the shooting death of Michael Brown. "A grand jury of nine whites and three blacks had been meeting weekly since Aug. 20 to consider evidence. At least nine votes would have been required to indict Wilson. The Justice Department is conducting an investigation into possible civil rights violations that could result in federal charges." Government officials and Brown's family are urging calm in Ferguson after the contentious protests that followed Brown's death.
1128 comments | about three weeks ago
HughPickens.com writes Josh Planos writes at The Atlantic that the isolated village of Hogewey on the outskirts of Amsterdam has been dubbed "Dementia Village" because it is home to residents who are only admitted if they're categorized as having severe cases of dementia or Alzheimer's disease. "There are no wards, long hallways, or corridors at the facility," writes Planos. "Residents live in groups of six or seven to a house, with one or two caretakers. Perhaps the most unique element of the facility—apart from the stealthy "gardener" caretakers—is its approach toward housing. Hogeway features 23 uniquely stylized homes, furnished around the time period when residents' short-term memories stopped properly functioning. There are homes resembling the 1950s, 1970s, and 2000s, accurate down to the tablecloths, because it helps residents feel as if they're home."
In Holland, everyone pays into the state health care system during their working years, with the money then disbursed to pay for later-in-life expenses — and that means living in Hogewey does not cost any more than a traditional nursing home. The inspiration came about in 1992, when Yvonne van Amerongen and another member of staff at a traditional nursing home both had their own mothers die, being glad that their elderly parents had died quickly and had not had to endure hospital-like care. A series of research and brainstorming sessions in 1993 found that humans choose to surround and interact with other like-minded people of similar backgrounds and experiences; the arrangement at Hogewey provides this by ensuring that residents with similar backgrounds continue to live closely together. On a physical level, residents at Hogewey require fewer medications; they eat better and they live longer. On a mental level, they also seem to have more joy. "The people here keep their independence, as much as they can have of it, and they stay active," says Theo Visser. "Here they still have a life. It's not the sort of slow, quiet death you get in other places. Here everyone feels at home."
231 comments | about a month ago
Recently you had a chance to ask acclaimed author of comics, novels, and television, Warren Ellis, about his work and sci-fi in general. Below you'll find his answers to your questions.
15 comments | about a month ago
schwit1 writes Glen A. Larson, the wildly successful television writer-producer whose enviable track record includes 'Six Million Dollar Man', Quincy M.E., Magnum, P.I., Battlestar Galactica, Knight Rider and The Fall Guy, has died. He was 77. From the article: Battlestar Galactica lasted just one season on ABC from 1978-79, yet the show had an astronomical impact. Starring Lorne Greene and Richard Hatch as leaders of a homeless fleet wandering through space, featuring special effects supervised by Star Wars’ John Dykstra and influenced by Larson’s Mormon beliefs, Battlestar premiered as a top 10 show and finished the year in the top 25. But it was axed after 24 episodes because, Larson said, each episode cost “well over” $1 million.
186 comments | about a month ago
HughPickens.com (3830033) writes David Wagner writes that a predictive computer model using machine learning methods is helping to identify soldiers in the United States Army most likely to commit suicide. Computers combed through data on more than 40,000 soldiers who'd been hospitalized for mental health problems looking at 421 variables on each soldier drawn from 38 military data systems. Using a method known as "machine learning," the researchers identified roughly two dozen factors that are most important in predicting soldiers most likely to commit suicide. The soldiers most likely to take their own lives were men with past suicidal behavior and a history of psychiatric disorders and criminal offenses, including weapons possession and verbal assaults. Soldiers with hearing loss also faced heightened risk — a strong indicator that they had suffered a head injury. So did enlisting in the Army after age 27, most likely because those soldiers had already experienced trouble finding their way in life. "There's this group that comes to the Army later in life — they're smart, they have skills, they tend not to be married and they have no career or have left a career to join," Dr. Kessler said. "We don't know why they should be at higher risk, but they appear to be."
Murray Stein, co-author of the new study, found that among soldiers recently discharged from psychiatric hospitals, more than half of suicides were committed by just five percent of patients. "The most impressive thing is that they identified this high-risk group in the hospital, and by just focusing on one in 20 of them, you're really dramatically improving your ability to predict," says Dr. Mark Olfson, a professor of psychiatry at Columbia University who was not involved in the study. "Clinicians don't do a very good job predicting suicide risk, even though we think we do."
74 comments | about a month ago
Dave Knott writes Raymond Almiran Montgomery, original publisher and author of the incredibly popular "Choose Your Own Adventure" book series for children, the 4th bestselling children's series of all time, has died at the age of 78. In 1975, Montgomery founded a small press and when, in 1977, Ed Packard submitted an innovative book for young readers, "Sugarcane Island", Montgomery immediately saw it for what it was: a role-playing game in book form. He leapt at the chance to publish it, and launched a series, writing the second book, "Journey Under The Sea", himself. When Montgomery went through a divorce and sold his stake in the press to his ex-wife, he took the series, renamed as "Choose Your Own Adventure", to Bantam. The books went on to sell more than 250 million copies across 230 titles in 40 languages. Montgomery's interests also extended to new technology, adapting the series to the Atari console in 1984. He was also responsible for the Comic Creator software on Apple's Macintosh computers. Montgomery died on November 9th. The cause of death was not disclosed.
80 comments | about a month ago
An anonymous reader writes Alexander Grothendieck, one of the great eccentric geniuses of 20th century mathematics, has died in France at the age of 86. Grothendieck was the leading mind behind algebraic geometry. He was awarded the Fields Medal in 1966. He reached the very pinnacle of his profession before abandoning the discipline, taking up anti-war activism, retreating into the life of a recluse and refusing to share his research. He died on Thursday in a hospital in Saint-Girons in southwestern France.
49 comments | about a month ago
HughPickens.com writes "Patrick McGeehan writes in the NYT that the image of a pair of window washers clinging to a scaffold dangling outside the 68th floor of 1 World Trade Center have left many wondering why robots can't rub soapy water on glass and wipe it off with a squeegee relieving humans of the risk of injury, or death, from a plunge to the sidewalk? The simple answer, several experts say, is that washing windows is something that machines still cannot do as well as people can. "Building are starting to look like huge sculptures in the sky," says Craig Caulkins. "A robot can't maneuver to get around those curves to get into the facets of the building." According to Caulkins robotic cleaning systems tend to leave dirt in the corners of the glass walls that are designed to provide panoramic views from high floors. "If you are a fastidious owner wanting clean, clean windows so you can take advantage of that very expensive view that you bought, the last thing you want to see is that gray area around the rim of the window."
Another reason for the sparse use of robots is that buildings require a lot more maintenance than just window cleaning. Equipment is needed to lower people to repair facades and broken windows, like the one that rescue workers had to cut through with diamond cutters to rescue the window washers. For many years, being a window cleaner in Manhattan was regarded as one of the most dangerous occupations in the world: by 1932, an average of one in every two hundred window cleaners in New York was killed each year. Now all new union window cleaners now take two hundred and sixteen hours of classroom instruction, three thousand hours of accredited time with an employer and their union makes sure workers follow rigorous safety protocols. In all, there are about 700 scaffolds for window washing on buildings in New York City, says union representative Gerard McEneaney. His members are willing to do the work because it pays well: as much $26.89 an hour plus benefits. Many of the window cleaners are immigrants from South America. "They're fearless guys, fearless workers."
203 comments | about a month ago
TaleSlinger (3080869) writes Scientists following two different lines of evidence have just published research [Here's the abstract to the paywalled Science paper] that may help resolve "Darwin's dilemma," a mystery that plagued the father of evolution until his death more than a century ago. Life appeared when the earth was tens of millions of years old, but evolution didn't go into high gear until the "Cambrian Explosion", nearly a billion years later. The two papers propose complementary theories that help explain this. The first suggests that scientists have long overestimated the amount of oxygen in the earth's atmosphere in the pre-Cambrian era just before the "explosion." The second suggests suggests that very dramatic changes driven by the tectonic breakup of the so-called "supercontinents" of the pre-Cambrian era could have caused an extraordinary leap in oxygen levels of both the ancient oceans and the earth's atmosphere. These two studies fit neatly together, suggesting that a world deprived of oxygen could have changed relatively quickly into an incubator for new life in shallow ponds spread across the continents and fed by waters rich in nutrients. Perhaps that set the stage for the explosion, which may have been five times the evolutionary rate seen today.
78 comments | about a month ago