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Scientists Turn Skin Cells Into Beating Heart Muscle

samzenpus posted more than 2 years ago | from the grow-your-own-organs dept.

Medicine 121

An anonymous reader writes "By taking skin cells and turning them into stem cells, a technique that is already well known, researchers at Technion Israel Institute of Technology were able to generate beating heart cells — a medical first. 'We have shown that it's possible to take skin cells from an elderly patient with advanced heart failure and end up with his own beating cells in a laboratory dish that are healthy and young — the equivalent to the stage of his heart cells when he was just born,' Lior Gepstein, study author and professor of medicine said."

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WHAT WHITE PEOPLE ARE HIDING! (-1, Troll)

Anonymous Coward | more than 2 years ago | (#40095293)

The time has come again to address world ignorance, the shadow government, and clandestine operations of the deceitful people who currently think they rule the planet. Caucasians are not fully or normally developed human beings but are only the inbred mutant albinos of their genetic masters—Black Africans. Do you know the real reason white people perform laboratory experiments on white lab rats is because those white lab rats share the same genetic code as they share? They share two common factors—the albino, and the inbreeding factor. Those white rats are bred for their albinism and are deliberately inbred to mimic the genealogy of so-called “Caucasians.” White people perform experiments on white rats to see how experiments potentially go over in the human Caucasoid population. If they want to know how something will impact the normal population, the benchmark used is a normally colored rat. In the human world, if they want to know how something will impact the normal human population, their benchmark is a black human being. Black humans contain the only fully developed genes and genealogy is the benchmark for normalcy. Inbreeding has caused the gene pool of white people to become severely depleted, and whites have far less genetic diversity than their black genetic masters.

White people are far more prone to various genetic defects, malfunctions and disorders. Ever notice why white people have far more tolerance for milk the most lactose tolerant? Since white people reflect sunlight with white skin, they do not synthesize vitamin D like normal people, and this automatically decreases calcium levels in the blood. To compensate, they have to have calcium depleted from their bones, leaving their bones porous and weak and leaving whites susceptible to osteoporosis. Their bodies always need calcium because it is always robbed from their bodies. Normal people, after reaching a certain age, no longer need milk and should be waned off of it. In the wild, when was the last time you saw a full grown animal still suckling its mother? Actually, black people should not drink milk. They can get all of the Vitamin D they need from sunshine. Caucasians need supplements to help them make up for the Vitamin D deficiency. This is why most people who are lactose intolerant are black people and why white people are not only the most lactose tolerant, but needy. In the supermarket, notice how many products have calcium added in them from orange juice and other fruit juices to breakfast cereal? All that extra calcium fortification is to aid whites in their inability to maintain healthy vitamin D levels in their bodies because of the genetic defect. This is the governments way of “leveling the playing field” if you will.

Why is there so much secrecy at various military bases and archaeological digs? This is really where the shadow government arrives. White people are hiding the fact that today’s technology is nothing more than recycled ancient technology from civilizations long ago. The secret aircraft they are manufacturing at area 51 out in the western United States are only reversed engineered aircraft from ancient aircraft excavated from archaeological digs. The shadow government is rediscovering and recycling this technology and taking credit for it as though they are the originators, when in fact they are not. It is all a part of the white “supremacy” proliferation at the expense of their genetic masters Black Africans. The way the system works is as follows: Various archaeologists, Egyptologists etc. are dispatched to various archaeological digs to excavate ultra classified ancient artifacts or anomalies that must remain hidden and unknown to the vast majority of the world. These artifacts and anomalies are sent to various laboratories and universities who are given government funding to “figure out how these things work and recreate or reverse engineer them” in a way that implies that so called modern white men are the originators and progenitors of this technology, and all traces of any ancient ties are clearly swept away and eradicated from the equation. The more universities contribute to this task, the more they are rewarded with bogus prestigious ranks by US News and World Report and THES the times of London. It works similarly for corporate giants like AT&T, IBM etc. MIT’s Lincoln Laboratories is a main culprit in reverse engineering these artifacts and anomalies. This is why they are so highly revered and respected. How many black archaeologists or Egyptologists do you know? Black people are diverted from certain areas of expertise or professions and for good reason. The shadow government does not want black people to go into areas of Archaeology, Egyptology, Biochemistry, etc. in large numbers because expertise in these fields will show black people just how fraudulent the world’s current paradigm really is.

The seat of a shadow government can be located London, England. Many people believe the United States of America received independence from England after signing of the Declaration of Independence. The truth of the matter is, not only was the Declaration of Independence a farce, we are still a British colony like many other parts of the world. Everything that goes on in the United States from the economy to fashion is dictated by the British. It always has been. Most people don’t realize this, but it is the truth. Warren Buffet and Bill Gates are not the richest men in the world, the Rockefellers and the Rothschild’s are. They are literally trillionaires. The Rothschild’s are worth an estimated 100 trillion dollars or more. They are the higher ups in the Illuminati who are the main ones controlling world affairs. The Boule is the people like Bill Gates, Warren Buffet and others who take the heat for the super powerful men behind the scenes. The world is not really what it seems. There is more or less a dichotomy of reality. There is the official reality that most people think they know, and then there is the truth. The shadow government works feverishly to keep that truth hidden from plain view. Remember the “Secret Covenant” that I discussed in a past essay. Certain truths just can’t get out in the open. The main ones: That white people are black people’s inbred mutant albino offspring, that modern technology was actually originated by ancient black super civilization from long ago, and that many of the things that is wrong with the world are completely white people’s fault, from out of whack weather situations to various disease outbreaks, to even this economic crisis we are going through as we approach the next decade beginning in 2010. All of these things are at the hands of the shadow government. Never trust white people. The prime directive of those mutants is to deceive the world and maintain their inferior genetic strain at all costs. That is the real reason for stem cell research and cloning. As I have pointed out, white people cannot reproduce themselves efficiently like normal black people so they need extra help like cloning, stem cell research and surrogate mothers. In many parts of the world, white people cannot carry their unborn children to full term because they are victimized by photolysis. Solar radiation depleting their foliate levels keeping cell replication difficult or impossible. So what do they do? Find black women or Indian women or other women of color to carry their children to term for them. White people are unnatural genetic defects and freaks of nature who cannot function as normal human beings. They should not even exist within the context that we understand them and they certainly should not be ruling over their black genetic parents. Once you understand these key concepts, you are well on your way to understanding what white people are hiding from you, that you should know.

Re:WHAT WHITE PEOPLE ARE HIDING! (1, Funny)

Nidi62 (1525137) | more than 2 years ago | (#40095315)

Can we bring back the my clean pc guy? At least his spam posts are shorter and more entertaining to read.

Re:WHAT WHITE PEOPLE ARE HIDING! (1)

Samantha Wright (1324923) | more than 2 years ago | (#40095785)

I weep at the thought of how much server disk space goes into storing these half-hearted spam messages. Slashdot clearly needs some sort of r9k solution.

Re:WHAT WHITE PEOPLE ARE HIDING! (3, Funny)

slashchuck (617840) | more than 2 years ago | (#40095931)

Slashdot should reduce the font size of the Troll/Flamebait postings. It will cut down on the disk space used.

Re:WHAT WHITE PEOPLE ARE HIDING! (1)

Genda (560240) | more than 2 years ago | (#40096425)

Do they make a 0.0001 point font? Screw the disk space, He's wasting my life space... I want that post covered by a single period.

Re:WHAT WHITE PEOPLE ARE HIDING! (0)

Anonymous Coward | more than 2 years ago | (#40099183)

Someone seriously found this funny? /dismayed

Re:WHAT WHITE PEOPLE ARE HIDING! (1)

geekoid (135745) | more than 2 years ago | (#40095449)

Damn it, he found us out. ok White ISP guy, give use his address so he can have a heart attack tonight.

" white people cannot reproduce themselves efficiently like normal black people"
there is no subspecies of human being.

Re:WHAT WHITE PEOPLE ARE HIDING! (0)

Anonymous Coward | more than 2 years ago | (#40095719)

All the joy of riding a public bus with a crazy on board, right here in a post on slashdot...

Re:WHAT WHITE PEOPLE ARE HIDING! (0)

Anonymous Coward | more than 2 years ago | (#40097113)

Yea, we allready know this! London rules the world, all the royals control the major corporations, royals killed Kennedy, white are killing all the africans in africa, the royals plan on inslaving every one, yet its to late too do any thing about it know, so just eat the poison and enjoy.

Re:WHAT WHITE PEOPLE ARE HIDING! (0)

Anonymous Coward | more than 2 years ago | (#40099145)

If being enslaved by the Royals means I get to bang Pippa, then I for one welcome our Royal overlords. I wonder if she likes hot grits?

Re:WHAT WHITE PEOPLE ARE HIDING! (0)

Anonymous Coward | more than 2 years ago | (#40099109)

tl;dr.

More of this, please (1)

geekoid (135745) | more than 2 years ago | (#40095297)

Hurry up already. I want to see easily replaceable hearts in MY life time...also ever other organ.
IN fact, just full body clone replacements and transplant my head.
.

Re:More of this, please (2)

WillDraven (760005) | more than 2 years ago | (#40095397)

I'll be happy as long as modern medicine can keep me alive until we perfect mind uploading. Sometimes I get really sick of being a bag of meat.

Re:More of this, please (1, Interesting)

geekoid (135745) | more than 2 years ago | (#40095425)

Great, so there is a copy of you on the internet, then what? is the meat you going to go kill itself? Or you can all create one big conglomerate of personalities, which would then stagnate.
Pass.

The machine alone is too limiting.

Re:More of this, please (4, Interesting)

WillDraven (760005) | more than 2 years ago | (#40095499)

Personally, I'm hoping that we get back on track with space travel, and then I can upload myself into an interstellar space probe. If nano-tech gets good enough, you could maybe even reconstitute a physical body if you find someplace interesting to land. With an electronic mind, you could alter your perception of time so the boring parts of floating between stars for years would only last a few minutes subjectively.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40095663)

That would make a great movie...

Re:More of this, please (4, Funny)

Adriax (746043) | more than 2 years ago | (#40095841)

The toggle for the host computer's perception speed had better resemble a 386SX-16 turbo button or I wouldn't even bother.

Re:More of this, please (3, Funny)

K. S. Kyosuke (729550) | more than 2 years ago | (#40097897)

The toggle for the host computer's perception speed had better resemble a 386SX-16 turbo button or I wouldn't even bother.

Yes, but if you're already inside the computer, how do you press the button?

Re:More of this, please (1)

RivenAleem (1590553) | more than 2 years ago | (#40098659)

OMG! Mind-rebooted.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40097095)

until you are hit by a magnetic storm or such and your memory is wiped. you'd be just as fragile as all computes are.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40099171)

Given my proclivity for bacon I bet I taste great! I'll upload to the machine consciousness and then make myself a nice BBQ me sandwich. Mmmmm...

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40095445)

So you want to be a bag of silicon instead?

Re:More of this, please (1)

Genda (560240) | more than 2 years ago | (#40096449)

Sadly yes, he wants to be a bag of Silicon, inflating some some nymphet's bust line.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40097397)

Can you get closer to a tit?

Re:More of this, please (2)

jamesh (87723) | more than 2 years ago | (#40095691)

I'll be happy as long as modern medicine can keep me alive until we perfect mind uploading. Sometimes I get really sick of being a bag of meat.

What if someone illegally downloads you? That could really hurt!

Re:More of this, please (1)

Nidi62 (1525137) | more than 2 years ago | (#40095807)

What if someone illegally downloads you? That could really hurt!

Yeah, every time Lucy Liu got illegally downloaded her head got shocked. Certainly looked painful.

Re:More of this, please (1)

barv (1382797) | more than 2 years ago | (#40097197)

Hurry up already!

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40097719)

Even if you could upload your mind, you probably would still be a bag of meat. After all, it's only a copy.

Re:More of this, please (2)

kermidge (2221646) | more than 2 years ago | (#40095517)

Amen. If they could use these cells to repair heart and vessels, I'd be second in line. And if this technique could be adapted to various eye parts, sign me up. Although my curiosity exceeds optimism I'd like to stick around a bit to see what happens.

That's what YOU say! (1)

For a Free Internet (1594621) | more than 2 years ago | (#40096011)

But because of the incident with the Teal group, nobody in their right mind will believe you, you pathetic fraud. Eat your popcorne and shut up! BAH

Re:More of this, please (2)

blackest_k (761565) | more than 2 years ago | (#40098371)

In a heart attack, the heart muscle is deprived of oxygen and begins to die, and later becomes scar tissue, which leaves your heart with a reduced capacity to pump blood round your body.

This could potentially be the chance to regenerate the Heart Muscle repairing the damage.

The 50% rate after an initial heart attack is around 6 to 8 years (30% die from an initial heart attack) with a 25% chance of death in the first year. Quite depressing, although after year 1 its 3% compared to 1.5% for normal folk. Obviously the greater the damage caused by the blockage the more likely it is to kill you sooner rather than later. In the case of severe damage maybe stem cells might be an effective treatment and well worth the risk of cancer later in life.

It is worth remembering that it takes 20 - 30 minutes before the heart muscle begins to die so if you think you may be having a heart attack go for treatment and proper diagnosis fast. Leaving it for a few hours might not kill you but it will reduce your long term chances and quality of life.

For me it just felt like i couldn't catch my breath, for a friend of mine his pulse was 43 I forget his BP but 43 is very low for a fat old bloke, I got him to a Dr against his wishes (he had an appointment 3 hours later he wanted to wait for that) and he now has a triple bypass and a pacemaker. 2 years on he is still ok but waiting would have killed him.

My health is pretty good because i had minimal damage i have 2 stents fitted which work really well and a noticeable increase in energy levels immediately after. The stents are fitted from your groin and 3 days later i was out of hospital. A heart attack isn't necessarily painful some people will feel a pain in the left arm or pressure on their chest sometimes it might feel like indigestion or heart burn.

             

Re:More of this, please (4, Funny)

Spiked_Three (626260) | more than 2 years ago | (#40095577)

My head is ugly. I want all new please.

Just the left side (1)

Dareth (47614) | more than 2 years ago | (#40099227)

I just want the left side of my body replaced with technology. Then I would finally be "All Right".

Re:More of this, please (1, Interesting)

geekmux (1040042) | more than 2 years ago | (#40095957)

Hurry up already. I want to see easily replaceable hearts in MY life time...also ever other organ. IN fact, just full body clone replacements and transplant my head. .

Sure, no problem! I'm certain we'll have all that technology and more within the next 30 - 50 years.

Oh, I'm sorry, did you expect insurance to pay for ANY of that shit? Ha! Good luck. Might as well forget that retirement villa, you're gonna blow your 401k just trying to save your ticker, because even at that age, insurance will still be just as corrupt, and the medical industrial complex will continue its obscenely profitable model of treating instead of curing.

Re:More of this, please (1)

harley78 (746436) | more than 2 years ago | (#40097675)

If he got what he wanted that wouldn't be a problem as he'd probably have another 50 some odd years. BTW, some people can pay for this shit without insurance. We don't all live paycheck to paycheck. Other countries besides the USA have decent prices also.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40098759)

I live in the UK but thought the 401k was for retirement. If organs are being replaced and you are living longer, then there is no retirement, there is no career advancement, there will have to be wholesale sterilisation to prevent a population explosion, the rich will own private armies to prevent any of their wealth from being dissolved and the poor will be forgotten.

Re:More of this, please (3, Funny)

Lynchenstein (559620) | more than 2 years ago | (#40096909)

If they could clone and replace "certain" organs with, oh, say, perhaps, LARGER versions, they could pay for all future research with the proceeds of this technique.

Of course *I* don't need this, but I'm sure *others* might...

Re:More of this, please (2)

harley78 (746436) | more than 2 years ago | (#40097693)

Oh, I get it! You mean the Liver!

Re:More of this, please (1)

interkin3tic (1469267) | more than 2 years ago | (#40097365)

Wrong forum: write to your legislators that you want the NIH to receive more funding for research.

Re:More of this, please (0)

Anonymous Coward | more than 2 years ago | (#40097413)

My wife had Kidney failure after having our first ( and only child) about 13 years ago. Her mother donated a kidney to her after 4 year on Dyalysis. She pops many pills each day to keep her from rejecting it and those pills will eventually kill her.
The donated kidney will hopefully last abotu 20- 25 years but then what? She will be 50 years old and then go on another waiting list?

This sort of technology will save many lives and I am waiting fo rthe medical advances to create a NEW kidney that will not require so many drugs to manage!

Re:More of this, please (1)

thoughtsatthemoment (1687848) | more than 2 years ago | (#40098019)

I think there is one part in your brain that you don't want to replace. If you do, you'd effectively have committed suicide. (hint the most import part of the computer is ...).

Re:More of this, please (1)

thoughtsatthemoment (1687848) | more than 2 years ago | (#40098027)

typo: import -> important

Re:More of this, please (1)

virgnarus (1949790) | more than 2 years ago | (#40099267)

This [wikipedia.org] should be effective at accomplishing that.

So it only goes to follow... (1)

l0ungeb0y (442022) | more than 2 years ago | (#40095305)

That next week they'll announce the ability to regenerate an entire body from skin cells in 10 to 20 years, depending on funding of course.
Lots and lots of funding -- preferably in the form of grants and endowments.

Re:So it only goes to follow... (1)

Anonymous Coward | more than 2 years ago | (#40095575)

Speaking of endowments - penis enlargement anyone?

Re:So it only goes to follow... (1)

Genda (560240) | more than 2 years ago | (#40096689)

This is going to be stupid... a generation of Alpha Males, rooted to the spot by their 400 lb, 6 foot appendages... Just because you have the money and science makes it possible doesn't mean you should do it!

Re:So it only goes to follow... (1)

Anonymous Coward | more than 2 years ago | (#40097895)

Rooted to the spot? You forgot about wheelbarrows.

Re:So it only goes to follow... (3, Funny)

tomhuxley (951364) | more than 2 years ago | (#40098681)

Finally a real use for Segways!

Would they still need big trucks then? (1)

Dareth (47614) | more than 2 years ago | (#40099237)

Would they still need big trucks then? You know, to compensate.

A question for the bio geeks.. (4, Interesting)

wbr1 (2538558) | more than 2 years ago | (#40095321)

By taking skin cells and turning them into stem cells as the precursor to other cell lines that match the patients genetic makeup. are you increasing the chances of cancer?
In my certainly uninformed view, skin cells are exposed to more radiation, thus more likely to have replication errors in their DNA, then adding the stress of modifying the cell to another form, I wonder what that does to it from a replication standpoint. It is nice to have fresh heat muscle I am sure, but to suddenly find yourself with melanoma in the heart would be a bummer.

Re:A question for the bio geeks.. (3, Informative)

dgatwood (11270) | more than 2 years ago | (#40095361)

Unless you wear string bikinis, most folks have plenty of skin that never sees the sun. That said, I would expect a cheek swab (the mouth variety) to be a more common way to get those cells.

Re:A question for the bio geeks.. (3, Funny)

ThatsNotPudding (1045640) | more than 2 years ago | (#40098437)

Unless you wear string bikinis, most folks have plenty of skin that never sees the sun.

Taint: is there nothing it can't do?

Re:A question for the bio geeks.. (0)

Anonymous Coward | more than 2 years ago | (#40095363)

you could take skin cells from where the sun doesn't shine.

Re:A question for the bio geeks.. (4, Funny)

cvtan (752695) | more than 2 years ago | (#40095393)

That means you could literally make a politician out of a horses ass!

Re:A question for the bio geeks.. (5, Insightful)

RabidReindeer (2625839) | more than 2 years ago | (#40095495)

That means you could literally make a politician out of a horses ass!

That's just a circular exercise. You end up with the same thing you started with.

Re:A question for the bio geeks.. (0)

Anonymous Coward | more than 2 years ago | (#40095411)

As a completely true and not funny story, I had a friend who got skin cancer there. So the sun doesn't have to directly shine somewhere for you to get cancer there. o.0

Re:A question for the bio geeks.. (1)

jamesh (87723) | more than 2 years ago | (#40095699)

you could take skin cells from where the sun doesn't shine.

For the stereotypical slashdotter, that's any part of the body ;)

Re:A question for the bio geeks.. (5, Informative)

Kurofuneparry (1360993) | more than 2 years ago | (#40095431)

Biochemist medical student here. Propagating genetic errors is certainly a concern here, but the same concerns exist for genetic transfer in breeding generally. While skin cell are exposed to more radiation, the cells preferred for sampling here are typically from buccal (mouth) sources or are relatively deeper than the layers where most melanoma form.
Honestly, the more prime concerns are with imperfect "stemming" or imperfect conversion to heart cells.
Then again ... I'm and idiot ....

Re:A question for the bio geeks.. (4, Informative)

ColdWetDog (752185) | more than 2 years ago | (#40095623)

At any rate, this is early on in the program. Nobody is making new hearts just yet. Cancer certainly is an issue but only one of many potential problems.

The abstract [oxfordjournals.org] in case anybody cares. The real article is behind the usual paywall. Grrr.

Re:A question for the bio geeks.. (1)

ChrisMaple (607946) | more than 2 years ago | (#40096309)

So the place of choice is where the sun doesn't shine?

Re:A question for the bio geeks.. (1)

Sulphur (1548251) | more than 2 years ago | (#40096375)

So the place of choice is where the sun doesn't shine?

Are you ignoring the advances in fiber optics?

Re:A question for the bio geeks.. (0)

Anonymous Coward | more than 2 years ago | (#40097215)

Then again ... I'm and idiot ....

At least you didn't get that part wrong!

Re:A question for the bio geeks.. (3, Interesting)

Biotech_is_Godzilla (2634385) | more than 2 years ago | (#40098105)

I'd agree about the imperfect stemming/heart cell conversion thing, but not with this:

Propagating genetic errors is certainly a concern here, but the same concerns exist for genetic transfer in breeding generally.

They're not exactly the same concerns. 'Normal' somatic cells, cells of the body which aren't stem cells, have a much higher capacity for surviving with DNA damage in their genomes than stem cells. This is because they have stopped growing & proliferating and hence stopped replicating their DNA, and a major method by which DNA damage is detected in the cell is by "testing whether DNA replication can occur". When DNA replication fails or is particularly difficult there's a good chance a proliferating cell (i.e. stem cells) will activate DNA damage checkpoints and die or senesce (stop growing permanently).

The methods used to make "stemmed" cells (induced pluripotent stem cells) usually involve introducing some oncogenes which ultimately mess up activation of the DNA damage checkpoints. Also, the genes that are introduced during the process of "stemming" are randomly scattered into the genome, potentially inserting into and knocking out the cell's tumour suppressor genes, so cells which may already be in a DNA-damaged state can be further damaged while being deliberately converted to a highly proliferating state. The process selects for cells which can proliferate even when damaged, which is not ideal as far as preventing cancer is concerned. New methods, using drugs and not the introduction of oncogenes, have been produced, but I don't think they're commonly used yet (correct me if I'm wrong, someone).

I don't pretend to understand what's unique about how DNA damage is dealt with during sex to prevent mutations being propagated to the next generation. I'm not sure that much work has been done on it, but germline sperm and egg-producing cells are stem cells, so damage isn't likely to be that well tolerated in them, and if sperm is very damaged it's likely to be inviable and won't lead to conception. I had to go off and research this to have something to say about it, during which I found the following tidbit: having sex/ spanking off once a day gets rid of damaged sperm and seems to be a way of maintaining a bloke's fertility in tip-top condition [sciencedaily.com] . So blokes are probably biologically programmed to masturbate, in case you needed an excuse!

Re:A question for the bio geeks.. (3, Informative)

Kurofuneparry (1360993) | more than 2 years ago | (#40098917)

While you are correct about many of the concerns from the stemming process, I was mainly talking about somatic mutations (like those caused by gamma radiation for example). The statement I made previously about these somatic mutations propagating no more in stemming than in breeding is still true. Also, the proto-oncogene concern is one that current research is already working toward limiting.
My main concern with your statement is the argument that stem cells are MORE susceptible to random mutation than somatic cells. This is simply false. You argued that decreased activity is a protective attribute than for stem cells. In fact, most stem cells in the human body are LESS active than somatic cells as somatic cells do the work and (monopotent) stem cells like osteoprogenitor cells are mainly there to replenish and preserve genetic information. It's a biological axiom that sex cells (sperm and ova) have the highest importance in preserving genetic integrity and that's what we see experimentally: the sex cells have BETTER preservation of information, not worse.
.... Then again ..... I'm an idiot ....

Re:A question for the bio geeks.. (5, Insightful)

geekoid (135745) | more than 2 years ago | (#40095469)

No.

If it were true, so what? You need a heart replacement or you will die, soon. If the procedure might give you cancer in 20 years, isn't that still a good trade?

Re:A question for the bio geeks.. (0)

Anonymous Coward | more than 2 years ago | (#40097759)

By taking skin cells and turning them into stem cells as the precursor to other cell lines that match the patients genetic makeup. are you increasing the chances of cancer?

In my certainly uninformed view, skin cells are exposed to more radiation, thus more likely to have replication errors in their DNA, then adding the stress of modifying the cell to another form, I wonder what that does to it from a replication standpoint. It is nice to have fresh heat muscle I am sure, but to suddenly find yourself with melanoma in the heart would be a bummer.

Lets say your cancer risk increases 10 fold. That would be, maybe 1%. If you have advanced heart failure it is worth the risk.

stem cell researcher here. (0)

Anonymous Coward | more than 2 years ago | (#40099249)

Cancer is actually a concern with any stem-like cells, because they all have telomerase activity, and frequently have active myc or other proto-oncogenes that allow cells to divide indefinitely. (these authors only used Oct, Sox and Klf - most groups also use the oncogene myc to reprogram cells for that exact reason)
However, its actually really hard to get cancer: if you inject one cancer cell into the body (or even up to a few million) you will probably still not get a tumor. Likewise, when you go from stem back to heart cell, the cells slow down their division rate and generally stop acting cancer-like.
Your concern that skin cells from aged patients may be abnormal genetically to start is a minor concern, and can be checked

immortality (3, Interesting)

Anonymous Coward | more than 2 years ago | (#40095339)

every advancement in medicine, and health is another step towards immortality.
Only problem is, you can replace everything in the body except the brain.

generations from now people will be living over 200 years of age, I can see new problems arising.
Over population is a problem and the average lifespan is under 70.

I see a future of hybrid human technology species

Re:immortality (5, Insightful)

Anonymous Coward | more than 2 years ago | (#40095441)

Over population is a problem ...

Overpopulation is not a problem. That is a myth that has been perpetuated since the latter half of the 18th century. Do the math [youtube.com] .

Only problem is, you can replace everything in the body except the brain.

Perhaps even the brain... someday. There's nothing inherently mystical or supernatural about the brain that must make it impossible to transfer knowledge and identity from one to the other. We just don't know how... yet.

I see a future of hybrid human technology species

Without a doubt. I anticipate that it will start becoming a regular occurrence for people to augment their physical and even mental abilities with machines well before the end of this century.

Re:immortality (1)

FrootLoops (1817694) | more than 2 years ago | (#40096655)

Indeed, many humans currently have technology implanted in them. My dad has both an internal cardioverter-defibrillator (a pacemaker that also shocks his heart out of dangerous rhythms) and a ventricular assist device (a battery-powered heart pump). He would be long dead without the shocker, and he would probably be dead without the pump. This likely isn't what you had in mind, but it's something real.

Re:immortality (0)

Anonymous Coward | more than 2 years ago | (#40098129)

"Overpopulation is not a problem. That is a myth that has been perpetuated since the latter half of the 18th century. Do the math."

"Brought to you by.
http://www.overpopulationisamyth.com/ [overpopula...samyth.com] "

"Copyright © 2010â"2011 Population Research Institute. All rights reserved. "

http://pop.org/about/who-we-are-800 [pop.org]

"Our growing, global network of pro-life groups spans over 30 countries."

"pro-life" ....

Re:immortality (1)

Exrio (2646817) | more than 2 years ago | (#40098657)

Mind conservation: THAT'S THE FUCKING PROBLEM. We need new minds - blank brains. Imagine having to live with old and rich people who has the MAFIAA mindset for indefitine time... You know they're the ones who have enough paper in their wallets to pay the bill for life extension treatments the day they're available, and while newer generations may seem fresh now I'm sure they will start presenting similar problems 60 years on. We really should solve the social problems of the world before we start talking about solving the bioligical ones. All this stuff is like throwing hardware at the problem without ever bothering to look at the (sorry state of the) software. Sometimes it infuriates me.

Re:immortality (-1)

Anonymous Coward | more than 2 years ago | (#40097103)

Turning skin cells into heart muscle ---> 5~10 more years to live, nothing else after that
Suicide bombing in the name of allah ---> immediate death but 72 virgins waiting for you in the eternal afterlife

Guess which side has more recruits in their lines...

Re:immortality (1)

interkin3tic (1469267) | more than 2 years ago | (#40097497)

But the current average lifespan is not reflective of future medical breakthroughs. If we make replacement hearts, livers, and kidneys in the next 10 years from induced pluripotent stem cells, that will really boost that number up quite significantly. Possibly it will extend our lives until we learn how to replace neurons with circuitry. Maybe we'll live that long naturally anyway.

The far future is wide open with possibilities, who is to say we can't achieve virtual immortality in our lifetimes? I mean, I'm not betting on it, but ruling it out entirely?

Where's George Bush? (0, Troll)

Anonymous Coward | more than 2 years ago | (#40095427)

We need a republican hero to block this effort!

Re:Where's George Bush? (4, Funny)

Spiked_Three (626260) | more than 2 years ago | (#40095593)

they cloned him as Mitt Romney and he is on the way, patience.

Re:Where's George Bush? (1)

zotz (3951) | more than 2 years ago | (#40098183)

"I don't understand why people who like command line environments don't get punch card machines for the best experience."

~;-)

If you have used both, surely you can at least hazard a guess...

Re:Where's George Bush? (1)

LordLucless (582312) | more than 2 years ago | (#40095601)

I was wondering how long it would take some troll to raise the utterly irrelevant controversy over embryonic stem cells.

Re:Where's George Bush? (0)

Anonymous Coward | more than 2 years ago | (#40095671)

We need a republican hero to block this effort!

How would he block research in Israel is beyond me...

Re:Where's George Bush? (0)

Anonymous Coward | more than 2 years ago | (#40096099)

AC Fail.

More likely a Democrat would because it's doesn't involve fetal stem cells.

Re:Where's George Bush? (1)

Cute and Cuddly (2646619) | more than 2 years ago | (#40097793)

Bush is being protected by PETA. So much making monkey faces, they think he is one!

Re:Where's George Bush? (2)

JOrgePeixoto (853808) | more than 2 years ago | (#40098391)

We need a republican hero to block this effort!

No one opposes research involving stem cells that does not kill human embryos.

By resorting to straw man, you just show you have no real argument.

Ah yes, the human heart... (1)

sootman (158191) | more than 2 years ago | (#40095725)

... also known as "the love muscle." [imdb.com]

Tell the Palestinians..... (-1, Troll)

InspectorGadget1964 (2439148) | more than 2 years ago | (#40095881)

Since Israelis do not have hearts, they are trying to manufacture one. Hopefully they will become human beings one day soon..

Re:Tell the Palestinians..... (-1, Troll)

Anonymous Coward | more than 2 years ago | (#40096145)

Fuck the Palestinians.

Have you done your suicide bombing for the day?

Re:Tell the Palestinians..... (-1, Flamebait)

InspectorGadget1964 (2439148) | more than 2 years ago | (#40096243)

No, I have not done my suicide bombing of the day. I have not behaved as an aggressive uneducated imbecile either (Unlike you). Instead, I have behaved in a polite way, even to people that do not deserve it. Unlike the Israelis, I have not killed women nor children to steal their land and unlike you, I can write proper English without the need to show lack of education nor bad manners using vulgarities and profanity.

The Tin Man rejoices (1)

c4tp (526292) | more than 2 years ago | (#40096241)

The Tin Woodman rejoices

Re:The Tin Man rejoices (0)

Anonymous Coward | more than 2 years ago | (#40099071)

I'm so happy for him! We'll just take a few of his skin cells and... oh crap.

Soon enough? (1)

Shavano (2541114) | more than 2 years ago | (#40096277)

That's really impressive, but is it medically useful in the instance they mention in the summary? If you have advanced heart failure, aren't you in danger of your heart just topping REAL SOON NOW? Can they use the stem cells to repair your heart before you die? It would be more credible to treat people who have had a heart attack and some damage but aren't yet in advanced heart failure.

Re:Soon enough? (1)

Genda (560240) | more than 2 years ago | (#40096731)

In fact, there is recent work described in this months Discover [discovermagazine.com] about using proteins produced by pythons (and no not the language) to renew and strengthen damages hearts.

Re:Soon enough? (1)

Anonymous Coward | more than 2 years ago | (#40096981)

Failure is the danger of a tear in the muscle or a valve. A tear is usually what cascades into death. We've gotten good at patching, but usually that requires heart tissue. From your heart. Whoops. Being able to patch from cadavers lasts not too long (at best, a couple years, at worst it fails immediately on restart). Creating native (genetically matching) and living tissue, you go from potential failure in the forseeable future to potential failure in another area before the patch fails.

Hair cells please (1)

ChrisMaple (607946) | more than 2 years ago | (#40096333)

I'd like not to have to wear a hat to keep my scalp from being sunburned.

Re:Hair cells please (1)

alantus (882150) | more than 2 years ago | (#40097837)

I second that! Is there any research going on to grow hair???
I know being bald is not as bad as having a heart problem, but it is definitely something that people need and would make a lot of money in return.

Clumsy me, broke the bottle (0)

Anonymous Coward | more than 2 years ago | (#40097001)

Now it's all over my hands. Dang.

thump thump

Pics or it didn't happen (0)

Anonymous Coward | more than 2 years ago | (#40097179)

Pics or it didn't happen

All skin cells? (1)

Czubaka (132534) | more than 2 years ago | (#40097263)

Now image, a mad scientist with a skin cells changing blaster hiding in the dark corner, waiting to change all your skin into little beating hearts. Aaaaarrrgh!!!

T.I.I.T. (0)

Anonymous Coward | more than 2 years ago | (#40097445)

With abbreviation like that, i bet i know which tissue they will be working on next...

Young except for the telomeres...? (1)

rgbatduke (1231380) | more than 2 years ago | (#40098451)

Actually, this is in part a question. Although I could probably read TFA to find out (maybe it answers this) but one issue with rejuvenation is rewinding the telomeres (so to speak) so they aren't too long (cancer) and aren't too short (premature cell death). There are a lot of clocks in cells and tissue, and my general question is: Does skin -> stem -> tissue cell reset them all so that the new tissue really is "like that of a newborn" or whatever with the original DNA complement?

Not good to be able to build the heart of a Chicken Little (props for ref:-) that simply up and dies on you, or gets cancer, for other reasons.

rgb
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