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Scientists Grow Replacement Human Teeth In Mouse Kidneys

samzenpus posted about a year and a half ago | from the does-this-taste-funny-to-you? dept.

Science 117

sciencehabit writes "When an adult loses a tooth, there's no hope of growing a new one—unless you've got a mouse kidney handy. In a new study, researchers injected human gum tissue extracted during oral surgery into the molars of fetal mice. After giving the cells a week to get used to each other, the scientists implanted the chimeric concoction into the protective tissue surrounding the kidneys of living mice. There, 20% of the cells developed into objects recognizable as teeth, complete with the root structures missing from artificial tooth implants. The next step is to transplant these so-called 'bio-teeth' back into human mouths and see if they grow into something that we can chew on—or rather, with."

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They wash them (5, Funny)

i kan reed (749298) | about a year and a half ago | (#43137779)

No need to worry about how gross that sounds, they wash them before putting them in, using a special sterilizing soap grown from a rat's testicles.

Re:They wash them (4, Funny)

tippe (1136385) | about a year and a half ago | (#43138071)

Nicholson [pointing a gun at DiCaprio]: I taste a rat!
DiCaprio: Those are you're new implants, boss!
Nicholson [putting gun away]: Oh yeah. It's going to take some time to get used to these...

Re:They wash them (-1)

Anonymous Coward | about a year and a half ago | (#43138355)

Those are you are new implants?? There are way too many aliterates at slashdot these days. It's YOUR, moron.

And no, "aliterate" isn't a misspelling. Look it up.

Re:They wash them (0)

tom17 (659054) | about a year and a half ago | (#43138663)

Sorry, but he is NOT myre moron!

Re:They wash them (5, Informative)

tippe (1136385) | about a year and a half ago | (#43138785)

YOU'RE totally right; my mistake. I noticed the error after I had already posted, but of course by then it was too late to change it. English grammar has never been a strength of mine, although I usually do OK all things considered (French is my primary language). The choice between your/you're and its/it's has always required a conscious decision on my part and does not come naturally to me, and in my rush to post the comment earlier I made that terrible mistake. Sorry that you were so offended by it that you felt the need to reach out and personally attack me. I'll try to be more considerate of your sensitivities in the future...

Re:They wash them (1)

CannonballHead (842625) | about a year and a half ago | (#43139321)

Please ignore those Americans who forget there are other languages spoken in the world and that, typically, those other-language speakers actually know English quite well...

(I am on a teleconference right now with some French Canadians and Danes... all speaking English...)

- A non-offended American. :P :)

Vagina Dentata (1)

Jeremiah Cornelius (137) | about a year and a half ago | (#43140415)

Vagina Dentata! What a wonderful phrase
Vagina DentataI Ain't no passing craze
It means no worries for the rest of your days
It's our problem-free philosophy
Vagina Dentata!

Re:They wash them (2)

Hoi Polloi (522990) | about a year and a half ago | (#43138257)

Problem is after inserting them you have a craving for cheese.

Craving for cheese is perfectly normal. Squeak. (1)

denzacar (181829) | about a year and a half ago | (#43139129)

And so is dressing and acting as a mouse. Squeak. [youtube.com]

How do rat's pass that? (3, Insightful)

kimgkimg (957949) | about a year and a half ago | (#43139469)

Ouch, talk about a nasty kidney stone...

Re:They wash them (1)

Synerg1y (2169962) | about a year and a half ago | (#43141429)

I'd imagine after getting these teeth added, one would develop a new fondness for cheese...

First? (0, Offtopic)

jbmartin6 (1232050) | about a year and a half ago | (#43137781)

let me be the first to state that the editors are all incompetent and the quality of comments on /. is execrable

Really, a fake tooth is fine, thanks (4, Funny)

Anonymous Coward | about a year and a half ago | (#43137789)

As tempting as putting something in my mouth grown from a mouse's kidney sounds, I'll just take a crown or some bridgework, thanks.

Re:Really, a fake tooth is fine, thanks (0)

Mystakaphoros (2664209) | about a year and a half ago | (#43137851)

Besides, I need room in my mouth for my explodo-molar.

Re:Really, a fake tooth is fine, thanks (2)

tmosley (996283) | about a year and a half ago | (#43138077)

Really? Because I would like to be able to chew gum without terror.

Re:Really, a fake tooth is fine, thanks (0)

Anonymous Coward | about a year and a half ago | (#43138561)

And yet you probably have no problem eating meat. The world really needs to get over the biotech yuck factor.

Re:Really, a fake tooth is fine, thanks (1)

Anonymous Coward | about a year and a half ago | (#43139653)

A predator that has no problem eating meat? What a concept!

Re:Really, a fake tooth is fine, thanks (2)

G0m3r619 (2860797) | about a year and a half ago | (#43139017)

This isn't saying they would use the mouse method on humans... (face-plant) They are just saying they found what kind of cells they need to promote the growth of a natural tooth from these cells. If you bothered to read the article you'd know they are now looking for a cheap and easy way to get human mesenchymal cells the make this a viable option for use on human patients.

Re:Really, a fake tooth is fine, thanks (0)

Anonymous Coward | about a year and a half ago | (#43140201)

I had a dentist who wanted to replace a missing tooth with a cadaver tooth. I told him there was zero chance that I was going to let him implant a dead person's tooth in my mouth.

Re:Really, a fake tooth is fine, thanks (1)

K. S. Kyosuke (729550) | about a year and a half ago | (#43140853)

I had a dentist who wanted to replace a missing tooth with a cadaver tooth. I told him there was zero chance that I was going to let him implant a dead person's tooth in my mouth.

In that case, pray that you'll never need an organ transplant in your life. (Although in this case, it seems weird that a randomly chosen human tooth would be properly sized. They take classes for just that, how to make the artificial stuff properly sized so that it would fit.)

The Dark Half? (0)

Anonymous Coward | about a year and a half ago | (#43137791)

that's the first thing I thought of..

They've got this backwards. (4, Insightful)

Anonymous Coward | about a year and a half ago | (#43137793)

They would find it much more lucrative if they could figure out a way to grow replacement KIDNEYS.

Re:They've got this backwards. (1)

karnal (22275) | about a year and a half ago | (#43138089)

Maybe the universe would collapse if you tried to grow a kidney in a kidney.

Re:They've got this backwards. (0)

Anonymous Coward | about a year and a half ago | (#43138253)

Yo dawg, I heard you needed a kidney...

Re:They've got this backwards. (1)

K. S. Kyosuke (729550) | about a year and a half ago | (#43140871)

Maybe the universe would collapse if you tried to grow a kidney in a kidney.

You can grow anything in anything! Welcome to the fractal people universe [wikipedia.org] ...it's Mandelbrot all way down!

Re:They've got this backwards. (1)

Opportunist (166417) | about a year and a half ago | (#43138569)

They tried, but the mouse exploded.

Re:They've got this backwards. (4, Insightful)

dietdew7 (1171613) | about a year and a half ago | (#43138971)

We already grow replacement kidneys in the bodies of third world humans.

Re:They've got this backwards. (0)

Anonymous Coward | about a year and a half ago | (#43139871)

Shssssh! That's a secret!

Re:They've got this backwards. (0)

Anonymous Coward | about a year and a half ago | (#43140345)

We already grow replacement kidneys in the bodies of third world humans.

I thought you were going to say it's why the govt. has repealed motorcycle helmet laws.

Re:They've got this backwards. (0)

Anonymous Coward | about a year and a half ago | (#43139961)

That's like saying that opening an iron mine is stupid because you'd make more money mining uranium.

Growing organs in general is an open research topic and teeth are an attractive first target because there is demand for replacement teeth, but the patient doesn't die if the replacement doesn't work out. Teeth are also a lot less complex than kidneys.

Re:They've got this backwards. (2)

FauxReal (653820) | about a year and a half ago | (#43140371)

They would find it much more lucrative if they could figure out a way to grow replacement KIDNEYS.

But imagine the size of a kidney grown inside a mouse tooth, they'd have to stitch together thousands to get anything useful!

test (-1)

Anonymous Coward | about a year and a half ago | (#43137799)

test

Moe, Larry... (-1)

Anonymous Coward | about a year and a half ago | (#43137805)

the cheese!

So-called (1)

Anonymous Coward | about a year and a half ago | (#43137815)

So-called "bio-teeth" ...as opposed to WHAT?

Re:So-called (1)

tmosley (996283) | about a year and a half ago | (#43138103)

Craniofacial implants.

Re:So-called (1)

newcastlejon (1483695) | about a year and a half ago | (#43139967)

So-called "bio-teeth" ...as opposed to WHAT?

Porcelain?

Re:So-called (1)

worf_mo (193770) | about a year and a half ago | (#43140285)

Exactly, either porcelain or acrylic teeth. Right now I'm sitting next to one of several teeth production lines in a customer's plant (writing custom software for the machines).

Re:So-called (1)

K. S. Kyosuke (729550) | about a year and a half ago | (#43141747)

So, you've decided to cut your meta-teeth on writing teeth-making software?

It sounds good but (5, Funny)

Chrisq (894406) | about a year and a half ago | (#43137829)

It sounds good but the instruction was to grow human kidneys in rats teeth. It was a real Do'h moment when the researcher reread his brief!

Why not just grow it in our mouth. (3, Interesting)

FictionPimp (712802) | about a year and a half ago | (#43137837)

So they take tissue out of your mouth, put it in a mouse, then grow the tooth. Why not just grow the tooth in your own mouth?

Re:Why not just grow it in our mouth. (1)

SuricouRaven (1897204) | about a year and a half ago | (#43137891)

Because the developing tooth is far too fragile, I assume. It'd be squished the moment you chewed anything. Or poked it with your tongue.

Re:Why not just grow it in our mouth. (2)

FictionPimp (712802) | about a year and a half ago | (#43137925)

I've already grown two sets of teeth in my mouth! Seems plausible...

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43138691)

Really? Most people grow them in the relative safety of their jaws.

Re:Why not just grow it in our mouth. (1)

SuricouRaven (1897204) | about a year and a half ago | (#43140167)

The process of moving the tooth from jaw to mouth is rather painful, even in children - where the teeth are ready to come out anyway.

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43140341)

WTF are you talking about? Painful my ass. It is merely uncomfortable, even with wisdom teeth.

Re:Why not just grow it in our mouth. (1)

geminidomino (614729) | about a year and a half ago | (#43141559)

You must be one of the lucky ones whose wisdom teeth erupted in the right direction.

When they come out the side of your gums, hoo boy. "Painful" doesn't even begin to cover it.

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43138949)

Or took a sip of what people drink nowadays...

Re:Why not just grow it in our mouth. (5, Funny)

Mystakaphoros (2664209) | about a year and a half ago | (#43137901)

My guess is that it's a little easier to euthanize a mouse when something goes horribly, horribly wrong.

Re:Why not just grow it in our mouth. (4, Funny)

saveferrousoxide (2566033) | about a year and a half ago | (#43138175)

I don't know...maybe it's just me, but teeth growing out of my kidney sounds like something gone horribly, horribly wrong...

Re:Why not just grow it in our mouth. (1)

RabidReindeer (2625839) | about a year and a half ago | (#43138573)

I don't know...maybe it's just me, but teeth growing out of my kidney sounds like something gone horribly, horribly wrong...

Kidney stones. With a vengeance!

Poor mousey.

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43138589)

It sounds horrifically painful for the mouse. If we can grow meat in a vat, we can do the same with teeth without torturing animals.

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43140651)

better than teeth growing out of a vag

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43140291)

My guess is that it's a little easier to euthanize a mouse when something goes horribly, horribly wrong.

Yes, but they've also made it a little easier for the mouse to bite back.

Re:Why not just grow it in our mouth. (1)

MozeeToby (1163751) | about a year and a half ago | (#43137909)

Because it's a lot harder to get approval for an animal trial than a human trial? Especially when said trial involves injecting things into your molars? And for a more science centric reason, it maybe be that the environment of the kidneys is essentially to the actual regrowing teeth part.

Re:Why not just grow it in our mouth. (-1)

Anonymous Coward | about a year and a half ago | (#43137927)

Because Science, bitch!

Actually, they did (2)

pablo_max (626328) | about a year and a half ago | (#43137963)

Funny enough, they did do just that a couple years ago. Doesn't seem like anything came from it.
http://www.popsci.com/science/article/2010-05/new-technique-uses-bodys-stem-cells-regenerate-teeth [popsci.com]

Re:Actually, they did (0)

Anonymous Coward | about a year and a half ago | (#43139477)

Like many cool researches, it's been "5years away" for more than 10 years now. I've been fanatic about cleaning my third molars for more than 20 years trying to keep them healthy for the day they succeed at this.

Something you youngin's don't seem to realize: if you live long enough, every small filling will eventually become a large filling, every large filling will eventually become a crown, every crown will eventually become a root canal and every root canal will eventually become a lost tooth. Getting old is a race to die before your parts fail.

Re:Why not just grow it in our mouth. (2)

luther349 (645380) | about a year and a half ago | (#43138219)

to be honest the fake implants are better then the real thing. they never go bad again. putting real ones back would just bring back the same issue a few years down the road teeth going bad again.

Grow it in your ovary. (2, Informative)

Anonymous Coward | about a year and a half ago | (#43138221)

My wife has a "Dermoid Cyst", which is a benign tumor on one of her ovaries. It's filled with skin, hair, and teeth. That's right. Fully developed adult human teeth. Molars, actually. Often they're discovered when the teeth show up on an abdominal x-ray.

It's simultaneously very fascinating and very creepy. Google image search for "dermoid cyst". The human body is a weird thing.

Re:Grow it in your ovary. (4, Insightful)

zifferent (656342) | about a year and a half ago | (#43138465)

Warning! Do not. I repeat do not do a Google Image search on "Dermoid Cyst" There is not enough brain bleach in the universe.

Re:Grow it in your ovary. (1)

wierd_w (1375923) | about a year and a half ago | (#43138665)

Oh come on, you KNOW you are just BEGGING for a "Fetus in fetu" type teratoma to show up on your high resolution gaming monitor, in spectacular color and detail.

It's the perfect chaser to googling a dermatoid cyst for images.

You'll never feel quite the same again once you learn they often grow from pluripotent stemcells making their way into improper places.

Re:Grow it in your ovary. (1)

i kan reed (749298) | about a year and a half ago | (#43141445)

Not that I am one, but surely an M.D. would need to be able to tolerate the appearance.

Re:Grow it in your ovary. (1)

dietdew7 (1171613) | about a year and a half ago | (#43139001)

There are worse places for your wife to have teeth.

Re:Why not just grow it in our mouth. (1)

mesri (993588) | about a year and a half ago | (#43138255)

Presumably that would _hurt_. Have you ever seen how much agony a teething baby is in?

Re:Why not just grow it in our mouth. (0)

Anonymous Coward | about a year and a half ago | (#43138379)

Conditions just wouldn't be right..
Just like if you tried to bake a cupcake in your mouth instead of the oven.

Re:Why not just grow it in our mouth. (1)

skids (119237) | about a year and a half ago | (#43138529)

This.

Though I suspect this is a first step towards that goal.

Re:Why not just grow it in our mouth. (1)

Dr. Evil (3501) | about a year and a half ago | (#43139429)

Because they couldn't?

""The next major challenge is to identify a way to culture adult human mesenchymal cells to be tooth-inducing, as at the moment we can only make embryonic mesenchymal cells do this.""

Two reactions (0)

Anonymous Coward | about a year and a half ago | (#43137945)

First reaction: cool. Really interesting seeing where the capability is going. Seems like we get an article like this every few weeks. Baby steps towards doing things to help people out that even science fiction could not predict.

Second reaction: It's gotta suck being a mouse.

That's one hell of a kidney stone (1)

tippe (1136385) | about a year and a half ago | (#43137973)

Sucks to be that rat when it comes time to harvest those teeth...

Re:That's one hell of a kidney stone (1)

hrvatska (790627) | about a year and a half ago | (#43138675)

On the other hand, if that rat was growing my replacement tooth, up until it was time to harvest the tooth that rat would be the most pampered rat in the world.

Finally, we caught up to Sharks (1)

gurps_npc (621217) | about a year and a half ago | (#43138117)

In our millennium long attempt to become King of All the Predators, we have finally caught up to the Shark.

Now, NOTHING can stand against us!

Crown us King of the Earth and the SEAS!

P.S. I already know humans kill more sharks than sharks kill humans. But darn it, they smiled too much when we kill them. Now we can do it BACK.

But do the mice then... (2)

gestalt_n_pepper (991155) | about a year and a half ago | (#43138159)

bite the hand that feeds them?

Re:But do the mice then... (0)

Anonymous Coward | about a year and a half ago | (#43138299)

It's just another way to sink teeth into mice... without having to taste them.

Difficulties (5, Informative)

teethdood (867281) | about a year and a half ago | (#43138167)

I am a dentist One of the benefits cited in the fine article is that the kidney-grown tooth structures more closely resemble a real tooth with a physical root. The root system of a tooth is much more complex than just its physical shape. Within a tooth socket, you have the periodontal ligament surrounding the root separating the jaw bone from the root. Then you have the root itself with cementum layer, dentin layer, then pulp. Even if we were to be able to grow a tooth outside the mouth, it doesn't mean all the necessary structures are there. When transplanting a grown tooth, you're faced with several obstacles: 1) Bone socket must be created to the exactly fit the tooth 2) Creating the periodontal ligament to provide cushion, natural tooth movements, and the ability to extract that tooth without it fusing to the bone 3) The pulp tissue needs to be connected somehow to the nerve and blood systems, otherwise you would have to do a root canal to remove the pulp 4) The morphology of the crown portion above the gum needs to be correct, meaning the tooth needs a crown So, while being able to induce cells to grown into something that looks like a tooth is a step forward, at this point it is far from a viable treatment option versus a titanium implant which has a known shape/diameter/length. The golden ticket is when we can induce mesenchymal stem cells to grow into a tooth directly in the jaw (hopefully with the correct morphology due to its position next to adjacent teeth as well).

Re:Difficulties (0)

Anonymous Coward | about a year and a half ago | (#43138601)

I understood some words in this.http://science.slashdot.org/story/13/03/11/129245/scientists-grow-replacement-human-teeth-in-mouse-kidneys#

Re:Difficulties (3, Informative)

wierd_w (1375923) | about a year and a half ago | (#43139315)

Agreed, the perfect solution is the one that generates teeth already.

The issue with fibroblasts in adult human tissue, is that they don't form a blastema upon "injury". (unless you are a reptile, or certain kinds of fish.) I mention fibroblasts, because they are the creators and components of the extracellular matrix, which helps undifferentiated cells to understand where in the host they have found themselves.

In mammals, fibroblasts "regenerate" damage as scar tissue, instead of forming the blastema. In regenerating lizards and the like, they form this structure, which essentially regrows the missing or damaged tissue using stemcells from the host's blood supply, which migrate to the blastema, attach, then begin regrowing the damaged or amputated feature following the embryonic blueprint, using HOX gene activation of the supporting fibroblast matrix as a signpost.

The ideal solution, would be to collect a sample of tissue from a recently extracted diseased molar, culture it in a petri dish, and use a chemical cocktail to force it to become a blastema, which would then be reinserted into the jaw later. This ensures proper HOX activation for the site from the tissue culture, which helps ensure that the resulting tissue from the blastema will not only be a tooth, but also the CORRECT tooth.

It is important to note that the location in the body from which the fibroblasts harvested to create these blastema is critical in determining "what" will grow. Several experiments were performed on salamanders, where a lesion was purposefully created, then the blastema translocated to a different location on the host surgically. The result was the induction of grown limbs in inappropriate places, (such as tails and legs in the middle of the back), at the sites of translocation. Once the blastema has formed, it has already begun the developmental program for what will be produced. It is believed this is due to the activation state of bodyplan HOX genes in the fibroblasts involved in the blastema's creation, according to several gene expression assays performed.

This means that the tooth formed by a dental blastema would be highly dependent upon where in the mouth the cell culture was taken, and the presence of scar tissue being extent or not. It would be a very good idea to write down that information when taking your samples for culture, and not mixing the samples up on implantation. :D

It is personal conjecture time, but personally, I think that a cultured then frozen blastema could be later reintroduced as a grown tooth bud after the bone tissue has healed in the extraction channel, and after the in vitro blastema has had sufficient time to decide which way it will make its root structure, to reduce the risks of "serious complication", which needless to say, would require very invasive surgery to correct, as well as for it to develop diagnostic criteria for ensuring proper orientation and clocking for insertion. (The transplanted tissue bud would be about the size of a grain of milo, or smaller at this stage of development. Just enough to know which way it is pointed, and to get some diagnostic data for proper insertion from.) This way the introduced blastema would grow and integrate with the jaw in the appropriate fashion, though it would be a good idea to monitor its growth to ensure it was properly inserted, and is not going to cause an impaction later. (Somehow I doubt most insurance would cover the added expenses over that of a prosthetic device though, and they bitch enough about those. As such, I dont see this happening any time soon, but I don't see a major obstacle against it biologically/technologically. Bureaucratically is another issue entirely!)

Even if the resulting dental crown is abnormal, this at least produces a healthy root structure, (at least in theory), which would allow surgical correction with more traditional techniques, as required.

Naturally, this process needs to be performed in animals many times to work out all the risks of complications and to develop a standard protocol for the therapy before being used routinely in humans. (Unless you WANT to see horror stories in the press about people needing half their jaw amputated after a botched job, anyway...)

It would likely be after decades of routine practice with such a procedure that any advancements allowing an earlier stage blastema to be introduced safely and reliably could become a medical reality. Hopefully we can get that experience from animal models without risking human patients.

Science has gone too far (0)

Anonymous Coward | about a year and a half ago | (#43138279)

What the fuck is wrong with these people? Sure, it's cool, interesting, revolutionary, but FUCK! Who the fucking fuck woke up one morning and thought "I'm going to grow human teeth in mouse kidneys!"

Calm Down Al... (1)

Dareth (47614) | about a year and a half ago | (#43138537)

Calm Down Al... drink your warm spider milk [slashdot.org] . It will help calm your nerves.

A matter of taste (1)

Ukab the Great (87152) | about a year and a half ago | (#43138291)

Would the teeth be considered less disgusting if they were grown in a cow's buttocks? Besides, plenty of people in western culture eat kidneys already. Your steak and kidney pie will probably taste better coming off of a fork with teeth than coming out of a straw.

Re:A matter of taste (1)

DigiShaman (671371) | about a year and a half ago | (#43138475)

Speaking of taste, I now have a sudden craving for cheese.

One caveat: cancer. (1)

Anonymous Coward | about a year and a half ago | (#43138309)

They're still using stem cells. It would be much greater to find the solution or protein that triggers your body to just produce a new set of teeth.

The end of the article source is pretty depressing. 10-15 years away from human trials. They said that 10-15 years ago. I've been watching this research for a long time, as I was one of those kids that lived on mt. Dew soda. Ugh! I was particularly excited when they released a treatment for gum tissue repair this year. [sciencedaily.com]

Captcha: puppies

Re:One caveat: cancer. (1)

1u3hr (530656) | about a year and a half ago | (#43140215)

The end of the article source is pretty depressing. 10-15 years away from human trials. They said that 10-15 years ago.

Longer. I've been reading reports a bit this kind of research every couple of years for at least 20 years. And now every year or two I have to have a root canal, and/or crown, or just extraction. My time is running out before I end up like my father with full dentures.

What happend to LIPUS? (1)

Jmc23 (2353706) | about a year and a half ago | (#43138361)

Where you could just regrow your tooth in your own jaw and heal your teeth? ...besides the fact that it would put every single dentist out of work.

I guess the same thing that happened to the techniques to restore your eyesight.

Never trust a person who makes a living off of you staying sick and helpless.

Re:What happend to LIPUS? (2)

compro01 (777531) | about a year and a half ago | (#43139149)

AFAICT, the LIPUS stuff got run through the science-to-media translation matrix and overhyped, as usual.

The "grow new teeth" thing was the result of a study (by Dr. Tarek El-Bialy at the University of Alberta) of it in rabbits, who already have continuously-growing teeth, so presumably provoking the growth of new teeth is a relatively simple task.

In humans, it seems to be mostly useful as a potential treatment for root resorption or to supplement stem cell-based regrowth.

Re:What happend to LIPUS? (1)

captjc (453680) | about a year and a half ago | (#43139199)

...besides the fact that it would put every single dentist out of work.

No it wouldn't. Someone has got to perform the procedure, might just as well be a dentist. Besides, it wouldn't exactly fix the problems of crooked, impacted, or malformed teeth, so even with this technology, there will still be a need for qualified dentists.

Just imagine the mouse passing the tooth (1)

scorp1us (235526) | about a year and a half ago | (#43138485)

PETA should be all over this! Imagine passing a molar through your tiny mouse urethra!

That awkward moment... (1)

taiwanjohn (103839) | about a year and a half ago | (#43138599)

When you realize you're not reading an "April Fools'" headline... Seriously, this looks like a story you'd see on The Onion, not SienceMag. We live in interesting times, indeed.

Fucking ow... (0)

Anonymous Coward | about a year and a half ago | (#43138727)

As someone who has suffered from kidney stones in the past, I can't imagine the pain caused by friggin' **TEETH** growing there.

Is there some wonderful magical quality about mouse kidneys as opposed to some other less nerve-infused part of their body? Because those mice had to be in agony.

Re:Fucking ow... (1)

javamage (1966164) | about a year and a half ago | (#43139777)

I've had stones before too... They're not painful in the kidney; only in the ureter (the tube between the kidneys and bladder).

cosmetic teeth (1)

mynameiskhan (2689067) | about a year and a half ago | (#43138845)

If teeth is a cosmetic product, then it is going to work in EU - http://www.nytimes.com/2013/03/11/business/global/eu-to-ban-cosmetics-with-animal-tested-ingredients.html [nytimes.com] . But unfortunately, it is not cosmetic except for insurance purposes. So the mice will have to endure this humans digging for tooth.

Because why not? (1)

Captain Spam (66120) | about a year and a half ago | (#43138865)

Human teeth from mouse kidneys. Because why the hell not? Next week, we'll start on our project to make alligator spleens from parrot intestines. Time permitting, there's always the cheetah-bones-from-elephant-skin plan or the one where we make dog fur from jellyfish stingers. If we get enough funding, we might be able to complete our magnum opus, recreating the heart of a triceratops from the colon of a neanderthal!

Yeeaaoowch! (1)

Tarlus (1000874) | about a year and a half ago | (#43138893)

What a painful stone that would be to pass.

Re:Yeeaaoowch! (0)

Anonymous Coward | about a year and a half ago | (#43141853)

Mod parent up.

Having had a calcium kidney stone - that was only 2-3mm in diameter... I can't imagine what it would be like to have an elephant tusk growing in my kidney...

"Has anyone seen my teeth?" (1)

guttentag (313541) | about a year and a half ago | (#43140245)

Puts a new twist on grandpa's: "Has anyone seen my teeth?"

"Relax, grandpa, they're right here in these mice kidneys. Just try to remember not to soak the mice in Efferdent overnight. This one's still foaming at the mouth."

The sociopaths of Slashdot are loose... (0)

Anonymous Coward | about a year and a half ago | (#43140937)

... I see that none of you can even begin to imagine the pain and suffering of those animals.

When do you plan on becoming adults?

Yeah, but everything afterwards tastes like mouse! (0)

Anonymous Coward | about a year and a half ago | (#43141439)

Try the liver.
I'll be here all week.

Horrible horrible error (1)

EmperorOfCanada (1332175) | about a year and a half ago | (#43141471)

I just don't want rat kidneys then growing in my mouth.

My teeth are floating (0)

Anonymous Coward | about a year and a half ago | (#43142123)

For real this time.

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