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Arctic Bacteria Used To Make Cool Vaccines

kdawson posted more than 4 years ago | from the it's-a-dry-heat dept.

Medicine 74

cremeglace writes "Scientists say they may have discovered a way to develop cool new vaccines — and they mean that literally. By replacing essential genes in a mammalian pathogen with their counterparts from Arctic bacteria, they have created strains that provoke a protective immune response in mice, but that don't spread to the warm parts of the body where they could do serious harm. The team hopes that the method will lead to a new generation of vaccines for major bacterial diseases such as tuberculosis."

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We're all going to die (-1, Offtopic)

Anonymous Coward | more than 4 years ago | (#32893400)

We're all going to die.

Re:We're all going to die (1)

FatdogHaiku (978357) | more than 4 years ago | (#32894426)

We're all going to die.

Well, we're still waiting to hear from Harry Houdini [wikipedia.org] , but I have to admit that the empirical evidence seems to support your claim...

And... (0)

Anonymous Coward | more than 4 years ago | (#32893418)

What could go wrong?

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32893532)

What could possibly go wrong?

FTFY.

Re:And... (3, Insightful)

interkin3tic (1469267) | more than 4 years ago | (#32893784)

What could go wrong?

Jenny McCarthy could open her trap and say it causes autism for one thing.

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32894368)

Who needs Jenny McCarthy when we have the Slashdot crypto-luddite brigade standing reading to yell "WHAT COULD POSSIBLY GO WRONG"?

Re:And... (1)

interkin3tic (1469267) | more than 4 years ago | (#32896780)

It has indeed always struck me as odd that there are so many people here convinced "I am legend" is going to become true, but none of them seem to be concerned about the "Terminator" movies coming true. Is it familiarity breeds comfort, they're more familiar with computers than biology research so they're not as worried, or are they convinced we're doomed to a terminator apocalypse so they're working on their plan to side with the machines and are worried zombies will interfere with that plan?

Re:And... (1)

daid303 (843777) | more than 4 years ago | (#32897296)

Machines need electricity, which we can turn off quite easily right now.

Biological 'stuff' needs food. Which we are.

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32916844)

Until we make solar powered ones with a battery backup to cover night times, or they mod themselves with this capability. What will we do then? Maybe we'll scorch the sky to deprive them of sunlight, then they'll enslave us and use us for power generation along with a form of fusion to generate all the power they'll ever need, and we'll be stuck in The Matrix waiting for Neo to come and rescue us.

Ok, the premise behind The Matrix is a ridiculous, if they had fusion power, they wouldn't need us for power as well, but did you think the sci-fi writers haven't thought of that already, by the time we realise they are a threat we may not have the opportunity to cut their power.

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32895282)

phuk autism

Re:And... (1)

arivanov (12034) | more than 4 years ago | (#32897306)

Your fingers and toes rotting away seems like a good place to start. The temperature there is usually way under 37.

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32897520)

Since there is no such thing as 'vaccination', and vivisection is a fraud, this 'research' is one giant fraud.
Which won't lead to any CURES.

http://www.whale.to/v/hadwen1.html

Re:And... (1)

Thiez (1281866) | more than 4 years ago | (#32899112)

A lot of things have changed in science since 1923. Could you enlighten us with a more recent article, preferably from after the second world war?

Re:And... (0)

Anonymous Coward | more than 4 years ago | (#32918194)

Is the parent really really stupid or really really bad at trolling? If it was supposed to be a troll, please read up on how to troll properly.

Re:And... (1)

ChromeAeonium (1026952) | more than 4 years ago | (#32894610)

What could go wrong? Well, we could forgo a potentially lifesaving new biotech application because laymen don't understand it and like to complain about things they can't be bothered to take the time to understand because they've convinced themselves they know more than the poeple actually doing the science. Bloody hell, sometimes I think Slashdot should change the slogan to 'Stuff for nerds (except biogeeks, they want to kill us all), stuff that matters (except half of what kdawson posts).' It's kind of funny that it sounds like this vaccine is being produced with by transgenic means, which kdawson recently lead an uninformed rant against, including a link to a anti-vax/conspiracy site. Now he posts this. Not very consistent.

Re:And... (1)

ae1294 (1547521) | more than 4 years ago | (#32896564)

What could go wrong?

Zombies...

Trivia Time (4, Interesting)

EdIII (1114411) | more than 4 years ago | (#32893454)

but that don't spread to the warm parts of the body where they could do serious harm.

Interesting bit of trivia.... the human testicles are designed to allow the production of baby gravy (technical term.. look it up) at colder temperatures.

So according to this article the warmer parts of my body (spleen, lungs) will be spared, but my little soldiers will have to bear the brunt of the attack.

Awesome. Idea.

Re:Trivia Time (3, Funny)

Anonymous Coward | more than 4 years ago | (#32893516)

but that don't spread to the warm parts of the body where they could do serious harm.

Interesting bit of trivia.... the human testicles are designed to allow the production of baby gravy (technical term.. look it up) at colder temperatures.

Oh, I get it... You saw a kdawson article and the first thing you thought of was junk.

Re:Trivia Time (1)

Turnpike Lad (1006707) | more than 4 years ago | (#32893610)

I imagine if that got to be a problem, you could just take a really hot bath for a few hours... bring the extremities of your body up over 98.6 and you're cured.

A Delta T Of Epsilon (1)

nunojsilva (1019800) | more than 4 years ago | (#32893898)

But that way your normally warmer parts would be actually at the same temperature as your outer parts. Wouldn't then the vaccine get spread along all of your body?

Anyway, a vaccine that might screw genitalia. That's a choice between the joy of being father (again, for some), or living longer. I wonder if the secondary effects will be that bad, maybe it's no worse than a soft kick.

Re:A Delta T Of Epsilon (1)

Turnpike Lad (1006707) | more than 4 years ago | (#32894644)

But that way your normally warmer parts would be actually at the same temperature as your outer parts. Wouldn't then the vaccine get spread along all of your body?

Well, I guess it depends on whether the engineered bacteria simply tends to avoid high temperatures, or is actually killed by high temperatures.

Re:A Delta T Of Epsilon (1)

nunojsilva (1019800) | more than 4 years ago | (#32901154)

If it is killed at 37C, then any second effect could be avoided by warming the entire body.

But that will probably avoid the good desirable effect too — if it is killed, then it won't even create the defenses it is supposed to create. (Oh, and warming your body would also be bad for testicles, which defeats the main purpose of warming it.)

Re:Trivia Time (1)

Ethanol-fueled (1125189) | more than 4 years ago | (#32894592)

Most nerds have a more targetted, efficient method of keeping their nuts hot:

Laptop computers.

Also, nerds are averse to bathing.

Re:Trivia Time (-1, Flamebait)

Anonymous Coward | more than 4 years ago | (#32893656)

the human testicles are designed to allow....

Dude you can't drop a D-bomp on /. like that. This is the land dogma. Prepare to be hate modded for the next several weeks.

Re:Trivia Time (0)

Anonymous Coward | more than 4 years ago | (#32893676)

baby gravy is slang... weirdo.

Re:Trivia Time (1)

dkleinsc (563838) | more than 4 years ago | (#32893678)

Interesting bit of trivia.... the human testicles are designed to allow the production of baby gravy (technical term.. look it up) at colder temperatures.

Why do you think a very easily damaged body part is right out on the edge of the body completely unprotected by bone or even muscle (bearing in mind that evolution doesn't select for comedic value)?

Re:Trivia Time (4, Funny)

GameMaster (148118) | more than 4 years ago | (#32893882)

"bearing in mind that evolution doesn't select for comedic value"

One look at the duck billed platypus will tell you that's a damn lie.

Re:Trivia Time (0, Troll)

sortius_nod (1080919) | more than 4 years ago | (#32894034)

No such thing as a "duck billed platypus"... there are Platypus though.

Re:Trivia Time (0)

Anonymous Coward | more than 4 years ago | (#32894436)

Are we not allowed to use adjectives anymore?

Re:Trivia Time (1)

commodoresloat (172735) | more than 4 years ago | (#32894520)

The scientific name of the platypus literally means "bill of a duck," fwiw. In any case, maybe you can find a duck billed platypus swimming in the wine dark sea?

Re:Trivia Time (1)

Securityemo (1407943) | more than 4 years ago | (#32894570)

"The wine dark sea", now that's actually a very beautiful name.

Re:Trivia Time (1)

Jason Levine (196982) | more than 4 years ago | (#32907588)

A platypus might look funny, but they make great secret agents. Just ask Dr. Doofenshmirtz.

Re:Trivia Time (1)

GameMaster (148118) | more than 4 years ago | (#32914228)

I don't think "great" is the word he'd use. Besides, would you really take the "expert opinion" of a guy who's been defeated by a potted plant.

Re:Trivia Time (1)

mister_playboy (1474163) | more than 4 years ago | (#32893992)

Why do you think a very easily damaged body part is right out on the edge of the body completely unprotected by bone or even muscle (bearing in mind that evolution doesn't select for comedic value)?

They are where they are for exactly the reason the GP stated... to allow them to be thermally regulated separately from the rest of the body. Ever notice how they can change position? They extend further away to cool down and draw nearer to the body to warm up.

Your sac shrivels in a pool because your balls are trying to stay warm!

Re:Trivia Time (1)

Monkeedude1212 (1560403) | more than 4 years ago | (#32894028)

Ever notice how they can change position?

Yeah, you know I always wondered why the left one liked being on top.

Re:Trivia Time (1)

dkleinsc (563838) | more than 4 years ago | (#32894416)

Err, that was a rhetorical question, just in case it wasn't clear.

Re:Trivia Time (0)

Anonymous Coward | more than 4 years ago | (#32893724)

So what your saying is that your testicles are cold? You should probably see a doctor about that.

Re:Trivia Time (1)

fuzzyfuzzyfungus (1223518) | more than 4 years ago | (#32893896)

Obviously, this research is just part of the satanic one-world-government's evil population control agenda... Developed weaponized testicle gangrene, to be spread via chemtrail by the UN's black helicopters and Area 51 UFOs reverse engineered from Grey alien technology purchased through a blood-pact involving Christian fetuses illicitly harvested by planned parenthood.

What could be more logical?

(Unfortunately, the loonier grade of anti-vaxer will probably be claiming something approximately that sensible over in the pits of squalor that are NaturalNews and Whale.to. If we are super lucky, it will mutate into a rumor loony enough to, say, interfere with the eradication of polio [msn.com] ...)

Re:Trivia Time (1)

Lord_of_the_nerf (895604) | more than 4 years ago | (#32893978)

.... the human testicles are designed to allow the production of baby gravy (technical term.. look it up) at colder temperatures.

Unfortunately (for anyone who has experienced shrinkage) the human penis is incapable of spreading baby gravy at colder temperatures.

Dude... ever hear of the Inuit? (3, Insightful)

way2trivial (601132) | more than 4 years ago | (#32894208)

total population 150,000
http://en.wikipedia.org/wiki/Inuit [wikipedia.org]

Re:Dude... ever hear of the Inuit? (4, Funny)

supachupa (823309) | more than 4 years ago | (#32895766)

total population 150,000 http://en.wikipedia.org/wiki/Inuit [wikipedia.org]

Yeah. don't they make Quicken?

Re:Trivia Time (0, Redundant)

lawpoop (604919) | more than 4 years ago | (#32894260)

(technical term.. look it up)

Um... yeah. The first page of results are links to slang dictionaries, band names, Q&A sites that cater to undereducated people, and pages of that ilk. I'm gonna call BS on this.

Re:Trivia Time (0)

Anonymous Coward | more than 4 years ago | (#32894410)

Trivia indeed, because everyone already fucking knows this. Don't present it like it's some rare knowledge.

Re:Trivia Time (1)

HTRednek (793937) | more than 4 years ago | (#32896740)

So according to this article the warmer parts of my body (spleen, lungs) will be spared, but my little soldiers will have to bear the brunt of the attack.

Awesome. Idea.

Oh come on now... You read /. Its not like your little soldiers have anything better to do...

Cool (1)

jellomizer (103300) | more than 4 years ago | (#32893476)

One word...

Cool

There are already TB vaccines (2, Informative)

h4rr4r (612664) | more than 4 years ago | (#32893490)

There are already TB vaccines, I have the scar to prove it.

http://en.wikipedia.org/wiki/Bacillus_Calmette-Gu [wikipedia.org] érin

Re:There are already TB vaccines (3, Informative)

Cyberax (705495) | more than 4 years ago | (#32893624)

Unfortunately, as vaccines go BCG is on the 'very ineffective' side of the spectrum. It's better than nothing, but just barely.

Re:There are already TB vaccines (0)

Anonymous Coward | more than 4 years ago | (#32897374)

It seems per the WP link to work fairly well (60-80% efficacy, comparable to 95% efficacy seen in some modern vaccines) in the UK and less well elsewhere. This is convenient for the UK (and explains why I'd never heard it called "very ineffective" since I live there) but makes it of dubious value elsewhere.

It would be nice if we were sure why that is (the most obvious test was tried, people with non-British ethnic backgrounds but living their whole lives in the UK still see 60-80% efficacy)

Re:There are already TB vaccines (0)

Anonymous Coward | more than 4 years ago | (#32910474)

It's more complex than that... TB vaccine does not create a herd immunity and TB bacterium is _everywhere_. All BCG can do is to reduce chances of active tuberculosis, it can't stop TB epidemy if it happens.

Better than nothing, sure. But other vaccines can completely stop epidemics.

Ouch (1)

Monkeedude1212 (1560403) | more than 4 years ago | (#32893570)

You know, that pun was good until you beat me over the head with it.

Re:Ouch (1, Troll)

commodoresloat (172735) | more than 4 years ago | (#32894102)

Oh, chill out, man. I think this is pretty damn cool; it's a great way for these scientists to ice their place in history. Things have been moving at a glacial pace in the field until now; I bet this will send shivers down the spines of some of their peers. These scientists are sure to drink a few frosty ones to celebrate before running home to make love to their frigid spouses!

Perfect... (1)

hyades1 (1149581) | more than 4 years ago | (#32893592)

Just in time for Global Warming.

Yeah, yeah, yeah.... (1)

AnonymousClown (1788472) | more than 4 years ago | (#32893622)

" Arctic Bacteria Used To Make Cool Vaccines"

And Tropical vaccines are the next hot thing.

Gotcha.

Re:Yeah, yeah, yeah.... (0)

Anonymous Coward | more than 4 years ago | (#32893680)

ba-dum-ch!

This is a really bad idea. (1)

mosb1000 (710161) | more than 4 years ago | (#32893658)

This is a really bad idea.

This is a really good idea (1)

interkin3tic (1469267) | more than 4 years ago | (#32896758)

Counterpoint: this is a really good idea.

This has been "point counterpoint slashdot style." After all, justifying one's opinion is not for nerds.

Re:This is a really good idea (1)

mosb1000 (710161) | more than 4 years ago | (#32896870)

Hey, I was at work. I can't just be typin' on slashdot all day long! Gimmie a break.

Adapt and Overcome (1)

abbynormal brain (1637419) | more than 4 years ago | (#32893888)

So-called temperature-sensitive vaccines already exist for a few viruses. An influenza vaccine called FluMist, for instance, consists of a weakened flu virus that can't grow at 37C, the temperature inside the lungs, but that can reproduce in the slightly cooler nose and throat. As it does so, it triggers a protective immune response.

Key Words:
- Virus
- Grow
- Reproduce

Oh and one more they didn't mention ...
- Adapt and
- Overcome

Side-Note:
Unofficial mantra of the Marine's: Improvise, Adapt, and Overcome.
(Tough little suckers huh? ... Yeah. I mean both of them)

I like my testicles... how about you? (1)

Fallen Kell (165468) | more than 4 years ago | (#32893918)

.... I mean, seriously, nothing can go wrong with just having these bacteria in the cooler parts of the body...

Re:I like my testicles... how about you? (0)

Anonymous Coward | more than 4 years ago | (#32894494)

I have no interest whatsoever in your testicles. Sorry.

Re:I like my testicles... how about you? (1)

TheLink (130905) | more than 4 years ago | (#32895578)

I'm more attached to mine.

Some scientists have much to learn... (0)

Anonymous Coward | more than 4 years ago | (#32894268)

A winter at McMurdo station with a DVD of the Thing should put them right.

Rotting zombies... (1)

Securityemo (1407943) | more than 4 years ago | (#32894560)

So, you could make a flesh-eating virus that only made the non-essential (or at least non-instant-death) parts of the body slough off?
"Skiiiiinn... Graaghl!" *shuffle shuffle*

Next up: (1)

Lost Penguin (636359) | more than 4 years ago | (#32895450)

Paging Dr. Neville, Robert Neville please broadcast on all AM frequencies....

scientolo (1)

Mana Mana (16072) | more than 4 years ago | (#32895592)

Wha! No imlegend keyword.

Congratulations. (1)

Cur8or (1220818) | more than 4 years ago | (#32895696)

Pun science has been pushed a little further.

Cold Resistant Zombies (1)

JumperCable (673155) | more than 4 years ago | (#32896036)

Great. So much for heading for the tundra when the zombie outbreak happens. Cold resistant zombies are the last thing we need.

Science is simply (1)

nedlohs (1335013) | more than 4 years ago | (#32896194)

fucking awesome.

Arctic Bacteria Used To Make Cool Vaccines on Tues (0)

Anonymous Coward | more than 4 years ago | (#32897078)

"Arctic Bacteria Used To Make Cool Vaccines".

Why did they stop?

How do they replace the genes? (1)

pinkushun (1467193) | more than 4 years ago | (#32897394)

One at a time, the team swapped out nine so-called essential genes

Even Google can't tell me, I'm curious how this is done. I program code, how does one program DNA?

Re:How do they replace the genes? (1)

Spugglefink (1041680) | more than 4 years ago | (#32900596)

Even Google can't tell me, I'm curious how this is done. I program code, how does one program DNA?

They program it in a combination of D [wikipedia.org] , A+ [wikipedia.org] , and the top secret N language known only to genetic engineers. It's so secret, Wikipedia doesn't even have an article about N [wikipedia.org] yet, but it will shortly after our genetically engineered Arctic bacteria vaccine overlords take over the world. Please allow me to be the first to welcome them.

Re:How do they replace the genes? (1)

pinkushun (1467193) | more than 4 years ago | (#32924008)

lol :-) +1 imaginary mod

M. smegmatis I presume (1)

Nick Number (447026) | more than 4 years ago | (#32900620)

From TFA:

As part of the study, the researchers showed they could make Mycobacterium smegmatis

Do you suppose this would be useful in the treatment of Listeriosis?

story tags (1)

Kvasio (127200) | more than 4 years ago | (#32907502)

where is "whatcouldpossiblygowrong" tag, when you need one?

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