Beta

Slashdot: News for Nerds

×

Welcome to the Slashdot Beta site -- learn more here. Use the link in the footer or click here to return to the Classic version of Slashdot.

Thank you!

Before you choose to head back to the Classic look of the site, we'd appreciate it if you share your thoughts on the Beta; your feedback is what drives our ongoing development.

Beta is different and we value you taking the time to try it out. Please take a look at the changes we've made in Beta and  learn more about it. Thanks for reading, and for making the site better!

Method To Repair Damaged Adult Nerves Discovered

kdawson posted more than 4 years ago | from the reconnecting-the-dots dept.

Medicine 128

An anonymous reader writes "Researchers have discovered a promising method to regrow damaged nerves in adults. Brain and spinal-cord injuries typically leave people with permanent impairment because the injured nerve fibers (axons) cannot regrow. A study from Harvard and Carleton University, published in the December 10 issue of the journal Neuron, shows that axons can regenerate vigorously in a mouse model when a gene that suppresses natural growth factors is deleted. Here is the journal article (subscription required to view more than the abstract)."

cancel ×

128 comments

nerve growth unsuppressed == tumors? (0)

wherrera (235520) | more than 4 years ago | (#30404000)

watch out guys

Re:nerve growth unsuppressed == tumors? (5, Informative)

wizardforce (1005805) | more than 4 years ago | (#30404088)

Tumors form through uncontrolled growth of cells. Axons are the connections between nerve cells that conduct the nerve impulses. There is no cell division proliferation going on here.

Re:nerve growth unsuppressed == tumors? (2, Interesting)

Palpatine_li (1547707) | more than 4 years ago | (#30404312)

you don't regrow broken axons. Neuron cells with broken axons die. All the things about neural regeneration require new-born neurons from glia-like stem cells.

Re:nerve growth unsuppressed == tumors? (5, Informative)

orangesquid (79734) | more than 4 years ago | (#30405152)

The research out there on neural regrowth in adults is very interesting, because, yes, the classical empirical evidence is that damaged neurons go into apoptosis and are cleaned up by glial cells.

My girlfriend has atypical trigeminal neuralgia and underwent an unsuccessful microvascular decompression on the brainstem (wherein a venous structure was deconstructed and cauterized, a venule was padded with teflon, and a minor arteriole was resectioned and cauterized), followed by a more-successful partial sensory rhizotomy to resection the nerve in Meckel's cave via a 60% cut that ideally would hit most of the group-C fibers. The outcome of the rhizotomy is interesting, because it seemed to take care of the mandibular nerve pain while leading to a very odd outcome. In the vast, vast majority of partial sensory rhizotomies on cranial nerves (meaning more-or-less the ~99% who do not have the horrid-sounding outcome known as anaesthesia dolorosa), the loss of sensation eventually diminishes, as the nerve undergoes restructuring. There seems to be very little information in popular medical literature on the restructuring process, and as I don't have access to any specialized journals (for neurology, neurosurgery, etc.), I cannot find much information; however, it seems to perhaps involve rapid branching of the dendrites in parallel with apoptosis and glial clean-up of damaged neurons. In >90% of rhizotomies, there is little discomfort during this process. My girlfriend is one of the "lucky few" (and by that I mean that her neurosurgeons, Dr. Sekula and Dr. Jannetta, who himself pioneered microvascular decompression and other techniques for trigeminal neuralgia of both types and various types of hemifacial spasm, at Allegheny General Hospital, said they could not even remember the last time they had seen the effect she is experiencing) to have severe discomfort during the restructuring process. This discomfort is a dysthesia characterized by intense sensations of all types from the cranial nerve. She is experiencing sensations of pressure, nociception, touch, and proprioception in all branches of the trigeminal nerve, meaning not only the major three branches (ophthalmic, maxillary, and mandibular), but the minor branches out of Meckel's cave as well. In addition to that, she is having branching across into adjacent cranial nerves. These sensations range from moderately intense to maximally intense (meaning she is experiencing at times the same sensations someone would have if their skull was being crushed to pulp, or face was being cut deeply open in many places, etc.), but at least they can be controlled somewhat by extremely high levels of antiseizure medication. Between the sensations and medication, though, she is effectively completely disabled while the nerve undergoes this type of healing. The good news is that her neurosurgeons have never seen, either themselves or in any journals, a case of this that does not resolve when the restructuring reaches its end-stage, which occurs after six to twelve months. The intermediate time, though, is Hell for her. I would love to see more research done on this, as I would be curious to see if various signalling mechanisms are not genetically nominal in the <10% of cranial nerve rhizotomy patients who have this type of post-procedural effect.

Please, let's continue the research on SOCS3 here, and the other research being done out there on the various other known signalling mechanisms [wikipedia.org] .

Re:nerve growth unsuppressed == tumors? (0, Flamebait)

hesaigo999ca (786966) | more than 4 years ago | (#30406270)

>These sensations range from moderately intense to maximally intense

You know, with this type of affliction, even though temporary, would lead me to conduct
my own experiment, had you tried stimulating her clitoris while this was in effect happening,
I wonder if the sensations being maximized, would have overpowered all others
and made the only sensation that which was the most pleasing (due to the endorphins)

Re:nerve growth unsuppressed == tumors? (0, Flamebait)

BJ_Covert_Action (1499847) | more than 4 years ago | (#30406804)

had you tried stimulating her clitoris while this was in effect happening....

Perhaps you really are so very interested in the neuroscience that this seems, to you, like a pragmatic and reasonable 'experiement.' However, the parent post mentioned later in his discussion that the lady is undergoing, from time to time, experiences equivalent to feeling your skull crushed or your face deeply cut time and again. 'Offering' to conduct an experiment during these types of experiences by means of sexually stimulating a part of her genitalia seems tasteless at best.

There is a place and time for crude humor, or even just sexual humor, but regarding a serious neuro-disability and the painful hell a person is going through to cope with it is neither that time nor place. If you sincerely feel the need to induce an endorphin effect on a girl while she is undergoing intense pain, perhaps next time you should consider stimulating something other than her genitalia, as that just sounds perverse ... even for the internet.

Re:nerve growth unsuppressed == tumors? (0, Troll)

hesaigo999ca (786966) | more than 4 years ago | (#30407054)

Poor you for thinking I was being humorous about this. I t is a well documented fact that sexual activity , especially any involving direct stimulation of the clitoris in the woman, ( some even the g-spot) tend to release endorphins that help mask the pain, in men, this can also be observed when a man watches a porno, as men are more visual then women (don't know why...) they to tend to release endorphins, being able to even trigger an orgasm just by watching.

I have taken quite a few sex-ed classes in university, especially following the works of such as Masters and Johnson link here [wikipedia.org] .
I take slight insult to your stab at me, however, your ignorance that such a field of expertise exists would let me pardon you for such a blunder.

ps - if you must know, the orgasmic kama sutra practice of finding a constant state of arousal
and even sometimes release, is based on oxygen manipulation as well as constant endorphin agitation. Both of these end up creating the "vibe" needed to get release....however, once the release has been obtained, the state quickly dissipates and would therefor not be practical to actually go to the point of orgasm, merely right before it, if you wanted to try and see what sort of pain killing properties sexual meditation has.

just my 2.5 cents

Re:nerve growth unsuppressed == tumors? (0)

Anonymous Coward | more than 4 years ago | (#30407138)

Actually, for the record, when the sensations back off a bit, my^H^Hthe person mentioned in the beginning of this thread actually does^H^H^H^Hprobably would find both relief and enjoyment. Sexual stimulation releases not only endorphins, but is an excellent psychological distraction.
--orange^H^H^H^H^H^HSomeone other than the author of the GGGP (I swear!)

Re:nerve growth unsuppressed == tumors? (1)

Sinning (1433953) | more than 4 years ago | (#30405668)

Of course, maybe there is a way to let the broken axons regrow like TFA says...

Re:nerve growth unsuppressed == tumors? (2, Interesting)

kripkenstein (913150) | more than 4 years ago | (#30404624)

Tumors form through uncontrolled growth of cells. Axons are the connections between nerve cells that conduct the nerve impulses. There is no cell division proliferation going on here.

That's true, the goal here is to let existing cells regrow their axons, not for cells to multiply - which is what cancer is a bad form of. So this might not directly be relevant to cancer.

However, there are plenty of other ways in which this could turn out to have side effects that make it a bad idea. One basic concern is that there is probably a reason why axon growth is supressed in the central nervous system - after all, the brain is amazingly complicated, and all those connections between brain cells need to be of the right kind. If things start connecting where they shouldn't, badness may occur. So just stopping the suppression might lead to too many connections being made.

But this is all speculation. Bottom line, this sounds like a breakthrough finding by the researchers, and one that will lead to a lot of followup investigation. Kudos to them.

Re:nerve growth unsuppressed == tumors? (1)

Coren22 (1625475) | more than 4 years ago | (#30404662)

Maybe this will lead t the zombie apocalypse! BRAINSSSS!

Re:nerve growth unsuppressed == tumors? (1, Funny)

Anonymous Coward | more than 4 years ago | (#30404944)

However, there are plenty of other ways in which this could turn out to have side effects that make it a bad idea. One basic concern is that there is probably a reason why axon growth is supressed in the central nervous system - after all, the brain is amazingly complicated, and all those connections between brain cells need to be of the right kind. If things start connecting where they shouldn't, badness may occur.

Badness? What do you mean? I can't see any reason train station for thinking that badness blue flower grows on hairy rock under snow go flow sew bow ungh ungh ungh hf h90-39cnba7u3g378fuiai7d7yt5dt5cgb7d6rtcviaskdh jd967d0d867djud9 8d,.... 98tqgo0eb9e

Re:nerve growth unsuppressed == tumors? (1)

CityZen (464761) | more than 4 years ago | (#30405070)

> One basic concern is that there is probably a reason why axon growth is suppressed...

Right - we need to be careful where this is applied, otherwise people might start thinking with other areas of their bodies. Oh wait...

Re:nerve growth unsuppressed == tumors? (1)

citab (1677284) | more than 4 years ago | (#30405238)

I could see one possibility where reconnecting nerves could lead to constant pain and do nothing for any motor functions. In those cases, if the cause of the pain could not be found, the only option would be to cut the newly formed connections.

I think that would fall in the 'Badness' category.

Re:nerve growth unsuppressed == tumors? (2, Insightful)

NiteShaed (315799) | more than 4 years ago | (#30405464)

Or maybe there's just no particularly good reason for them to regrow, meaning, an organism with a badly damaged brain is in dire shape, and unlikely to live long enough to reproduce. Now, that answer sucks from a "But I don't wanna die!" perspective, but evolution doesn't care about that.
Now, humans, being a pretty cheeky bunch, have no problem looking at this as a challenge to be overcome, and due to the fact that we can provide an individual with time and the proper environment to recover from this kind of injury. We can just come along, say "Gee, may have made sense 10,000 years ago when we were swinging from trees, but now why don't we fix this and let Bill recover instead".
Brain injuries like that are rare enough and (without care) fatal enough that we may just have never evolved a repair mechanism, because it didn't grant much of an advantage in survival.

Or maybe it'll make our brains grow uncontrollably until our eyes pop out and our skulls crack open. Could go either way I suppose....

Re:nerve growth unsuppressed == tumors? (1)

Anonymous Hermit (1631203) | more than 4 years ago | (#30406648)

To speculate further, perhaps some individuals have developed synesthesia after minor brain damage triggered a short regeneration cycle? Also, what happens in the brain during a coma? Why do some comatose people wake up years later, while other take only days?

you == cocksucker & teabagger (-1, Troll)

Anonymous Coward | more than 4 years ago | (#30404632)

tumors are for fags...

Re:nerve growth unsuppressed == tumors? (3, Interesting)

La Gris (531858) | more than 4 years ago | (#30404214)

Sure, side effects of nerve growth unsuppression has to be studied. It may have implication in brain function disorders as well as elevated risks of tumors.or any other. By the way, this lead the path to further researches on proteins and other chemical treatments that may just temporarily inhibit that suppressor. Benefits risks ratio for a time restricted unsuppression could offer hope and an acceptable solution for nerve injured.

Re:nerve growth unsuppressed == tumors? (0)

Anonymous Coward | more than 4 years ago | (#30405136)

Even if it does need to be studied, I think the benefits would outweigh any side effects, as long as we know how to control it effectively. But then again, constant severe pain can be just as debilitating as nerve damage, so take that as you will.

Re:nerve growth unsuppressed == tumors? (0)

Anonymous Coward | more than 4 years ago | (#30404228)

It's naaht a tumaah.

Re:nerve growth unsuppressed == tumors? (1)

Captain Splendid (673276) | more than 4 years ago | (#30405108)

GET TOO DA CHOPPAH!

Re:nerve growth unsuppressed == tumors? (5, Insightful)

windsleeper (1158491) | more than 4 years ago | (#30404380)

I would think that given the choice between a) curing oneself from being quadriplegic and increasing one's risk of cancer tremendously or b) staying quadriplegic and cancer-free, I think nearly everyone would choose the cure + cancer-risk route.

Mod parent up. Risk v. reward. (1, Interesting)

svtdragon (917476) | more than 4 years ago | (#30404648)

This. Exactly this.

All medications have side effects, and as consumers of those medications we weigh the potential risks against the potential benefits. In this case, if you're afflicted with a condition that this could cure at the expense of increased risk of (even near-guaranteed) cancer long-term, well, you've got a choice between longevity and quality of life.

Re:nerve growth unsuppressed == tumors? (4, Informative)

bhartman34 (886109) | more than 4 years ago | (#30405102)

As a paraplegic myself (with spina bifida), I'd say that it's not quite a slam dunk that I'd take the cancer risk. It depends on what the increased risk is. Being a paraplegic certainly isn't a roll in the park, but if I had to chose between that and taking a couple of years to die of cancer, I'd take a pass on the cancer. Of course, my willingness to have the treatment would be inversely proportional to that risk, but if the risk of cancer was increased "tremendously", that's not an acceptable risk (to me). I'm not sure how I'd feel about it if I was a quad, though.

Re:nerve growth unsuppressed == tumors? (1)

interkin3tic (1469267) | more than 4 years ago | (#30406870)

I think we should keep in mind that this is a purely hypothetical situation. No one is proposing that we cure paralysis by causing cells to overexpress cancer-causing proteins and just hope for the best! From the abstract:

Together, our results suggest that compromised responsiveness to injury-induced growth factors in mature neurons contributes significantly to regeneration failure. Thus, developing strategies to modulate negative signaling regulators may be an efficient strategy of promoting axon regeneration after CNS injury.

Much more likely is that someone will find a drug, if it hasn't already been found, that can be transiently applied to the broken axons. That wouldn't "increase one's risk of cancer tremendously."

Re:nerve growth unsuppressed == tumors? (1)

oldspewey (1303305) | more than 4 years ago | (#30404446)

On the other hand, as the cancer grows out of control, you just keep getting smarter and smarter.

Re:nerve growth unsuppressed == tumors? (0)

Goblez (928516) | more than 4 years ago | (#30404868)

This. Given that the curve isn't too steep I'll take the increased benefit up to my death.

Re:nerve growth unsuppressed == tumors? (1)

Lemmy Caution (8378) | more than 4 years ago | (#30404896)

So, just before the cancer kill you, you get smart enough to cure it?

Re:nerve growth unsuppressed == tumors? (3, Funny)

2names (531755) | more than 4 years ago | (#30405420)

That would be Phenomenal.

Re:nerve growth unsuppressed == tumors? (1)

Wyatt Earp (1029) | more than 4 years ago | (#30404724)

I had a nerve sheath tumor (non cancerous) which the removal of caused nerve damage, so this all is interesting too me.

Re:nerve growth unsuppressed == tumors? (1)

sexconker (1179573) | more than 4 years ago | (#30404838)

nerve growth unsuppressed == tumors?

Tumors you can feel.

Re:nerve growth unsuppressed == tumors? (1)

Locke2005 (849178) | more than 4 years ago | (#30405792)

I've always held that cancer holds within it the secret to immortality. Aging is caused by cells stopping reproduction over time, in cancer reproduction is turned back on and occurs without any regulation. Viable life walks that razors edge between too much and not enough cell reproduction. Find a way to better control it, and cancer-like turning off of the telomeres could be use to extend life.

In another Zen-like turnabout, if viruses could be modified to make them accurately target only diseased cells, then viruses could be used to cure disease instead of causing it, e.g. a variant of Herpes virus could be used to target cancerous cells (and would remain in the system to deal with a remission should it occur.)

Yes, these are pie-in-the-sky crackpot theories, but the point is that there is no telling what we might make possible by studying these phenomena.

second (-1, Troll)

Anonymous Coward | more than 4 years ago | (#30404008)

second post ftw

Possibilities? (3, Insightful)

quangdog (1002624) | more than 4 years ago | (#30404082)

Of course I did not RTFA, nor am I trained in any sort of medical field - but I imagine that the possibilities that this might present are astounding. Are they hoping to restore mobility and function to people who have had major nerve damage as in the cases of spinal cord injuries? I thought stem cells were all the rage for that..is this a completely different approach?

Also - if we can stimulate the growth of nerve cells to help people, can the same therapy be used for nefarious stuff? (i.e., what happens if you grow too much nerves?)

Re:Possibilities? (3, Funny)

attemptedgoalie (634133) | more than 4 years ago | (#30404256)

(i.e., what happens if you grow too much nerves?)

You have a lot of nerve asking that question. Or at least the person who underwent the treatment would.

Re:Possibilities? (2, Funny)

bmecoli (963615) | more than 4 years ago | (#30404794)

You have a lot of nerve asking that question.

Oh yeah? Well you've got a lot of cranial accessories.

Re:Possibilities? (0)

Anonymous Coward | more than 4 years ago | (#30407176)

You go insane.

Re:Possibilities? (4, Informative)

wizardforce (1005805) | more than 4 years ago | (#30404310)

I thought stem cells were all the rage for that..is this a completely different approach?

Yes. Stem cells form new specialized cells like neurons; this approach on the other hand involves stimulating existing nerve cells to row more axons which are the electrical connections between nerve cells.

Also - if we can stimulate the growth of nerve cells to help people, can the same therapy be used for nefarious stuff? (i.e., what happens if you grow too much nerves?)

Tuberous sclerosis complex [childrenshospital.org] is a disease caused by the growth of too many axons and can manifest in the form of autism and it is also associated with the formation of what are called tubers which are benign tumors in the brain.

Re:Possibilities? (0)

Anonymous Coward | more than 4 years ago | (#30404456)

Also - if we can stimulate the growth of nerve cells to help people, can the same therapy be used for nefarious stuff? (i.e., what happens if you grow too much nerves?)

Enzyte Bob will be very, very, very happy.

Where to go (2, Interesting)

TheMeuge (645043) | more than 4 years ago | (#30404700)

It's one thing to regrow an axon in a petri dish. It's something else to regrow a 1m long axon inside a fully developed human body, and have it innervate the same muscle (for example) that the damaged axon connected to. It's not going to be a trivial challenge. This may have an impact in some traumatic injuries where the bundle can be reconnected before it's scarred shut or resorbed. For chronic conditions, this isn't going to have a direct impact in any near future. An exciting development nonetheless. Will have to follow the primary literature that comes from these authors.

Natural growt? (2, Funny)

gmuslera (3436) | more than 4 years ago | (#30404084)

Made me remember natural parenting [xkcd.com] . Hope it dont applies to this case too.

Re:Natural growt? (0)

Anonymous Coward | more than 4 years ago | (#30405730)

is all you need to get +5 funny posting a link to xkcd? It bears little relation to the story and isn't funny in the slightest.

Re:Natural growt? (1)

jgtg32a (1173373) | more than 4 years ago | (#30407080)

Linking to XKCD is a meme.

You must be new here.

But too much of growth factors can lead to cancer? (1)

mapkinase (958129) | more than 4 years ago | (#30404090)

"when a gene that suppresses natural growth factors is deleted"

That might lead to cancer, as some studies show:

http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=1Ap&q=growth+factor+cancer&aq=f&oq=&aqi=g-c2g-m2 [google.com]

Oh well (1)

Locke2005 (849178) | more than 4 years ago | (#30404224)

Sadly, this news is a little to late for Christopher Reeve [wikipedia.org] ...

Re:Oh well (2, Funny)

Tetsujin (103070) | more than 4 years ago | (#30404248)

Sadly, this news is a little to late for Christopher Reeve [wikipedia.org] ...

Yes, but it'll be ready just in time for Worf's spinal injury...

Re:Oh well (0)

Anonymous Coward | more than 4 years ago | (#30404492)

Well, if we're too late to treat a celebrity's spinal injury then why even try at all?

Re:Oh well (1)

Caged (24585) | more than 4 years ago | (#30404894)

Heh, I had the exact same thought when I was reading the slashdot submission. 5 years too late.

This is something he was working towards for the last years of his life, the ability to regenerate nerve endings and methods of recovering from spinal injuries and campaigned hard against the ban of stem cell research (to no avail).

for the important question: (1)

nimbius (983462) | more than 4 years ago | (#30404232)

will this cause cancer in laboratory rats?

Re:for the important question: (1)

Coren22 (1625475) | more than 4 years ago | (#30404726)

Yes. What doesn't cause cancer in those rats?

Re:for the important question: (2, Funny)

Locke2005 (849178) | more than 4 years ago | (#30405810)

In study after study, scientists have been conclusively proven to cause cancer in laboratory rats.

Excellent (3, Interesting)

jimbobborg (128330) | more than 4 years ago | (#30404234)

Will this work for hearing? Abusing my ears with loud music and gun fire has resulted in some loss of hearing for me. Since I won't read the subscription article, does it say it works for all nerves or just the spinal stuff?

Re:Excellent (4, Informative)

rpresser (610529) | more than 4 years ago | (#30404280)

Hearing loss from loud sounds is more likely due to damage to the hair cells in the cochlea than nerve damage.

Re:Excellent (1)

kcdoodle (754976) | more than 4 years ago | (#30404998)

This might work for nerve deafness.

However, if it is tinnitus (ringing of the ears) you are concerned with, you should check out the work of Dr. Raphael Yoesh at the University of Michigan.

Also read some of the papers written by Geoffery A Manley on the subject.

It seems that birds can regrow the hairs (cilia) in the inner ear, but mammals cannot.

Now if only I could get the hair growing out of my ears to grow in my inner ear, I would be okay. (What?) (What?)

Re:Excellent (2, Interesting)

Lucidus (681639) | more than 4 years ago | (#30405528)

Did you spell those name correctly? Dr. Manley's first name is Geoffrey, and Google doesn't find anything at all for Dr. Yoesh. I'm sure I'm not the only slashdotter who would be interested in more information about tinnitus - my local audiologists are helpless. If you can supply more detailed directions, it would be greatly appreciated.

Re:Excellent (2, Funny)

D Ninja (825055) | more than 4 years ago | (#30405430)

Hearing loss from loud sounds is more likely due to damage to the hair cells in the cochlea than nerve damage.

But, I have all sorts of hair growing out my ears. Why can't I hear!?

Re:Excellent (0)

Anonymous Coward | more than 4 years ago | (#30405488)

Hearing loss from loud sounds is more likely due to damage to the hair cells in the cochlea than nerve damage.

But, I have all sorts of hair growing out my ears. Why can't I hear!?

Insightful and funny. Well done.

Re:Excellent (1)

seven of five (578993) | more than 4 years ago | (#30406852)

But, I have all sorts of hair growing out my ears. Why can't I hear!?

because of all the hair growing out of your ears?

Re:Excellent (1)

Trent Hawkins (1093109) | more than 4 years ago | (#30404956)

I think most ear damage has nothing to do with neurons, unless you have tinnitus and no one is quite sure how to fix that.

Re:Excellent (1)

Fear the Clam (230933) | more than 4 years ago | (#30405396)

Abusing my ears with loud music and gun fire has resulted in some loss of hearing for me.

I want to party with you, guy.

Re:Excellent (0)

Anonymous Coward | more than 4 years ago | (#30405432)

Will this work for hearing? Abusing my ears with loud music and gun fire has resulted in some loss of hearing for me. Since I won't read the subscription article, does it say it works for all nerves or just the spinal stuff?

It's actually not even necessary for non spinal/brain stuff. Peripheral nerves can regenerate their axons without any intervention. Regarding your specific issue

A) Loud sounds damage the cochlear hair fibers that actually transduce the sound into a neural signal, not the neurons or their axons.

B) Sound signals are transmitted via cranial nerve VIII, which is part of the central nervous system although not spinal. So theoretically this new treatment would work on them if they were damaged.

It's been speculated at length within the medical community as to why adult neurons can't regenerate like peripheral, and the best explanation I've seen is that no connection is better than a misconnection. So the real trick won't be getting the axons to regenerate, but rather getting them to regenerate the correct connections.

Re:Excellent (1)

CaseM (746707) | more than 4 years ago | (#30405640)

Sorry I can't be more help, but I found a great podcast [podcastdirectory.com] on ear damage and hearing loss for you.

Re:Excellent (1)

Lanforod (1344011) | more than 4 years ago | (#30406712)

Hmm, I'm doubtful this particular research would apply to your type of hearing loss. I have a profound hearing loss myself as an after effect of having meningitis as a toddler. I'm fairly certain that my hearing loss is direct nerve damage, so I'm very interested in research about regrowing/repairing damaged nerves.

Re:Excellent (1)

Anonymous Hermit (1631203) | more than 4 years ago | (#30406960)

A few years ago, some researchers from my hometown made some significant discoveries regarding regenerating auditory nerves. (I used to hang out with a relative of Helge, so this was very easy for me to google.)

"In 2004 Helge Rask-Andersen and his associates found immature stem cells in the inner ear of adults, a sensational piece of news in the research world. They have also managed to cultivate hearing nerves from stem cells and human tissue from donated cochleae."
http://www.physorg.com/news159637580.html

"Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion.
http://www.ncbi.nlm.nih.gov/pubmed/15855043

Say hi to Algernon for me... (0)

Tetsujin (103070) | more than 4 years ago | (#30404272)

Oh, and ask him how that GRAF shield is coming while you're at it...

Deleted gene? (0)

Anonymous Coward | more than 4 years ago | (#30404284)

why is there a gene to stop regrowth anyway? surely being able to regrow nerves is very beneficial

Re:Deleted gene? (1)

Sinning (1433953) | more than 4 years ago | (#30405902)

Cancer.

wintermute (0)

ShakaUVM (157947) | more than 4 years ago | (#30404506)

When will this treatment become available in the black market neuro shops in China City?

Re:wintermute (2, Funny)

ShakaUVM (157947) | more than 4 years ago | (#30404530)

Stupid fucking autocorrect... Chiba City, you damn android.

emails hacked (0, Funny)

Anonymous Coward | more than 4 years ago | (#30404544)

I saw some emails that said these guys refuse to publish their data in journals that are run by creationists and flat Earth society members. They were also using various biological markers as "proxies" for nerve growth, but when they showed a decline in nerve growth, they were forced to hide the proxy data using their actual measurements of nerve growth. This is totally bogus and these people should be investigated.

I have a stroke... (1)

Rick Richardson (87058) | more than 4 years ago | (#30404586)

"CNS Injury

Injury to the central nervous system (CNS) including the brain and spinal cord are major health problems both nationally and internationally. More than 2 million people in the U.S. suffer traumatic brain injuries annually, well over 500,000 people per year suffer from stroke, and at least 10,000 people per year suffer spinal cord injuries. "

CNS injury is mentioned in the Neuron abstract.

method know as the strangelove solution (1)

gregg (42218) | more than 4 years ago | (#30404604)

"Mein Führer, I can walk!"

Having a spinal cord injury (0)

Anonymous Coward | more than 4 years ago | (#30404674)

Having a spinal injury that has left me a paraplegic I wonder if this is the cure, or is it another "cure" like stem cells.

I can see doctors in India, China, and The Dominican Republic charging huge amounts of money to desperate people looking to live a "normal" life.Where we don't have to piss through a tube or deal with the spasms and constant neuropathic pains.

Re:Having a spinal cord injury (2, Insightful)

couchslug (175151) | more than 4 years ago | (#30404796)

"I can see doctors in India, China, and The Dominican Republic... "

If it's ever perfected, those may be the only affordable places for US citizens to get the treatment.

Re:Having a spinal cord injury (0)

Anonymous Coward | more than 4 years ago | (#30405878)

But the Indian, Chinese, the people of the Dominican Republic won't be able to afford them.

Re:Having a spinal cord injury (0)

Anonymous Coward | more than 4 years ago | (#30406814)

Let those nations start to pony up the kind of money that the west does in R&D and it won't be cheap there anymore either.

Someone needs to pay those kinds of bills. I don't know why, especially on Slashdot, people feel that these cures are as easy to come across. You would think out of all the people on the net who aren't medical professionals that we could be the most understanding about the capital risks involved in getting new products and services from conception to an end user.

Well, there goes another idiom (1)

itwbennett (1594911) | more than 4 years ago | (#30404678)

With this latest scientific advance, complaining that your nerves are shot loses all meaning.

can take a decade to be approved as human therapy (3, Informative)

peter303 (12292) | more than 4 years ago | (#30404716)

First you got to migrate it it to humans.
There there several levels of testing before its even allowed ver much in humans in the US.
Sometimes things will be available abroad before the US if you are lucky. Some spine-damaged patients already try things in Israel and China based on stem cells. but not available in US.

Re:can take a decade to be approved as human thera (1)

geekoid (135745) | more than 4 years ago | (#30405198)

" Some spine-damaged patients already try things in Israel and China based on stem cells."
none of which is working.

Deleted? (1)

RawsonDR (1029682) | more than 4 years ago | (#30404906)

Be smarter to rename it just in case.

Re:Deleted? (1)

Locke2005 (849178) | more than 4 years ago | (#30405834)

Better to move the gene to the recycling bin, to make sure it doesn't accidentally get used.

We've had this for some time (2, Funny)

PPH (736903) | more than 4 years ago | (#30404930)

Its called "sending the kids to summer camp".

Optic nerves? (0)

Anonymous Coward | more than 4 years ago | (#30405020)

How about optic nerves? My dad suffers from glaucoma, which is increased pressure in the eye, slowly damaging the nerves. Result is a slow decrease in vision as the nerves die off...

Can genes be deleted in an adult? (1)

McKeegan (1584871) | more than 4 years ago | (#30405072)

Or does that kind of genetic manipulation need to take place in the zygote? No, I didn't read the subscription link.

Re:Can genes be deleted in an adult? (1)

Gravitron 5000 (1621683) | more than 4 years ago | (#30405358)

Nor did you read the title of this article, it seems.

If this does work... (1)

mpdolan37 (675902) | more than 4 years ago | (#30405230)

Bad news for wheelchair manufacturers.

Now if only... (0)

Hurricane78 (562437) | more than 4 years ago | (#30405298)

...a method of getting doctors (or the average Joe) to even allow themselves to think about actually preventing to fuck up their own nerves in the first place would be discovered. ^^

It’s nice and all that we can fix everything. But in the long run, what is it teaching us, when we can just ride a pony that’s 300 ft tall and covered in chainsaws, and get away without a scratch afterwards?
Even asking a doc what the cause of your disease is, and how to actually prevent it from happening again, will either make him angry, or not be processed at all. They always just prescribe you “moar ignorance” (e.g. in form of painkillers) or fix the problem in your body. Which by definition only works, until you’r jumping on the pony again. If’s like running against a wall, and getting described painkillers for the headache. And it’s really depressing.

Healing means, that it won’t ever come back! And for nearly all diseases, something like that seems to be “not invented here” for all of the whole medical sector. :(

In the long run, we will just learn to never learn. And work hard to do the opposite of natural selection too.
I wonder when that will break that camel’s back...

P.S.: Hmm, how do you split up long nested sentences like that in English? In German, you can write page-long sentences. But I know how to prevent them. In English I always end up with sentences that I myself have already trouble following while I’m writing them! ^^

Re:Now if only... (0)

Anonymous Coward | more than 4 years ago | (#30407198)

Sounds like you have a crappy doctor. Every doctor I am aware of for myself and my friends and family addresses causes and prevention in detail.

That being said, there's not actually anything wrong with humanity developing the ability to ignore a certain kind of injury and thus allowing us to do something we couldn't do before.

Hope this becomes a treatment for ALS (1)

NotSoHeavyD3 (1400425) | more than 4 years ago | (#30405336)

I'm guessing it's far too new to help my mom though. (Who has that. Definitely not a disease to get.)

Male Enhancement!!! (1)

TheRealPacmanJones (1600187) | more than 4 years ago | (#30405604)

Did you realize you have a gene that is preventing you from getting bigger? Not anymore with our patented treatment of gene deletion you can enhance your manhood in no time. Order for yourself or your man now to get rush delivery in time for the best holiday season ever!

Does this help multiple scleroris? (1)

omuls are tasty (1321759) | more than 4 years ago | (#30405700)

Could this somehow be used to help re-grow the axons myelin coating without causing the axons themselves to grow, in order to treat MLS patients?

Serious queston (1)

Wireless Joe (604314) | more than 4 years ago | (#30405724)

I can't RTFA so I'll rely on those smarter than me on here for an educated guess/answer: Could this help my son with Cebral Palsy (resulting from diffuse periventricular leukomalacia), or are stem cells still the best bet? I know it's hard to determine without specifics, but a good guess would help. Thanks.

Re:Serious queston (1)

Wireless Joe (604314) | more than 4 years ago | (#30405804)

And sorry for all the misspellings.

Goes beyond repair? (1)

ACMENEWSLLC (940904) | more than 4 years ago | (#30405992)

So does this go beyond repair? Can the nerves be enhanced? For example, not everyone is built the same...down...there... Not everyone is as sensitive as the other. So could this technology be used to create new nerves?

Just image a new wave of spam!

scalpels for everyone! (0)

Anonymous Coward | more than 4 years ago | (#30406006)

I can finally be a surgeon!

Oops. Nurse, a squirt of neuron-grow right there please.

yet again, (1)

circletimessquare (444983) | more than 4 years ago | (#30406182)

science makes great strides towards achieving the forthcoming zombie apocalypse

Re:yet again, (0)

Anonymous Coward | more than 4 years ago | (#30407008)

Doubtlessly they will have this perfected long before your hack film is ever released.

Question (0)

Anonymous Coward | more than 4 years ago | (#30406376)

Can they regrow damaged liver cells too?

Quick someone tell the guy in the Avatar Movie!!! (1)

jameskojiro (705701) | more than 4 years ago | (#30406838)

That way he can get his spine fixed and I can get my $7.50 back.

Bad journalism at its best... (0)

Anonymous Coward | more than 4 years ago | (#30406872)

This is cold news... If you're really interested in neurology, read real journals not "The Globe and Mail". Check this paper published in 2006: http://www.jneurosci.org/cgi/reprint/26/21/5591.pdf or http://archiv.ethlife.ethz.ch/e/articles/campuslife/bf07querschnittl.html

Load More Comments
Slashdot Account

Need an Account?

Forgot your password?

Don't worry, we never post anything without your permission.

Submission Text Formatting Tips

We support a small subset of HTML, namely these tags:

  • b
  • i
  • p
  • br
  • a
  • ol
  • ul
  • li
  • dl
  • dt
  • dd
  • em
  • strong
  • tt
  • blockquote
  • div
  • quote
  • ecode

"ecode" can be used for code snippets, for example:

<ecode>    while(1) { do_something(); } </ecode>
Create a Slashdot Account

Loading...