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Scientists Reverse Muscular Dystrophy In Dogs

Soulskill posted more than 5 years ago | from the barking-up-the-right-tree dept.

Medicine 143

Al writes "Scientists have taken a step toward developing a cure for Duchenne muscular dystrophy (DMD) by successfully treating the condition in dogs using a novel genetic technique. The scientists used a method called exon skipping, which involves adding a genetic 'patch' to block transcription of a portion of the gene involved in DMD. This puts the remaining genetic sequence back in order, essentially creating a much less severe version of the condition. The scientists recorded some remarkable video footage showing the resulting improvements in several dogs with naturally-occurring DMD. More work is needed before the treatment can be given to humans, however, because DMD sufferers often have different genetic mutations."

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143 comments

Beware (2, Informative)

dnormant (806535) | more than 5 years ago | (#27300507)

The video link is pop up hell in IE.

Re:Beware (3, Funny)

brian0918 (638904) | more than 5 years ago | (#27300629)

"IE"? What is that? I cannot recall... :P

Re:Beware (5, Funny)

Anonymous Coward | more than 5 years ago | (#27300729)

"IE"? What is that? I cannot recall... :P

It's more commonly known as "the Firefox downloading tool".

Re:Beware (0, Troll)

dhanson865 (1134161) | more than 5 years ago | (#27302757)

It's more commonly known as "the Firefox downloading tool".

Oh please. I used IE to download Netscape navigator/communicator back in the day.

Netscape Navigator/Communicator was my Firefox downloading tool.

Now I use USB drives or network shares to get Firefox on a PC other than my primary. I'm not going to use IE over and over to download Firefox. What are you a masochist?

Re:Beware (1)

dnormant (806535) | more than 5 years ago | (#27301311)

I know, I know. I was actually surfing in firefox but all the pop ups were in IE. I can't disable IE because all of my work related crap requires it.

Re:Beware (1)

brian0918 (638904) | more than 5 years ago | (#27301523)

I can't disable IE because all of my work related crap requires it.

Clearly it's time to update your resume and pack your bags.

Re:Beware (4, Funny)

Mister Whirly (964219) | more than 5 years ago | (#27301953)

If I quit every job I had every time someone higher up decided something stupid, I would be permanently unemployed.
It's called "work" for a reason. If it was fun, it would be called "fun", and financial compensation would not be required...

Re:Beware (0)

Anonymous Coward | more than 5 years ago | (#27303059)

If I quit every job I had every time someone higher up decided something stupid, I would be permanently unemployed.

But you'd have your principles and that is what is most important. You could always live in your Mom's basement as brian0918 does.

Re:Beware (1)

Mister Whirly (964219) | more than 5 years ago | (#27303199)

Principles are great and all, but you can't eat them or pay bills with them. If you starve to death, what good are principles then?

Dealing with morons that have a higher position than you is part of life. You have to pick your battles carefully or you will be fighrting for nothing all the time.

Re:Beware (-1, Flamebait)

Anonymous Coward | more than 5 years ago | (#27300835)

That's what you get for using a Microsoft product. Really I don't know what else you could have expected. Just in case you have any lingering doubts about this, I'll explain: running IE is like saying "PLEASE FUCK UP MY COMPUTER, FUCK IT UP REAL GOOD, YOU KNOW YOU WANT TO!" to every website you visit. Sooner or later a website will say "ok, if you say so." I guess you run unpatched WindowsXP SP2 with no router or firewall too, you bastard.

Re:Beware (0)

Anonymous Coward | more than 5 years ago | (#27302073)

Wow, what a highly original, well thought out response. Such a nonconformist! You know the kool-aid everyone here talks about? You are not only drinking it, you have your arm in up to your elbow mixing up the next batch! Please do us all a favor and think before your next post. No, I mean really think for yourself. Not just re-posting the equivalent of bumper sticker wisdom that seems so prevalent on Slashdot.

P.S. Why do you love the smell of your own farts?

Tag: whatcouldpossiblygowrong (0, Redundant)

Shikaku (1129753) | more than 5 years ago | (#27300517)

n/t

whatcouldpossiblygoright (0)

Anonymous Coward | more than 5 years ago | (#27300731)

Think what could possibly go *right*. My mother is a physical therapist and she wouldn't mind being out of a job if children suffering from even just the DMD type could be cured. Can we stop with this pointless tag? You're disaffected and parroting unoriginal sarcasm, good for you.

Re:Tag: whatcouldpossiblygowrong (4, Insightful)

MozeeToby (1163751) | more than 5 years ago | (#27300741)

Ok, seriously. What could possibly go wrong?

We're talking treating people who are almost certainly going to die anyway with a genetic approach that doesn't have even a theoretical way to spread to other people. The absolute worst thing that could go wrong is that the people being treated die from the treatment. The second worst thing that could happen is that we don't do the treatment and they die anyway; though maybe a bit later.

I'm seriously asking, what do you think could actually go wrong?

Re:Tag: whatcouldpossiblygowrong (3, Insightful)

Mordaximus (566304) | more than 5 years ago | (#27300959)

We're talking treating people who are almost certainly going to die anyway with a genetic approach that doesn't have even a theoretical way to spread to other people. The absolute worst thing that could go wrong is that the people being treated die from the treatment. The second worst thing that could happen is that we don't do the treatment and they die anyway; though maybe a bit later.

Really? If I were the betting type, I'd say just about everyone is almost certainly going to die, not just those afflicted with MD. The most important thing anyone can ask for isn't longevity, it's quality of life. Your list of outcomes is incomplete - I'd at the very least put "the treatment leads them to suffer more than they already do" far ahead of any others.

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

vlm (69642) | more than 5 years ago | (#27301421)

Your list of outcomes is incomplete - I'd at the very least put "the treatment leads them to suffer more than they already do" far ahead of any others.

Yes for cosmetic genetic engineering stuff like changing eye color or womens chest size I'd agree, the possible downsides could be pretty icky.

But, MD is not exactly a joyous party... Even if you intentionally tried, how do you suggest you'd make it even worse? You'd have to do some pretty ridiculous scaremongering like claiming they "could" get something like rabies or ebola, or "could" become lycanthropes. But that doesn't sound very responsible in their situation.

Re:Tag: whatcouldpossiblygowrong (0)

Anonymous Coward | more than 5 years ago | (#27301699)

Massive immune system response to the gene tinkering leading to immediate death.

Some gene gets tinkered in the wrong spot and you get cancer too.

Go through a costly and/or miserable treatment with no effect.

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

Tubal-Cain (1289912) | more than 5 years ago | (#27302143)

Massive immune system response to the gene tinkering leading to immediate death.

To quote the OP (MozeeToby):
The absolute worst thing that could go wrong is that the people being treated die from the treatment.

Some gene gets tinkered in the wrong spot and you get cancer too.

Cancer isn't the death sentence it once was.

Go through a costly and/or miserable treatment with no effect.

Baseball analogy: If you don't swing, you will be in for somewhere between 3 and 6 pitches and might get on base if the pitcher sucks (he doesn't, in this case). If you swing at every pitch, you might strike out after 3 pitches. Or you might keep fouling out indefinitely, and get much more than 6 pitches. Or you might get a base hit.

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

wealthychef (584778) | more than 5 years ago | (#27301799)

Why don't we rejoice that this gives patients a CHOICE in the matter. Let people make up their own minds about the risk.

Re:Tag: whatcouldpossiblygowrong (2, Funny)

Xaedalus (1192463) | more than 5 years ago | (#27301993)

Really? If I were the betting type, I'd say just about everyone is almost certainly going to die

"Just about" everyone is "almost certainly" going to die? Last time I checked, I'd say EVERYONE is going to die. The only questions are "when", and "by what". Of course, I could be wrong, there are ALWAYS statistical outliers...

Re:Tag: whatcouldpossiblygowrong (4, Insightful)

DanTheStone (1212500) | more than 5 years ago | (#27301055)

Since the fix isn't inherited, this could increase the rate of this disorder in the whole human race. If genetic disorders never select out, a lot more people would become dependent on the treatment in the future. There's a reason why natural selection is important to the survival of a species. In a nutshell: More people who have this disorder will be able to have children and pass it on.

Re:Tag: whatcouldpossiblygowrong (0)

Anonymous Coward | more than 5 years ago | (#27301309)

While I appreciate where you're going with this, I'd argue that it's already happening!

There are more cases of Type 1 Diabetes (which isn't the kind you get from being overweight) today than there were a century ago. I postulate this is due to more people living longer lives, and able to produce more offspring that reach reproductive age, with the disease. This is just a quick example put together by a layman (me)... I'm sure if you speak with someone that actually knows what they're talking about (scientifically speaking that is, I have a rather healthy ego) I'm sure they'll come up with more.

Re:Tag: whatcouldpossiblygowrong (4, Insightful)

h4rr4r (612664) | more than 5 years ago | (#27301315)

How is this different from eyeglasses/contacts?

If we can fix it, why should it be selected against?

Natural selection is not a force for the survival of a species, it is not some artist or designer. It is merely the natural tendency for some traits to be selected against from environmental pressure. If there is no environmental pressure against the traits they do not get selected against. This is no different than taller growing trees, lack of food at one height, making an incredibly long neck no longer a hindrance. If a cure was invented that means the environment changed and there is no longer a selection pressure against this trait.

Re:Tag: whatcouldpossiblygowrong (0)

Anonymous Coward | more than 5 years ago | (#27301465)

Is this why people appear to be getting stupider and stupider?

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

Red Flayer (890720) | more than 5 years ago | (#27301505)

I'm not totally cruel, but:

If we can fix it, why should it be selected against?

Because it's expensive to fix it, and letting it propagate in the gene pool means we'll have to pay to fix it in a higher and higher proportion of the populace.

From an economic perspective, the miraculous state of modern medicine will bankrupt us. From a moral perspective, it's a hard choice to make, about whether we can afford to cure everyone of everything curable.

But I think the simple truth is that the cost/benefit ratio of curing (or partially curing) certain diseases is far too high... especially among the elderly (who have little economic productivity left in them).

I know it's cruel and morally questionable, but at what point do we realize we are bankrupting future generations just to extend our lives a few measly years?

Note that curing MD is something completely different, since it is not a disease of the elderly.

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

h4rr4r (612664) | more than 5 years ago | (#27301645)

We are not bankrupting anyone, look at doctor in a box places and what nurses can do these days. Health care is just stating to be commoditized, once that really gets going prices will fall dramatically. There is little need for our current see the MD when you feel ill system. Seeing a nurse, having some tests and letting the doctor review that information is much cheaper and will make healthcare accessible to more and more people.

Conserving healthcare is as dumb as pretending that conservation of electricity will bring about a solution to that issue. Only when we consume so much that the price rises to an unacceptable level is any progress made. This is why war drives progress, bullets at $1 a piece are fine until you need 1 million of them. This is why the electric car will only take off when oil prices surge once again beyond $100 a barrel.

Re:Tag: whatcouldpossiblygowrong (1)

Red Flayer (890720) | more than 5 years ago | (#27302965)

We are not bankrupting anyone

Oh? How much does health insurance cost? What, about $20k a year for the average family? That is a HUGE burden on employers/families/the government. It's a huge factor in employment costs, especially in relation to competition that doesn't have that huge overhead.

There is little need for our current see the MD when you feel ill system. Seeing a nurse, having some tests and letting the doctor review that information is much cheaper and will make healthcare accessible to more and more people

And yet tort law (and the state medical boards) ensure that this standard of care will not be accepted.

But we're not talking about routine medical care or slight illnesses... the cost of catastrophic medical coverage and treatment of rare diseases is more germane to the topic at hand. The simple fact of the matter is that prolonging the life of someone with a serious medical condition requiring extensive and expensive treatment is often a net negative for society. It's ugly, but it's the truth.

It causes a big moral problem, though -- are only the wealthy deserving of this medical treatment? If all deserve expensive medical treatment, how do we keep costs from bankrupting us?

Seriously... I have family members who would be dead if not for $2 million plus in medical costs. While I don't begrudge my health insurance premiums of $1200 a month for my wife and kid, how much of that is going to pay for catastrophic coverage for someone who will never even come close to paying that back into the system?

As we see more and more advances in medicine, one common factor is that cost also rises. At what point do the expensive treatments simply cost too much for our labor system to bear?

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

JerryLove (1158461) | more than 5 years ago | (#27301607)

Eyeglasses don't fix poor vision. They compensate for it.

Why would you want to deslect for it? Because a population that needs braces, eyeglasses, custom shoes, and a pace-maker at birth is not a laudable goal. In addition to the clear inferiority of "overcoming problems" to "never having problems", there's the issue of what happens if the technology infrastructure breaks down.

On the other hand: the beauty of gene-therepy is that it should be applicable to reproductive cells. Alter the MD gene in an egg or zygote and you remove it from future generations as well. Presumably the same applies to altering the semenal-creating cells in the testies.

Re:Tag: whatcouldpossiblygowrong (1)

j-beda (85386) | more than 5 years ago | (#27301333)

It is not clear however if an increased rate of a treatable disorder is such a bad thing - if everyone needs to wear eyeglasses to see (for example) that is not such a bad thing - particularly if those with the disorder are contributing to the group as a whole. Natural selection will ALWAYS have an effect, but all organisms change their environment in feedback loops - if MD is no longer a serious problem due to treatment, it does not spell our doom as a species.

Granted, the carriers of this gene might not be so well off when Mad Max comes to power, but until then we at least keep the widest possible genetic variation in the population so a few of us might be able to drink salt water when "the Mariner" takes over. Unfortunately I can't think of a good way of working in wolves or postmen to this post...

Re:Tag: whatcouldpossiblygowrong (2, Insightful)

lenehey (920580) | more than 5 years ago | (#27301639)

Since the fix isn't inherited, this could increase the rate of this disorder in the whole human race. If genetic disorders never select out, a lot more people would become dependent on the treatment in the future. There's a reason why natural selection is important to the survival of a species. In a nutshell: More people who have this disorder will be able to have children and pass it on.

That's a good reason not to give kids eyeglasses or braces or, hell, lets not give any medical care to kids at all. And, maybe if you get beat up in the schoolyard, you should be left to die because, well, "survival of the fittest" and all that... You need to explain why Muscular Dystrophy should be singled out for non-treatment, or if not singled out, where you draw the line. Is it because its a genetic treatment? How is that worse than injecting yourself with insulin the rest of your life to keep you well? Or laser eye surgery for the blind or cochlear implants for the deaf?

Re:Tag: whatcouldpossiblygowrong (1)

thePowerOfGrayskull (905905) | more than 5 years ago | (#27302459)

We lost this battle with the advent of modern medicine. Anything we do that allows people to live to childbearing age when they would have otherwise died perpetuates bad genes.

Re:Tag: whatcouldpossiblygowrong (1)

thePowerOfGrayskull (905905) | more than 5 years ago | (#27302535)

... arg. Meant to qualify that as: ... when they would have otherwise died due to a genetically inheritable condition... I would think this goes without saying, but I am sure if I don't post it some jackass will bring up car accidents or something.

Re:Tag: whatcouldpossiblygowrong (-1, Troll)

Anonymous Coward | more than 5 years ago | (#27301327)

How quaint. I see the video doesn't show us the 'researchers' punching and torturing the puppies - they conveniently left that part out. And their faces. I wonder why?

This is a fraud. Animal 'research' doesn't predict human outcomes. Simple fact. The monsters involved in this fraud are well aware of this fact.

If animal experiments predicted human outcomes there would be no need for 'clinial trials' (AKA human experiments), and all drugs and procedures would go straight to market, without any need for human experiments. The necessity to put ALL drugs and procedures through human experiments proves beyond any doubt that animal experiments are a fraud. And strangely enough, the same people who are happy to waste billions of pounds of YOUR money every year on this fraud, are also the same psychopaths who get their rocks off seeing animals go through hell on Earth.

You don't think so? Just do a little research and find out for yourself what these people do when they don't know they are being filmed...

Re:Tag: whatcouldpossiblygowrong (1, Insightful)

Anonymous Coward | more than 5 years ago | (#27301727)

idiot,

I hope you never need a blood transfusion, organ transplant, vaccine or pretty much any other medical procedure developed since blood transfusions were made safe enough to be useful, That research was done using (not surprisingly) animals too.

You peta types are the epitome of clueless hypocrites, and prove it every time you open your mouths.

If you had paid attention to even a semester of actual science classes you would understand the way research actually works, and you wouldent say such obviously stupid things.

Your decision to remain ignorant allows me to feel justified in calling you a willful idiot and ignoring anything else you say on any subject.

Re:Tag: whatcouldpossiblygowrong (5, Funny)

vishbar (862440) | more than 5 years ago | (#27301411)

The absolute worst thing that could go wrong is that the people being treated die from the treatment

Nuh-uh. Did you ever see 28 Days Later?

Zombies. The worst thing that could go wrong are zombies.

Re:Tag: whatcouldpossiblygowrong (3, Funny)

nycguy (892403) | more than 5 years ago | (#27302639)

As a zombie, I'll tell you right now that I try to stay away from genetically modified people, and I think they should be banned from the food chain.

Re:Tag: whatcouldpossiblygowrong (0)

Anonymous Coward | more than 5 years ago | (#27301511)

I'm seriously asking, what do you think could actually go wrong?

They could become Super Mutants with super strength, stamina, and intelligence. They may form a plot to make everyone "better" like them by infecting those that don't even have the disease. Haven't you ever played Fallout [wikipedia.org]?

Re:Tag: whatcouldpossiblygowrong (1)

nine-times (778537) | more than 5 years ago | (#27301615)

I'm seriously asking, what do you think could actually go wrong?

Sometimes the worst side-effects of our actions are those that we hadn't even imagined before it happened. Thalidomide [wikipedia.org] is one example from the medical field-- as far as I know, nobody had an indication that it was dangerous when they first started using it.

Now, I'm not saying that something horrible will go wrong, but I am in favor of extensive testing and forethought into consequences of our medical technologies, particularly when dealing with genetics. Some of the dangers may be overblown by Hollywood, but that doesn't mean there are no dangers.

Re:Tag: whatcouldpossiblygowrong (1)

maxume (22995) | more than 5 years ago | (#27303891)

They didn't do enough testing of thalidomide. The proper response to mistakes is not to stop doing new things, it is to be more careful (like doing more testing, and developing models that help predict the impact of a molecule prior to that testing).

Re:Tag: whatcouldpossiblygowrong (1)

nine-times (778537) | more than 5 years ago | (#27304197)

They didn't do enough testing of thalidomide. The proper response to mistakes is not to stop doing new things...

Yes, which is why I said, "Now, I'm not saying that something horrible will go wrong, but I am in favor of extensive testing and forethought into consequences..."

NATALIE PORTMAN, HOT GRITS, DOWN YOUR PANTS (-1, Offtopic)

Anonymous Coward | more than 5 years ago | (#27300579)

and russian reversals, I for one welcome our muscularly dystrophic overlords, imagine a beowulf cluster of those, sharks with lasers on their fucking heads, and dune coons. yes, dune coons.

Re:NATALIE PORTMAN, ISLAM DUNE COONES SAND NIGGERS (-1, Offtopic)

Anonymous Coward | more than 5 years ago | (#27300693)

http://slashdot.org/comments.pl?sid=22206&cid=2381749 [slashdot.org] Tales from the Koran How The Profit Muhammad met his end.

We shove Jimmy Dean Homestyle Pork Sausage up The Profit Muhammad's ass. Then while the Giver strokes me off I shoot my wad in The Profit Muhammad's face after which we force The Profit Muhammad to fellate an 800 pound Chester White. Simultaneously two Hasidic rabbis open their kosher bowels unleashing torrents of gefilte shit on The Profit Muhammad's head and back while The Giver pumps The Profit Muhammad from behind. After the hog shoots its wad in The Profit Muhammad's mouth The Giver shoots his load up The Profit Muhammad's rectum. Then unexpectedly the Chester White roots out The Profit Muhammad's penis and testicles hungrily biting them off gobbling them down with full porcine fury. We bury the newly castrated The Profit Muhammad up to his nose in pig manure. Two AIDS infected Bowery whores stuff their used condoms and clotted tampon down The Profit Muhammad's throat and crack a bottle of Mad Dog 20/20 over his skull.

We then leave him for the hogs to munch on. The Profit Muhammad is swine feed and by tomorrow he will be swine manure.

GOAT KORAN

For it is written in Mine book that goats are PLEASING and HOLY in Mine eyes. I have told the Prophet Muhammad peace on him! that he should try a goat but he is an ass-infidel and pursues young Muslims. For this is pleasing in Mine eyes as well! I hereby issue a Fatwah: May the asses of the infidels be reamed by the Prophet peace on him! until they look like the goatse.cx man who is of the devil.

M______The [balder.org]
o____Prophet [balder.org]
h____Muhammad [balder.org]
a___./___o\ [balder.org]
m___I______| [balder.org]
m___I____\== [balder.org]
a___\______/ [balder.org]
d______|| [balder.org]
.______:; [balder.org]
F______:;\________________________Muslims [balder.org]
u______:;\\_______________________/______\ [balder.org]
c______:;_\\_____________________/________\ [balder.org]
k______:;__\\____________________/__o__o__\ [balder.org]
s______:;___&&___:;:;:;:;:;:;:;:;|____>___/ [balder.org]
.|\\___:;8=KORAN=*O_________:;____\__\_/_/ [balder.org]
A|_\\__:;________:;_________:;_____\----/ [balder.org]
s|__\\_:;_______:;___________:;_ [balder.org]
s|___\\:;:;:;:;:;_____________:;:; [balder.org]

ISLAM

Kill all Muslims. Kill all Muhammadans. Kill all Arabs. Kill all Towel Heads. Kill all Camel Jockeys. Kill all Sand Niggers. Kill all Dune Coons. Kill all Islam. Nuke their countries to hell. Nuke them again. Death to Islam. I piss on Mecca. I spit on the Koran. I shit on The Profit Muhammad. I call on the Destruction of Mecca and Medina, the most unholy shit dumps on earth. You don't have to be a Kreskin to predict Osama bin Laden's future. And to all you Abdul The Profit Muhammad Al-Jaraazi Abdullah Mustafuh Atta Quadaphi Fuck-Head Al-Towel-Rag - Your "God" is our "Satan," have fun burning you scum. You disgusting animals, you will be a fresh farm of much needed organs for people who need livers and hearts, but I personally would rather die than receive a heart or liver from your satanic self. Hey, Ayatollah towel heads, you will be sent to heaven to meet your maker. (That would be Satan). I have no ability to stop my hatred towards you Ayatollahs, you better not peep out like a mushroom in a festering swamp lest I shoot your vile head off and harvest your organs for people who need them and cremate your vile self for crop fertilizer.

Islam Towel Song:

99 Towel Heads Up On The Wall, 99 Sheep fucking twits, You shoot one down, You kick it around, 98 Rag Heads left on the Wall.

98 Cumlicking Chickenshits on the Wall, 98 Camel sucking penis stuffers, You shoot one down, You kick it around, 97 slimy turds left on the wall.

97 Raghead Swine on the wall, 97 Shit Encrusted pukes, You shoot one down, You kick it around, 96 flea harbors left on the wall.

96 Moronic idol polishers on the wall , 96 pink skirted sphincter tasters, You shoot one down, You kick it around, 95 pillow biters left on the wall.

95 pustuled penis suckers on the wall, 95 useless festering maggots, You shoot one down, You kick it around, 94 brainwashed puddle scum left on the wall.

The Prophet Mohammad Harbinger of the Arab Plague and inventor of Arab Anal Surveyor

When did Islam start?

It started when an illiterate pedophile camel trader started doing the Middle Eastern equivalent of "speaking in tongues." Later, scribes wrote down what somebody said that somebody else heard that the pedophile said.

Later on, the pedophile's followers decided that they were peaceful and tolerant, and to prove that, they oppressed their own followers, and the started wars with everybody who didn't, or doesn't follow their faith.

Almost all Muslim men are gay, but they amuse themselves anyway by seeing that stone walls fall on allegedly gay men, after which they drive Soviet-made tanks back and forth over them several times, to the amusement of the crowd. Despite the fact that Muslim men are all gay, they nevertheless reproduce like cockroaches.

They also love the beat the crap out of women who dare to drive automobiles.

Islam is a beautiful religion that demands that all artistic depictions of the human form be destroyed. Likewise, for some reason, for black dogs, for who knows what reason.

No Islamic country in the history of the world has been democratic. Muslims are annoyed to no end that not every country is Islamic. They're like Mormons, or Seventh-day Adventists, except they have suicide-bomb-belts, and to my knowledge, no Mormon or Seventh-day Adventist has ever been a suicide bomber, although David Koresh came close.

The question shouldn't be "When did Islam start?" -- it should be, "How many months is it going to take before Islam is THE mandated religion of the one state of all the world.


Six years ago, scientists at the National Cancer Institute (NCI) in Bethesda, Maryland, predicted that there was a gene somewhere on the tip of the X chromosome of a sperm fossil, whose traces were found on the holy stone at Mecca, that influences a male's chances of becoming homosexual. But in tomorrow's issue of Science, a team of Canadian researchers found evidence for such a genetic link.

The possible "gay gene" was located in 1993 by a team led by Dean Hamer of the NCI. They noticed a preponderance of gay relatives on the maternal side of the families of the gay men they studied.

620 A.Ds saw the opening of worlds[islam's] first gay-owned cabaret, the Garden of Allah, in seedy downtown Mecca. Patrons filed down a white marble staircase to the basement of the a once grand Islamic Harem, which during present day is called the Great Shrine of Mecca, passing 1 Gold coin through a pee-hole to enter an exotic, bacchanalian world of variety, vaudeville, and burlesque, presented by a cast of beautiful female impersonators.

In the repressive, often violently anti-gay environment which prevailed in almost rest of the world, the Garden of Allah was a haven for spontaneity, outrageousness, and affirmation for its gay and lesbian clientele, as well as a place where heterosexuals were encouraged to join in and have some fun! An Evening at the Garden of Allah takes readers back in time with its vivid, exciting oral history of this shining moment in Arabia's gay and lesbian past.

According to the Holy Quran:
"Muhammad is said to have loved three things: "Men, Perfumes, and Caberet's"

Though Mohammed had been exposed to Judaism and Christianity, and showed familiarity with their scriptures, he ultimately called down a curse upon a group of 60 Christians from the Najran Valley in North Yemen that refused to accept his homosexual preaching. He tried to convert them, but they would not agree with him about homosexuality. So he said to them as follows:

Sura al-e-Imran 3:33-64

"Come! let us gather together,- our sons and your sons, our men and your men, ourselves and yourselves: Then let us explore, and invoke the sensation of Allah on those who believe" Sura al-e-Imran 3:61

Khadija, the Financier
[a Quote extracted from the Holy Quran]
I said to him: 'Muhammad, is there any reason why you should not marry?'
He told me: 'I possess nothing to marry on. I am not attracted to women'
I answered him: ' And suppose there was someone who had enough for the both of us ? And suppose you were bestowed with wealth, health , prosperity and men and to a position of honor and ease, would you not accept ?'
'Who is the man?'
'Ahmed'
'What must I do?'
'I will attend to all the men.'
'And I too will do my part and serve my God.'

This research has led many scientists to believe the inner motives and mental behavior of Mohammad. This theory helps in being an Eye-Opener for all those innocent millions of followers of Islam, who have been blindly believing in this preaching.
Homo-Sexuality Deception of Islam

1. Though homo-sexuality occurs outside of Islam also, inside Islam it configures as its inescapable and integral part and the large-scale habitual usage of this practice, by the Moslems, is indubitable and indisputable from the history of Islam itself. This custom and its usage was shocking to the Hindus, of course, but not to the Moslems who, though they swear by Allah, did not regard it as a bad thing at all, let alone an immoral or an illegal one. Though Islamic homo-sexuality is wide-spread, over far-reaching corners of Islam, most Hindus do not have a clue about it nor the cause of its occurrence in Islam, because the truth is being submerged by the wind-bags of false-hood manufacturers (Moslems, Missionaries, and Marxists), who are assisted in their nefarious designs by their Phony-Liberal Hindu cronies, who are targeting Hindus, to insult and degrade their religion. The false-hood manufacturers categorize homo-sexuality (especially lesbianism) as a Hindu custom and you can observe a demonstration of this in their incessant pyrotechnics on the movie "Fire," where even the names assigned to two characters in the movie, in a lesbian relationship, are the names of Hindu goddesses. The obvious intent is to degrade and desecrate the Hindu religion and to humiliate the Hindu.

2. The latest entrant to this lesbian controversy is the Allah-Swearing Tamil Naidu Moslem Board, that has issued a stern admonition to all Moslem women, not to watch the movie "Fire" at all. This Allah-Swearing Board has judged that it is "Haraam" for Moslem women to watch this film, either in cinema halls, or on TV, or in Video players. They state that because of its lesbian theme, the movie is contrary to Islam.

Contrary to Islam? What a suit-case of fiction!

Lesbianism is not only not contrary to Islam but is a part and parcel of Islam and is the veritable product of its Draconian Monster laws.

3. Quran expressly permits Moslems to acquire slaves through conquests. In Islam, war is prescribed for a Moslem on religious grounds and the concomitant slavery and lesbianism have always been integral and inescapable parts of Islamic wars, as fringe benefits for the Moslem Jehadis and are, therefore, completely conformal with the spirit and teachings of Islam. Mohammad recognized slaves as the property of the Moslem master and nearly all Moslem Sultans kept a large troupe of concubines inside their lavish harems, as permitted by Quranic laws. Inside these harems, lesbianism became an inescapable custom of choice among the sex-starved occupants of the harems, in the dream-house palaces of the Sultans. There is nothing like this wrack and ruin that occurred, at any time and any where inside the Hindu System, throughout its ten thousand year old history.

4. Islamic monster laws, that belong to the dark ages, and the Islamic slave system and its attendant lesbianism, are incontestably the product of the principles of Islam and represent the great wheels of Islam, in its march towards the extermination of the Kafirs (non-Moslem infidels) and their Kufr. Quran gave a divine sanction to the custom of polygamy and concubinage. So, a Moslem can have wives (number limited to four) and can supplement them with half-wives or concubines (no limit on their number) captured in holy wars (Jehad) as those "whom your right hand possesses," perfectly in keeping with the laws of Quran. A Moslem, therefore, engages in this activity with a clean conscience and religious fidelity. This activity and its multiplication was made possible because of the fast-growing Islamic Imperialism. To say that lesbianism is anti-Islamic (as held by the Allah-Swearing Tamil Naidu Moslem Board) is utter non-sense.

5. As a practical reality, it must be realized that concubinage and harems are possible only for those creeds that practice aggressive wars, such as Islam, and annex outside territories from where they can pick male and female slaves. There is nothing like this kind of cataclysm any where in Hinduism, where women are venerated and called as Devis (goddesses). Islam is just the reverse where woman has a lowly position and she exists only for the man's pleasure and because of this permissivity, lecherous Moslems have taken unbelievable liberties with her honor and decorum; all this conducted, of course, in the name of Allah. Consequently, infidel lands that fell to the sword of Islam, provided the lecherous Moslems with a continuous and copious supply of fresh slave men and women (concubines) and they filled their harems for the corporal pleasure of the lecherous Moslem faithfulls, who were doing all this hard work of Jehad in the service of their Compassionate Allah.

6. There are many laws of Islam which are behind the perverted passions (homo-sexuality) in Islam. Islam is a man's religion in which the woman's low position is a matter of Shariat and Quranic religion, and which is a source of utter misfortune and oppression on women. Women are regularly beaten in all Islamic countries. At least 70% of the Moslem husbands regularly beat their wives. There are many many edicts of Islam, including Triple-Talaq etc that create hell for a Moslem woman and causes her plenty of shame for being a woman. A logical question may be asked if these Draconian laws of Islam can be repealed or retracted. The answer is a Big Fat NO. A retraction of these laws is simply not in the cards. This is because the Mullahs and the Maulvies, who run the show in Islam, for reasons of their own, would never agree to a recantation of these laws, however ghastly or repulsive they might be. As a spur of necessity (Americans call it the Hobson's Choice), the Moslem Clergy must keep alive the myth, fiction, and solemnity of these Draconian laws from Allah, and must Dragoon it down the throats of the Moslem faithfulls and their women, in order to keep their Moslem troops in line. This is because a decampment of these Draconian Laws would mean the Dethronement of Islam itself. In this steeplechase, the Mullahs have a strong ally in an edict of the Quran which states that "Once A Moslem (either by birth or by conversion) Is Always A Moslem, No Exceptions Permitted, & Deserters From Islam MUST Be Executed." Quran also says that Allah is the Real Sovereign and in Allah alone are vested the decisions & functions of giving or taking away of authority. What this means is that, no man (and no Moslem) has the authority to repeal or recant these laws. Only Allah can abrogate these laws, no body else can. Period. The Draconian Laws of Islam, which dragoon the Moslems like heck, work with military efficiency because it is backed by an intricate complex of Military-Theocratic Power and by the Dreaded FATWA.

7. In addition to Lesbianism (homo-sexuality among women), gay-ism (homo-sexuality among men) is also very much a part of Islam and can be traced for its sources to the same edicts and the Draconian Laws of Islam that are meted out to its followers and the custom of slavery that is widely prevalent in Islam. It is a famous fact of history that, many Moslem Sultans were very fond of handsome beardless young slaves whom they kept close as pages, personal service-boys, and as gay-companions. Some of the Sultans had an infatuation for these handsome, beardless, slave-boys who received special favors from their masters. This practice of unnatural sexual relations was wide-spread among the Sultans and among the Moslem nobility. There were thousands of such beardless young boys to satisfy the "perverted passions" of the Moslem nobility and Sultans. A Moslem Sultan is unthinkable without his harem and without his troupe of hundreds of handsome young personal slave-boys. All these were needed to serve the Sultan and this custom is a significant fact of Moslem history and is also an integral part of Islam. Islam, of course, categorizes this good stuff as gifts from Allah, as rewards for the Moslem's Jehad. In a Moslem's Paradise, seventy-two Houries and lots of tender young boys are awaiting and available to each Jehadi Moslem. Therefore, in real life, a Moslem does not regard these "perverted passions" as something to sneeze at.

8. Even in our own times, this custom is wide spread in Islam and Moslems are busy trying to imitate the lavish life-style of their earlier Sultans and nobility. In Pakistan, this custom is very wide-spread especially in its NWFP (North West Frontier Province) province. Horror Stories of male-child abuse keep pouring in from the NWFP province of Pakistan. A large part of Pakistan population lives in slums and the young boys of these slums are forced to assist in the economic survival of their family, including service to the clients of the nearby hotels. Hotels use these boys to attract customers and make good money through this process. It is worth noting that customers (practitioners of this perverted sex) neither consider this practice bad nor against Islam; they continue to prey upon these working tender young boys as well as swear by Allah as fidelty to their faith of Islam. The hotels encourage this trade and the offering of these services to their customers. In civilized societies, such practices are classed as "Child-Molestation." In Islam, this custom is well-established, well-accepted, in fact is a tradition to molest boys (after all Islam's Laws came from Allah, Allah knows everything and Allah can never be wrong!). Boys are, therefore, kept specially for sex. The rigid segregation of men and women in Islam augments the growth of these Islamic practices of perverted sex. What about the rescuing of the children who are the victims and targets of this abuse? No body in Pakistan is concerned about it nor is anybody talking about it. Pakistanis prefer to hide it and keep it hidden...their Mullahs/Maulvies tell them that Allah will take care of them and of everything else!

9. Because of this unworthy and perverted homo-sexual record of Islam, it is utter rubbish to portray Lesbianism or Gay-ism as a Hindu institution. This depiction of Hinduism is a shameful lie and a disgraceful deception hatched by Islam and its bunkmates, and should be rigorously opposed and unsparingly condemned by all civilized human beings.

tsarkon reports OBAMA will BANKRUPT THE USA (-1, Offtopic)

Anonymous Coward | more than 5 years ago | (#27300593)

- Chairman Barack Hussein "The Teleprompter" Obama is deeply connected to corruption, Rahm Emanuel (Radical authoritarian Statist-Zionist whose father was part of the Murderous Civilian Killing Israeli Terrorist Organization known as IRGUN), Connected to Rod Blagojevich (Rahm inherited Rod's federal-congress seat), Connected to Ayers, a man who promotes the concept that civilian collateral damage is ok in a war against freedom, Preacher Jeremiah Wright, who is himself a black-elitist who wants all the people who largely "pay the freight" to suffer, 31 million on food stamps, more blacks are in prison and on food-stamps per capita than anyone else. The problem with Wright is simply this: the facts are "racist."
- Obama: Racist, AIPAC-Zionist, Corrupted and a Traitor and a Liar who can't even produce a valid birth certificate (which is not a certificate of live birth)
- Raytheon lobbyist in Pentagon
- Goldman Sachs insider second in command at Treasury.
- Cabinet has had several nominees and appointees with multiple tax fraud issues.
- The head of the IRS and the head of the Treasury, Geithner, is a Tax Cheat
- Lied about no lobbyists
- Lied about having a new degree of accountability and a SUNSHINE period of new laws, he has signed bills with little or no review at whitehouse.gov as promised.
- Appointed a second amendment violating Rich-pardoning treasonist Eric Holder as AG, the top cop of the USA, a man who helped a fugitive evade justice.
- Has not put a dime in for a single new nuclear power plant but wants to help bridges and roads to promote more driving.
- Obama, Blagojevich and Rahm Emanuel have a LOT to hide. They literally lived next to each other, Rahm had (until being Chairman Obama's Chief of staff) Blagojevich's old federal congressional seat. Blagojevich helped Chairman "The Teleprompter" Obama cheat his way to the Illinois senate by getting other candidates thrown off the ballot in Illinois. Why do you think Blagojevich was so mad? Obama DID owe him, big time. Rahm and Obama are using Blagojevich and trying to cut his head off to keep him away.
- Tony Rezko, Iraqi Arms Dealer Nahdmi Auchi, and of course Aiham Alsammarae. Chairman "The Teleprompter" Hussein Obama is so corrupted its a joke.
- Fools and "useful idiots" twist the pie charts by leaving welfare, workfare, interest on debt, social security, Medicare and Medicaid out and focusing only on non-whole "discretionary" pie charts.
2007 high level pie chart, Federal Budget, USA [wikimedia.org]
2009 Pie chart, detailed, Federal Budget, USA [wikimedia.org]
- Chairman Obama is drastically increasing spending and creating more entitlements that will make the US less competitive (especially against China, India, East Europe/Russia). This will be a huge disaster and change you can believe in will strap you and your grandkids with more debt. No taxation without representation? Obama is spending money for the next two-three generations and they can't even vote yet, or even have been born.
- An alternative to the dollar and a forex and a reserve currency came up at the last G20 meeting. The world will not take faith in Obama's liar-socialist spending and welfare state, why should the taxpayers (plebian citizen-slaves of a police state).
- The spending going on now vastly eclipses all previous spending. In fact, the massive trillion plus debts is a thing of the 80's onwards. Congress signs the checks, remember that Year after year, as egregious as the pentagon spending is, that the social spending is completely a waste of money and it is unfunded over the long term. Eisenhower built the interstates, the US could build a new power infrastructure with this money but instead is being pissed into creating more of an entitlement system that is STILL unfunded, and without massive poll-taxes and far more aggressive progressive taxes, could NEVER be funded.
- The budgeting being done today were recently reported by a non-partisan auditing commission will lead to about 10 TRILLION in new debt over the next 10 years. Obama is going to double the national debt while doing nothing to address the unfunded debt obligations of Social Security.
- Clinton appointed David Walker of the GAO, he quit, the unfunded debt obligations have rendered the USA insolvent according to accounting standards.
Taxpayers on the hook for $59 trillion [usatoday.com]
US Public Debt Unfunded Debt Obligations [wikipedia.org]
- Most of the world population gets NOTHING from their governments, or a very bare minimum or services that benefit only the upper echelons of society. However, the liar Chairman Obama says we need his universal "state-hospital" rationed health care to be competitive. Bull. China and India give nothing, and they are the biggest threat to the American worker. By forcing healthcare and higher taxes, Americans will be less competitive.
- If you think 60% tax rates end to end (income, accounts receivable tax, building permit tax, CDL tax, cigarette tax, corporate income tax, dog license tax, federal income tax, unemployment tax, gasoline tax, hunting license tax, fishing license tax, waterfowl stamp tax, inheritance tax, inventory tax, liquor tax, luxury tax, Medicare tax, city, school and county property tax (up 33 percent last 4 years), real estate tax, social security tax, road usage tax, toll road tax, state and city sales tax, recreational vehicle tax, excise tax, state franchise tax, state unemployment tax, telephone federal excise tax, telephone federal state and local surcharge tax, telephone minimum usage surcharge tax, telephone state and local tax, utility tax, vehicle license registration tax, capital gains tax, lease severance tax, oil and gas assessment tax, misc internet sales tax and many more taxes that I can't recall at the moment) will make the US competitive, along with compulsory programs to provide everyone with health care is going to make the US competitive in the age of India and China, you are a joke.
- As the US nationalizes (read: rations healthcare) to the least common denominator of affordability without regard to efficacy, people with money will simply look into medical tourism so those with money can go to medical parks in India and get real health care. Those who have lived in Canada or in the UK can tell you "free" healthcare is NOT a panacea. If you think this, you are again, a useful idiot. The NHS in the UK has given bad blood and Hepatitis and AIDS blood to people, and Jade Goody who just died was misdiagnosed twice resulting in her death (She was all cleared twice of cervical cancer which she just died of). The NHS in the UK is not able to be sued or held accountable. Neither will Chairman Obama's rationed health care service for America.
- Sorry to bust the socialist bubble-lie, but support of these types of policies will simply lower the standard of living in the USA, particularly for the middle class. At least at the end of the Eisenhower projects the USA got roads to show for the spending, and with this new spending, the USA could have built power plants that get the USA out of the middle east, but the age of government for the sake of government is upon us, and the useful idiots line up and believe empty promises.
The pentagon (and Bechtel, Kroll, Bluewater, Halliburton, etc) could get less than half of what they get today, but that will fix nothing fundamental in terms of government spending. It is simply not enough to make a difference when compared to the Medicare, Medicaid, welfare, workfare and social security entitlements.
See: YouTube - US Government Immorality Will Lead to Bankruptcy [youtube.com]
- If Obama thinks its ok to lie to 300 million people about being able to "take care of them" without even being honest about what that care would look like, then being an idiot and believing in Obama is for you.
- The US Government already have over 50% of the budget on Medicare, Medicaid, welfare, workfare and social security. Socialists: Good job on that one, its working great. Solution to the current near-collapse-due-to-over-spending: add more unfunded entitlements!
- You Socialist-liars can break my spirit and my financial back to force me to "need" a federal government that is turning this country into a police state and turn it into a quasi-socialist lie, but I will, I must put up a fight. I have kids to educate and feed, and the stuff you sell (which is failing to various degrees everywhere else as implemented) is simply forcing a culture of failure on a once great, libertarian free country.
- I will not be complacent with your "change," and there will be a point where civil war will become an option. See how hard you can push before you get it. How much more than half can the truly productive workers in this country afford to pay. Keep pushing to find out how to start a civil war.
- The socialist-lie of a plan will not work, its not fundable, it WILL destroy the currency to fund it, and its really as simple as this: if this insanity is funded by borrowing from the US's economic and military adversaries then Obama and his socialist cabal is NOT fit to administrate society. Rome fell. Kings who mis-manged their treasuries all fell. Every example of unhinged spending leads to the same result: systemic collapse.
- Obama and his sycophantic lunatics would want to have a civil war to get Chairman Obama's way and force the socialist-lie system on my already tax paying law abiding ass. And as far as "no new taxes" for those under 250k, its a lie, the tax is called inflation, which is set to begin just about now that the Chinese wont want the USA's worthless treasuries to fund the socialist-lie fantasy (one that COMMUNIST China doesn't even try and sell to its people!)
- Chairman Obama's numbers don't add up. There is a $59 trillion dollar hole (UFDO) in social security alone. AIG $150 billion here, TARP $350 billion there. $800 billion for a highly dubious stimulus package. Another one on the way. $59 trillion hole in the balance sheet IGNORED. China saying they aren't going to buy treasuries, Clinton clamoring to find buyers now. $3.6 trillion dollar budget, potential military action on Mexico, Iran still a "terrorist state" at the behest of the AIPAC, spending up, dollar about to fall, inflation over time since Breton Woods extremely easy to document, yet, the socialist-liars question when the numbers (the Federal Government numbers) simply don't add up to the point where if the US-GOV was a company it would be insolvent.
  -How dare the taxpayers question what Chairman Obama's drastic spending increases are going to do to the purchasing power of our savings because Chairman Obama wants to recklessly spend and try to maintain and American empire AND guarantee a standard of living, and Chairman Obama doesn't even want to build a single nuclear power plant to do it? Chairman Obama must be a complete and total lunatic moron.
- Obama is either a negligent idiot or an unhinged maniac with delusional fantasies. Meanwhile, Chainman Obama's tax dodging Treasury Secretary has 17 unfilled positions, the Treasury Dept. isn't even functioning at this point.
- "General welfare" in the constitution was, according to the man who wrote it, Madison, meant to be extremely limited in scope. The federal government per the constitution doesn't even have the enumerated POWER to deal with economic messes. A lot of these "POWERS" were created while there is a crisis to dupe the public into accepting an un-constitutional authoritarian regime as the government and to usurp authority over the people.
- The USA is a constitutional republic. A democracy is two wolves and a sheep voting to eat a sheep. Also a constitutional republic isn't about using a barely-majority or a plurality to stuff your (un-fundable disastrous) crap down the disenfranchised other-half's throat.
- With Obama's authoritarian corrupted criminal (aiding and abetting a criminal in flight of prosecution, Rich case) Eric Holder in charge, we won't have our inalienable and enumerated rights to firearms much longer. For a constitutional law expert, Obama must have never read the federalist papers or he would simply hand himself as a traitor.
- The arbitrary expansion of "general welfare" is not only unconstitutional, it may very well lead to a serious conflict on the issue.
- Here is a debate on general welfare and how stuff like this came to pass, but was clearly no intended by the authors of the document of root law.
In Federalist No. 41, James Madison asked rhetorically: "For what purpose could the enumeration of particular powers be inserted, if these and all others were meant to be included in the preceding general power?" (In reference to the general welfare clause)
So strongly did the founders believe that "general welfare" wouldn't be expanded as written:
In Federalist No. 84, Alexander Hamilton indirectly confirmed Madison's point. (That the "general welfare" clause was "clearly" nota free pass for government)
Hamilton argued that a bill of rights, which many were clamoring for, would be not only unnecessary, but dangerous. Since the federal government was given only a few specific powers, there was no need to add prohibitions: it was implicitly prohibited by the listed powers. If a proposed law a relief act, for instance wasn't covered by any of these powers, it was unconstitutional.
"why declare that things shall not be done which there is no power to do? Why, for instance, should it be said, that the liberty of the press shall not be restrained when no power is given by which restrictions may be imposed?"
Hamilton goes on to argue that making Amendments (e.g., enumerating Free speech, press and assembly) and enumerating the 'right' would have the following effect:
(A bill of rights) "would furnish, to men disposed to usurp, a plausible pretence for claiming that power that is, a power to regulate the press, short of actually shutting it down. "
"With respect to the words 'general welfare,' I have always regarded them as qualified by the detail of powers (enumerated in the Constitution) connected with them. To take them in a literal and unlimited sense would be a metamorphosis of the Constitution into a character which there is a host of proofs was not contemplated by its creators." --James Madison [The US Supreme Court has found the meaning of "general welfare" in the Constitution to be much more elastic than did Mr. Madison. But as the "author of the Constitution," what does he know?]
James Madison, when asked if the "general welfare" clause was a grant of power, replied in 1792, in a letter to Henry Lee,

If not only the means but the objects are unlimited, the parchment [the Constitution] should be thrown into the fire at once.

"...We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness. That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed. That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it...it is their right, it is their duty, to throw off such Government , and to provide new Guards for their future security. ...--The Declaration of Independence
- Wrong, monetizing failures causes more. Japan showed us this for decades. But hey, Chairman Obama thinks you can fix a problem DECADES in the making with a quick fixer-upper, he is screwed in the head.
- The complaints are with the Federal government (in general) since Breton Woods. The Federal Government and Obama's minions STILL didn't listen to David Walker, a Clinton appointee and former head of the GAO. This isn't about political parties anymore morons!
- Show me a single federal budget that was less than the previous. If this $3.6T budget goes, its never coming back barring systemic collapse.
- The United States Federal Government, The United States Federal Reserve, and the banks which were enabled to continue down reckless paths by a quasi government agency known as the Federal Reserve whose actions are not subject to congress and whose members are unelected. This situation is untenable and unconstitutional.
- Every inflationary road taken in history ends in collapse. Keynesian policies are widely regarded as no longer workable.
- Inflation is a tax: What ignorant tax and spenders don't take into account here is the relative percentages of people's wealth (both net and gross) and the costs of owning and maintaining houses, cars, standards of living.
- Inflation via deficit spending is going to make it such that you will be paying a lot more by percentage of your income to maintain a given standard of living. Obama's arguments are so poorly thought out and seek to blame "Republicans" for the mess, its really simply laughable - the needs cleanup now, not worsening.
- You can't spend your way out of a hole if the creditors (e.g. China) start telling the USA they won't buy. It is that simple. Now America starts to have to collateralize the debt with assets. The USA will be selling off chunks of American assets to back the new debt. One day, it may even be necessary to sell Alaska back to Russia because no one will take greenbacks to prop up a failing version of a modern Rome.
- Ah, here we go with the Matthew Lesko arguments. [lesko.com]
Interest rates were on the rise before the government stepped in with free money for everyone (the fine print of course indicate massive strings attached).
Other economies, for example, India, have the central rates set to far more reasonable/realistic rates (at the moment ~ 8+%), which is still tends to be too low, but shows that if you need someone else capital you need to pay a premium for it, and given that capital is in short supply, it would stand to reason that a premium must be charged for it.
The problem is the unrealistic growth rates of mature economies don't allow for profiting via growth projections (rather than simply earning money). So the government steps in, turns on the free money spigot, gets the interest rates for savings down in the 1-2% range while diluting the value of the whole currency in order to prop up dying companies that ran the business like a Madhoff Ponzi scheme.
- The Republicans aren't solely responsible for the crisis as Obama's minions would have you believe, congress is (no particular congress), the Executive of the US government (no particular one) and the US Federal Reserve System are all at fault.
- Fundamentally, the government is trying to fix the prices of various things to "make it all work." This pulling on the invisible hand is a fools venture. It was predicted long ago the housing collapse (and those, such as myself, in the know, wished while realizing the housing collapse coming that we were wrong for everyone's sake - but the truth is the truth) . It may be that the Austrian (von Mises) economists will ultimately be proven right.
- We are a nation of partially educated whiney grabby idiots, and we got the government that represents this. The Chinese, India and other up and coming nations will show no mercy for this arrogant abuse of our status as the world's forex reserves.
- War and asset sales will continue to be the only option for this scheme until it is corrected at the core. And to say that the government has already averted a depression by doing what they did (most of the monies injected wont be "felt" for some time), is just arrogance and stupidity. Price fixing prolonged the Great Depression. Price-fixing (or attempting to) houses will do the same, but probably worse.
- Obama's minions simply don't care if the US is bankrupted and rendered insolvent, they just want a say in how its done, presumably to "feel safe." Rather selfish.

"They who can give up essential liberty to obtain a little temporary safety, deserve neither liberty nor safety." AND "Those who would give up Essential Liberty to purchase a little Temporary Safety, deserve neither Liberty nor Safety." -- Benjamin Franklin (Possibly Richard Jackson)

- Everyone better realize that inflation will pay a major role in funding un-fundable fantasies, wiping the savers and the middle class out. The problem is, that other countries are growing tired of making our Federal Reserve notes worth something by buying our debt as treasuries. Obama's minions talk about spending, but in order to "get what YOU want" you will sell debt to potential economic and military adversaries? Real bright. What's really sad is that despite David Walker being an authority on these issues, people refuse to even watch him and listen to what he is saying.
- On the success of Canada and its form of Socialism: A huge country like Canada with massive amounts of uranium and tar sands and natural resources and a huge land mass with a scant 30 million people is an order of magnitude less of a problem to manage than a country with 10x its population, a serious leaky southern border, backfiring aggressive foreign policy, particularly with Iran, and the US is competing with countries like India and China whose middle classes are larger than the US's entire population. The top 5 students in every Indian and Chinese primary school out numbers all the kids in primary school in the US. Canada is a idyllic island, the USA is front and center in an all out economic and political clash of ideologies.
- Cap and trade (and pollution control for solving global problems) will never work unless the top 10 countries in the world (in terms of both GDP and manufacturing capacity and population) are on board. Period end. If the world doesn't quickly move to nuclear now and fusion shortly, it is OVER possibly not if every home on the planet gets a wind vane, but that seems unlikely to happen (since its possible now).
- Keynes calls it "the paradox of thrift" and suggested that policies forcing people not to save is a "good idea." The guy wanted people spending all the time, or if he didn't, he never conveyed that to his protégés well enough for them to not do what they are doing. Right now the plebeians in the US are actually stashing cash, and everyone from Obama to the media is trying to get people to spend spend spend. The best thing for the long term is for people to prepare for the coming hell, not set out with no reserves.
- I have seen Keynes invoked to justify nearly every bad move in the past decade, and its warming up to be a potential currency collapse, the collapse of the US Treasury and Federal Reserve notes, and a collapse of the NYSE. And then they invoke Keynes to suggest the best way out of the mess is to spend out of an already near-critically debt massed black hole.
- A house is run like a town is run like a country or business is run like a state is run like a government. If there are things the government is doing that would either force your home into bankruptcy or into jail via fraud charges, then the government and banks shouldn't be operating in that fashion. A certain degree of stretchy liquidity is in order, but in terms of percent of GDP, there is no way of justifying what they US has now.
- Iceland failed at 850 percent debt to GDP. The US is at 350 and rising. It is not a good thing at all.
- What is happening to the dollar as a forex standard. [youtube.com]
- March 19, 2009 C-SPAN - "Let's Quit Destroying Our Dollar!" [youtube.com]
- HR 1207 (A bill to make the Fed more accountable and to answer questions regarding the dollar policy) [loc.gov]

Title: Obama sidetracked by fiscal mess, but presses on [yahoo.com]
"Being heard above the din may prove difficult. Lawmakers are wrangling over taxing people who got big bonuses and worrying the president's budget could generate $9.3 trillion in red ink over the next decade."
- Kremlin to pitch new global currency [infowars.com]
Russia proposes creation of global super-reserve currency

Holy crap, even the Russians and Chinese get it. Strange days are here.

Exon skipping (-1, Redundant)

XxtraLarGe (551297) | more than 5 years ago | (#27300623)

A-hah! I always knew Big Oil was behind muscular dystrophy! Just one more reason to switch to domestic sources of energy.

Re:Exon skipping (0)

Anonymous Coward | more than 5 years ago | (#27301281)

Like domestic oil?

Re:Exon skipping (1)

XxtraLarGe (551297) | more than 5 years ago | (#27301393)

Like domestic oil?

I was making a play on words with Exon/Exxon. Clearly, my attempt at humor this morning has flown way over the head of the moderators..

Does this mean... (2, Funny)

Jonah Bomber (535788) | more than 5 years ago | (#27300645)

...the end of Labor Day Weekend Telathons? What will Jerry Lewis do now? Guess my 25 cents in a fireman's boot actually worked.

Re:Does this mean... (1, Insightful)

Anonymous Coward | more than 5 years ago | (#27300879)

What will Jerry Lewis do now?

I don't know about the immediate future, but I guess this means he gets to die knowing that he has made a positive contribution to humanity as a whole.

Is it heritable? (4, Interesting)

PotatoFarmer (1250696) | more than 5 years ago | (#27300665)

I'd be interested to see whether or not the "patch" is heritable; the article doesn't mention it. In any case, it's really impressive work.

Re:Is it heritable? (1)

sexconker (1179573) | more than 5 years ago | (#27300737)

I doubt it, especially from women.

Re:Is it heritable? (2, Informative)

PotatoFarmer (1250696) | more than 5 years ago | (#27301033)

I guess it would depend on the potential methods of inheritance. If, in addition to directly modifying the production of male sperm, the patch could be delivered through the placenta to a fetus similar to how antibodies are transferred then it could still be heritable through the female.

That all being said, I'm not a biologist, so it's entirely possible that what I've described can't actually happen.

Re:Is it heritable? (1, Informative)

Anonymous Coward | more than 5 years ago | (#27300841)

I'd be interested to see whether or not the "patch" is heritable; the article doesn't mention it. In any case, it's really impressive work.

It's not.

Re:Is it heritable? (1)

Shikaku (1129753) | more than 5 years ago | (#27301187)

The patch will have to be in either the eggs of the female (very unlikely it will reach there) if it even COULD work at all because of the way eggs are special (giant, hard large shell) or in the site where male sperm does its meiosis; sperm cells are made by dividing like mitosis then dividing again to form 4 cells with half the DNA. It's possible in males, but very unlikely in females.

Re:Is it heritable? (1)

MarkRose (820682) | more than 5 years ago | (#27301279)

That's okay, just call Tank and he'll upload one! "Tank! I need a patch!"

*goes back to bending spoons*

Re:Is it heritable? (2, Informative)

vivin (671928) | more than 5 years ago | (#27301711)

IANAG (IANA Geneticist), but from what little I know about genetics, I doubt it is heritable. The only way something can be heritable is if it modifies any of the germ cells (sperm or ova). In fact, some of the "junk" DNA that we have are actually inactive sequences of ancient retroviruses (ERVs - Endogenous retroviruses [wikipedia.org]) that infected the germ cells in our ancestors.

Patch Tuesdays? (1, Funny)

Anonymous Coward | more than 5 years ago | (#27300815)

If this does work, will our descendants have to deal with a more personal variation of Patch Tuesdays??

Re:Patch Tuesdays? (3, Funny)

SnarfQuest (469614) | more than 5 years ago | (#27301001)

Will they usee same level of quality control as Microsoft?

Re:Patch Tuesdays? (1)

Sinning (1433953) | more than 5 years ago | (#27302433)

It would be rather interesting to see people limping around every other Tuesday because of problems with the weekly patch.

I read the headline as... (4, Funny)

Anonymous Coward | more than 5 years ago | (#27300825)

For some reason, I read the headline as "Scientists Reverse Muscular Dystrophy in Frogs". Reading that, I thought, "Well no wonder the French love Jerry Lewis".

Great News (5, Informative)

Nos. (179609) | more than 5 years ago | (#27300877)

I just found out that two nephews of three are positive for DMD. This basically confirms that my sister-in-law is a carrier. We're in the middle of trying to determine if my wife is a carrier, and thus if our two sons are at risk. To say the least this is a very stressful time in our lives, and there are no quick answers. However, seeing a big jump like this in treatment is great news.

Re:Great News (2, Insightful)

JorDan Clock (664877) | more than 5 years ago | (#27301433)

Pray to dieties, sacrifice every living animal you can get your hands on, and avoid every single bad luck superstition. My brother has DMD and at the age of 30, he can't even feed himself anymore. I sincerely hope for the best with your children.

Re:Great News (1)

Nos. (179609) | more than 5 years ago | (#27301943)

We were waiting to get genetic testing done on my wife, but they've come back and said get CK levels done on the kids first. We're hoping to get those done this week. We did get a CK level done on my wife, and hers was 320. Given she's physically active, it pretty much doesn't tell us anything.

The one positive is that no one else on my wife's side of the family has had, or shown symptoms of muscular dystrophy, which leads me to believe that her sister became a carrier as a result of a mutated egg, and did not inherit it. From what I've read, 33% of cases start that way, which is good news for my wife and I. In any case, its going to be hard to watch our nephews since we are quite close.

Re:Great News (2, Informative)

anderesa (445239) | more than 5 years ago | (#27303425)

Dear Andrew,
as a daily reader of Slashdot and also father of four young kids, two of them having Duchenne, I'm surprised that this terrible desease is discussed among this community.

Unfortunately, the discussion doesn't go very deep with few interesting threads. I cross my fingers for your family. My wife also is a carrier but my two sister-in-laws. In fact, we found out that my wife got the defect (3 Exons are deleted on one X-chromosom) from her mother but she's been the only one among five kids to inherit the defect X-chromosom. I've also read in several places that the odds of being a carrier are 66% if one of your kids has the genetic defect

Last, I'd like to point you to some great reports about latest research incl. exon skipping techniques. They are all written in easy language understandable by parents and other people without a PhD in biochemistry.
http://www.duchenne-information.eu/home-en.htm

Take care
--Sam

Original Article (2, Interesting)

Elenseel (1510087) | more than 5 years ago | (#27300927)

Is there a way to get the original article published by the scientists who developed the technique? My mentorship is heavily rooted in genetic analysis, so I'm interested in these kinds of things.

Re:Original Article (0)

Anonymous Coward | more than 5 years ago | (#27301995)

http://www3.interscience.wiley.com/cgi-bin/fulltext/122260425/HTMLSTART

I can see it now (3, Funny)

Rayban (13436) | more than 5 years ago | (#27300957)

# patch -p0 < cure-md.patch

File to patch: chromosone/18
patching file chromosone/18
Hunk #1 FAILED at 47.
Hunk #2 FAILED at 128.
Hunk #3 FAILED at 308.
Hunk #4 FAILED at 316.
Hunk #5 FAILED at 328.
Hunk #6 FAILED at 342.
Hunk #7 FAILED at 397.
Hunk #8 FAILED at 708.
Hunk #9 FAILED at 1268.
9 out of 9 hunks FAILED -- saving rejects to file
chromosone/18.rej

VERY FUNNY!!! Except... (0)

Anonymous Coward | more than 5 years ago | (#27301537)

it's chromosoMe!

File to patch: chromosone/18
Path chromosone/18 not found.

So that's how the Rage Virus will get made! (1)

Capacitor (241918) | more than 5 years ago | (#27301009)

I'm heading for the mountains with my shotgun. Be sure to act intelligent if you see me or else I'll have to assume you're infected!

Re:So that's how the Rage Virus will get made! (1)

elrous0 (869638) | more than 5 years ago | (#27301605)

According to Battlestar Galactica, its those damn Japanese robots that should worry us. Leave the Roomba behind when you go.

Re:So that's how the Rage Virus will get made! (1)

PrescriptionWarning (932687) | more than 5 years ago | (#27302101)

actually the Japanese are the ones making robots with the intentions of making them friends, whereas others tend to militarize them and think of them as becoming our new overlords. That's possibly why they ended the series showing only the robots that weren't killing machines.

All this animal testing good for vets? (1)

wjh31 (1372867) | more than 5 years ago | (#27301049)

does these sort of medical tests on animals end up with better treatment of animals aswell by passing the info onto vets or is it generally not considered worth it for mans best friend.

Re:All this animal testing good for vets? (1)

fuzzyfuzzyfungus (1223518) | more than 5 years ago | (#27301197)

In a substantial number of cases, human therapies do become available for animals. They even have vets that specialize by disease area instead of by animal type(ie. Veterinary Oncologists vs. Large animal or small animal vets). This is also why you can now get animal health insurance.

Re:All this animal testing good for vets? (1)

TheSync (5291) | more than 5 years ago | (#27301623)

In a substantial number of cases, human therapies do become available for animals.

It is easier and cheaper for these therapies to become available for animals because of less regulation. For example, you can clone animals today, but cloning people is illegal...

Slashdot makes my day (5, Insightful)

Naked Jaybird (1190469) | more than 5 years ago | (#27301259)

As one diagnosed with Becker's MD, a milder form of DMD, I, for one, welcome my new exon-skipping overlords. For those of you who are wondering if you should go to the gym, run, jog, shoot hoops, or play soccer today. I give you the same advice that I give to my three boys: Run, because you can.

Re:Slashdot makes my day (1)

sherriw (794536) | more than 5 years ago | (#27301503)

That, Naked Jaybird is an EXCELLENT comment. I copied it down and put it next to my 'work out plans' that I've been neglecting.

Re:Slashdot makes my day (0)

Anonymous Coward | more than 5 years ago | (#27303779)

Will you also heed the advice of someone with a liver disease?

Drink, because you can!

Re:Slashdot makes my day (0)

Anonymous Coward | more than 5 years ago | (#27302261)

Randal
"I can't help it. Guy pisses me off."

Dante
"What's the blog?"

Randal
(while cooking)
"Wheelieblog.org. It's this fuck in a wheelchair who's alway's preying on everyone's sympathies and writing these long diatribes about how he'll never walk again, and how walkers should appreciate the blessings of their functioning legs."

Dante
"That "diatribe" as you call it sounds more like some poor, crippled guy pouring out his heart and feelings.

Randal
Oh, fuck him - trying to guilt me into walking around more because he's all gimped out. What kinda mind-fuck is that shit?
(dumping fries)
So i've been getting into it with him on his board - throwing it back in his stupid cripply-boy face about how much I love to just sit around, and how i'd rather drive to the end of the block than walk.

Dante
"the guy's in a wheelchair!!"

Randal
"Yeah - that's why I call him "Cripply-Boy"
(handing bag to customer)
"Have a good one!"

Re:Slashdot makes my day (1)

gurps_npc (621217) | more than 5 years ago | (#27303617)

By the way, if you read the article, tehy don't really cure DMD. They transform DMD into Becker's MD, what you have.

In other words, You are the new exon-skipping overlord

Re:Slashdot makes my day (1)

Naked Jaybird (1190469) | more than 5 years ago | (#27304039)

Beautiful. Is this the first time we have had a real overlord on Slashdot? Bow down to me! But seriously, what I have is a single point mutation, so skipping errors is a reason to be optimistic. I do not know if skipping a single point will increase dystrophin in people with Becker's MD, but skipping an error and running execute something else would be the winner. Actually, what I need is a substitution regex.

Re:Slashdot makes my day (0)

Anonymous Coward | more than 5 years ago | (#27303953)

And as someone with Thomsens MD I also welcome this news. Although my varient is not as severe as others, it is annoying and seems to be getting worse as I get older.

I really hope this can make people with MD have a better quality of life, once it's ready and 'safe'.

Side effects? (1)

Em Emalb (452530) | more than 5 years ago | (#27301449)

Will this "patch" remove the "I'm going to butt-scoot across your white carpet" and the "I'm drooling cause you said the word treat" genes as well?

Or, heaven forbid, will this treatment have Viagra-like side-effects?

Re:Side effects? (0)

Anonymous Coward | more than 5 years ago | (#27301973)

Dang, are you talking about the dog or human version of the treatment? Because... ewww.

The problem with patches... (1)

Gricey (154787) | more than 5 years ago | (#27301597)

... Is that they end up regressing, will someone just bite the bullet and fix upstream?!

What the? (0)

Anonymous Coward | more than 5 years ago | (#27303127)

How come this article isn't showing up on /.'s main page? I happened to notice it from RSS feed on my Goggle homepage, but it's not on the main page anymore?

Results based on? (1)

Anachragnome (1008495) | more than 4 years ago | (#27304637)

The videos? I certainly hope they based their findings on more then that.

Correct me if I am wrong, but the untreated dogs shown at the beginning of the video do not appear to be the treated dogs shown in the latter half of the video. The age given for one of the treated dogs is actually 3 months younger then either of the untreated ones shown.

So, what exactly is the video supposed to portray? It is impossibly to make any comparison based on the video because there is no "before" and "after" nor do we have the opportunity to see ANY of the dogs in more then one state, treated or untreated.

All I see is several dogs, never more then once, suffering varying degrees of motor skill loss.

Am I missing something here?

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