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Bandages That Can Turn Off Genes Encourages Wound Healing

samzenpus posted about a year ago | from the all-in-one-healing dept.

Medicine 54

MTorrice writes "Medical researchers think specially tailored RNA sequences could kill tumor cells or encourage wound healing by turning off genes in patients' cells. Now researchers have developed a nanocoating for bandages or other medical materials that could deliver these fragile gene-silencing RNAs right where they're needed. The team hopes to produce a bandage that shuts down genes standing in the way of healing in chronic wounds."

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54 comments

BE HEALED !! (-1)

Anonymous Coward | about a year ago | (#43810375)

Being well healed is always a good thing !!

Re: BE HEALED !! (-1)

Anonymous Coward | about a year ago | (#43810393)

By nanobots the future of religion.

Re: BE HEALED !! (-1)

Anonymous Coward | about a year ago | (#43810411)

By nanobots the future of religion

Re:BE HEALED !! (0)

Anonymous Coward | about a year ago | (#43810999)

Ask any doctor, being well heeled is part of the game.
But, what with all the endless side effects of modern medicine, I really couldn't give a crap what medical researchers think. It doesn't amount to healing so much as experimenting for profit, driving up medical costs for dreadful mistakes and somehow justifying a misanthropic modern education in medicine.
These pussheads are in the early stages of understanding genes in the first place, but they're ready to come out swingin with some NEW medicine that MIGHT help,PROBABLY cause worse problems and continue to FUND their illbegotten careers. Hey Madame Curie died ages ago, you aren't going to impress anyone with this modern philosophy.

          "Doctors put drugs of which they know little into bodies of which they know less for diseases of which they know nothing at all." --Voltaire

          "The role of the doctor is to amuse the patient whilst nature takes its course".--Voltaire again

Re:BE HEALED !! (2)

nospam007 (722110) | about a year ago | (#43811519)

" "Doctors put drugs of which they know little into bodies of which they know less for diseases of which they know nothing at all." --Voltaire

                    "The role of the doctor is to amuse the patient whilst nature takes its course".--Voltaire again"

That works only for the malade imaginaire.

Leg fell off (1)

jamesh (87723) | about a year ago | (#43810397)

I wonder if it can cure a nasty case of "leg fell off"?

Re:Leg fell off (0)

Anonymous Coward | about a year ago | (#43810437)

No, only a miracle could cure that. Ah, wait, not even a miracle. Yahweh only makes miracles that cannot be discerned from pure chance, because you must keep believing only by faith!

Re:Leg fell off (0)

Anonymous Coward | about a year ago | (#43810469)

For this article summary, more like "leg fall off" :-/

Re:Leg fell off (4, Interesting)

ras (84108) | about a year ago | (#43810805)

I wonder if it can cure a nasty case of "leg fell off"?

No.

But if you are under the age of 6, not wrapping a finger in a bandage means it will probably grow back. From www.abc.net.au/radionational/programs/scienceshow/4632692 [abc.net.au] (click on Transcript):

Dany Adams: It's interesting, in humans if you were six years old and you cut the tip of your finger off it would grow back, as long as the doctors do not do the normal thing, which is to pull some skin and cover the wound to prevent infection, which is a very good thing to do, but if you don't do that and you allow it to stay open, it will in fact regenerate if you are six years old.

Re:Leg fell off (2)

Dcnjoe60 (682885) | about a year ago | (#43811593)

I wonder if it can cure a nasty case of "leg fell off"?

No.

But if you are under the age of 6, not wrapping a finger in a bandage means it will probably grow back. From www.abc.net.au/radionational/programs/scienceshow/4632692 [abc.net.au] (click on Transcript):

Dany Adams: It's interesting, in humans if you were six years old and you cut the tip of your finger off it would grow back, as long as the doctors do not do the normal thing, which is to pull some skin and cover the wound to prevent infection, which is a very good thing to do, but if you don't do that and you allow it to stay open, it will in fact regenerate if you are six years old.

That's assuming the open wound doesn't become septic and you die from the infection, of course.

Re:Leg fell off (1)

sjames (1099) | about a year ago | (#43819553)

We have ways of preventing the infection.

Re:Leg fell off (1)

Dcnjoe60 (682885) | about a year ago | (#43820697)

We have ways of preventing the infection.

Yes, we do. First, one of the steps being that you wrap the finger in a bandage to keep bacteria away from it.

Re:Leg fell off (1)

sjames (1099) | about a year ago | (#43823641)

Which is fine as long as the bone isn't trimmed and the wound closed with stitches as is normally done.

Wec also have antibiotic ointments.

Re:Leg fell off (0)

Anonymous Coward | about a year ago | (#43815969)

The supplied link, while fascinating, is not the source of your quote.

That quote comes from a week previous: http://www.abc.net.au/radionational/programs/scienceshow/regenerating-body-parts/4623764

Re:Leg fell off (-1)

Anonymous Coward | about a year ago | (#43810971)

No. God hates amputees.

Re:Leg fell off (1)

Vreejack (68778) | about a year ago | (#43810987)

Matthew Hagee says that praying for healing in Jesus' name always cures everything. Except a case of the stupids.

http://www.rightwingwatch.org/content/hagee-healing-jesus-name-works-every-time [rightwingwatch.org]

Re:Leg fell off (1)

jamesh (87723) | about a year ago | (#43817753)

Matthew Hagee says that praying for healing in Jesus' name always cures everything. Except a case of the stupids.

http://www.rightwingwatch.org/content/hagee-healing-jesus-name-works-every-time [rightwingwatch.org]

If prayer isn't curing stupidity then you obviously aren't praying hard enough, or praying to the wrong god(s).

Re:Leg fell off (1)

VortexCortex (1117377) | about a year ago | (#43811561)

I wonder if it can cure a nasty case of "leg fell off"?

Just glue the pieces together. Duh. It's not like you have to take them apart, you can just buy mor-- wait, wrong story, thought this tab was the Lego Xwing story.

Nanotech + engeneering (1)

chaos_technique (1191999) | about a year ago | (#43810483)

What could possibly go wrong?

Grey goo? I Am Legend (Will Smith edition)?

Re:Nanotech + engeneering (0)

Anonymous Coward | about a year ago | (#43810583)

Improved spelling?

Re:Nanotech + engeneering (1)

chaos_technique (1191999) | about a year ago | (#43810631)

Twas actually a neologism splicing "engineering" and "gene". But it failed miserably, obviously.

Re:Nanotech + engeneering (0)

Anonymous Coward | about a year ago | (#43812129)

It's too bad that technical stagnation and social decay doesn't make for good science fiction, otherwise non-creative scaremongers would have opposed not doing things too.

That would be a Godsend (5, Interesting)

hardburlyboogerman (161244) | about a year ago | (#43810587)

For Type 1 diabetics,like myself.We are plagued by non-healing chronic open wounds that set up into gangrene.I lost my right foot to such a wound that started as a blister

Re:That would be a Godsend (-1, Troll)

Lord Maud'Dib (611577) | about a year ago | (#43810595)

And the inability to appropriately use the space bar?

Re: That would be a Godsend (0, Insightful)

Anonymous Coward | about a year ago | (#43810625)

You asshole

Re:That would be a Godsend (0, Insightful)

Anonymous Coward | about a year ago | (#43810851)

And the inability to appropriately use the space bar?

What a cunt you are.

Re:That would be a Godsend (-1)

Anonymous Coward | about a year ago | (#43810903)

You insensitive, cruel fuckface. You should be ashamed.

Re:That would be a Godsend (1, Offtopic)

RabidReindeer (2625839) | about a year ago | (#43810993)

And the inability to appropriately use the space bar?

What? YOU don't operate the spacebar with your right foot?

Just because you're one of those morally-questionable left-footed people doesn't give you the right to be an insensitive clod!

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43816045)

UnlikeotheranonymouscowardsIdon'tcareifyouinsultpeoplewhodon'tusethespace
barproperly.

Re:That would be a Godsend (-1)

Anonymous Coward | about a year ago | (#43811137)

No you stupid single-foot, it's a Scientist-send, there is no god. Garbage like you should not even be given access to this technology, since it is garbage like you that stands in the way of progress with your religious bullshit.

Re:That would be a Godsend (-1)

Anonymous Coward | about a year ago | (#43811355)

And here is why we don't want atheists ruling the world. And we don't want theists running the world either. Leaves us with very few options.

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43812263)

I doubt it; God already 'sent' you diabetes, so she must hate you.

This would be a scientists'send.

Re:That would be a Godsend (1)

hardburlyboogerman (161244) | about a year ago | (#43812535)

I got diabetes after getting sucker punched by a psych patient who I stopped from killing a nurse.Thanks to that Jackass,I have no pancreas to make insulin.If it isa any consolation,he got himself killed not a month later.At least I'm still alive.

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43816865)

I didn't know you could actually receive severe trauma to the pancreas from a punch... That sucks.

No good deed goes unpunished, it seems, and major good acts can have life-threatening consequences. Your diabetes and missing foot are badges of honor.

(different AC than the GP)

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43818355)

"Death, The Consoler?"
Only if you're as messed up as he was, perhaps. Then again, time and travail can bring a more generous maturity. But then, it was all his fault. All that needing more than what life would grant him. All that not understanding why life didn't want him to feel any pleasure. The pleasure he "needed". Why it didn't want to allow the "pain" to go away.
By the way (I'm sure that, as a /.ter, you already know this), just for the sake of optimism : https://www.youtube.com/results?search_query=artificial+OR+printed+pancreas [youtube.com]
  https://www.youtube.com/results?search_query=pancreas+regenerative+medicine [youtube.com]

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43814191)

Holy shit!!! I had no idea type 1 diabetes could be so dangerous. I hope you don't lose anything else!

Re:That would be a Godsend (0)

Anonymous Coward | about a year ago | (#43818629)

I'd never heard about diabetic foot ulcers. I made the mistake of doing a google image search for it. Yikes :(

Junk DNA (0)

Anonymous Coward | about a year ago | (#43810599)

Researchers can't seem to make up their mind if "junk" DNA is actually junk or not, but they want a way to mess with it anyway? I really hope they test these things on themselves first.

Re:Junk DNA (0)

Anonymous Coward | about a year ago | (#43815917)

Researchers can't seem to make up their mind if "junk" DNA is actually junk or not, but they want a way to mess with it anyway? I really hope they test these things on themselves first.

Well that is how science works. Don't know what a thing does? Mess with it until you figure it out!

What's being 'silenced' here? (3, Insightful)

waterbear (190559) | about a year ago | (#43810629)

Obviously one crucial element in the safety/efficacy of anything like this is the identity of the gene/protein involved:-- what exactly is being 'silenced' here and taken away from the wound-healing process?

Whatever, it's not mentioned in either the /. summary or either of the links referred to. So there's no real clue in the story, or in the links, about whether the application of this delivery technique is likely to be beneficial or the reverse.

Informative reportage?

Re:What's being 'silenced' here? (5, Informative)

TrashGod (752833) | about a year ago | (#43810819)

The idea is to down-regulate the production of protein(s) that induce cellular senescence in chronic wounds, for example [nature.com] . The short interfering RNA [wikipedia.org] molecules are fragile. The article is touting a potentially more effective delivery system (gun), rather than a particular fragment (bullet).

Re:What's being 'silenced' here? (1)

RabidReindeer (2625839) | about a year ago | (#43810997)

The idea is to down-regulate the production of protein(s) that induce cellular senescence in chronic wounds, for example [nature.com] . The short interfering RNA [wikipedia.org] molecules are fragile. The article is touting a potentially more effective delivery system (gun), rather than a particular fragment (bullet).

An even better system would also deal with the fallout from flesh-eating bacteria!

Re:What's being 'silenced' here? (1)

waterbear (190559) | about a year ago | (#43820199)

TrashGod wrote:
> The article is touting a potentially more effective delivery system (gun), rather than a particular fragment (bullet).

Yes, that looks like a fair assessment. But the story as posted and linked is still essentially incomplete, because it doesn't mention what useful thing they propose to deliver. There has to be some beneficial payload in order to make this delivery system any use at all, assuming of course that it works as a delivery system.

The possible example of a 'payload' that you mention (not mentioned in the original article or links), for which you provided a separate link, is of something to down-regulate the production of protein(s) that induce cellular senescence in chronic wounds. This looks as if it could even be actually harmful if added to a wound, because the article you linked explains that the (natural) induction of this senescence restricts fibrosis in wound-healing. But, fibrosis "can be defined as the replacement of the normal structural elements of the tissue by distorted, non-functional and excessive accumulation of scar tissue" and gives rise to "many clinical problems" http://www.math.pitt.edu/~cbsg/Materials/Wound_Healing_Overview.pdf [pitt.edu] (such as keloids, hypertrophic scars, strictures and a whole list of problems). Thus, downregulating this senescence-inducing protein would be expected to increase the level of fibrosis in the healing wound, and to increase those problems: a harm, not a benefit.

There are plenty of technical 'solutions' around that might be wonderful if there was actually a problem of the right shape for them to solve -- read: they are of no real use because there is no useful application for what they might do. As pure science this one may have interest, but as a useful product, there's no sign here of that.

Typo in title (0)

Anonymous Coward | about a year ago | (#43810755)

BandageS ... encourage -there shouldn't be an S in 'encourage'

Can I borrow that? (0)

Anonymous Coward | about a year ago | (#43810925)

Fortunately there is absolutely no chance of other infections (In a wound? How absurd!) developing resistance and start hip-hopping and exchanging it about. Or picking up the repressors and passing them on to, say ....
No. The invisible hand of funding and profit-spinning will see to it. You must have faith, in these things.

So... (1)

Impy the Impiuos Imp (442658) | about a year ago | (#43811027)

I thought chronic, poorly-healing wounds were due to poor blood flow. Diabetes wrecks small blood vessels like capillaries, or unconscious people getting bedsores at pressure points.

This is spectacular. (4, Insightful)

bmo (77928) | about a year ago | (#43811115)

Foot ulcers in diabetics and bed sores in the elderly are really hard to deal with. Even when blood sugar is under control, these things take a long time to heal. You don't ever want one to happen to you.

Slapping a specially treated bandage on a wound can *genetically* encourage healing? This is tantamount to finding out that you can cure scurvy with vitamin C to the affected people.

--
BMO

Re:This is spectacular. (0)

Anonymous Coward | about a year ago | (#43813471)

Next time try raw honey. It works wonders.

Re:This is spectacular. (0)

Anonymous Coward | about a year ago | (#43815841)

>Next time try raw honey. It works wonders.

At spreading botulism.

Amazing (1)

carrier lost (222597) | about a year ago | (#43812143)

I thought of this image [botaday.com] a couple of days ago, finished it last night.

This seems to happen every few weeks: I draw something that relates in some weird way to some current event I had no previous idea of.

I've tagged these images as "psychic [botaday.com] ", for want of a better term.

Anyway, I apologize for hijacking the conversation - couldn't help myself. As you were.

This is a phenomenally bad idea.. (0)

Anonymous Coward | about a year ago | (#43812427)

The same type of scientists who assured us that Genetically modified genes wouldn't get into the food chain (they have) are now saying they can be trusted to know which genes to shut off and which ones not to to speed healing?

Thanks, but I'll trust billions of years of evolution over a few years of human arrogance and pursuit of the profit motive when it comes to wound healing.

And others have mentioned diabetics and the problems they have. Well they should know that Vitamin C speeds wound healing, so it would be highly effective on foot ulcers, wounds that won't heal, and bed sores. This has been know for centuries.

Not sure if you guys knew though.

Re:This is a phenomenally ignorant respose. (2)

conspirator23 (207097) | about a year ago | (#43814737)

Congratulatons, you have managed to parlay your irrational fear of GMO into an irrational fear of entirely unrelated technologies. There's no gene splicing going on here. The RNA material they are embedding into the bandage are not genes, are not being spliced into living cells, and will not replicate. They are basically custom marching orders being sent to the existing genes, temporarily telling certain ones to shut the hell up for the duration of time that the RNA persists in the immediate area. The bandage approach is specifically because the RNA is so fragile as to not deliver effectively via traditional methods. So... you're wrong on so many levels, it boggles the mind.

Welcome to Slashdot, BTW. You fit in just fine.

Re:This is a phenomenally ignorant respose. (0)

Anonymous Coward | about a year ago | (#43818253)

I agree. Your response *is* phenomenally ignorant. And, overweeningly arrogant. And replicates the drivel and trope that have been used to foist hasty death on humanity, in the name of fame, power, and a quick buck (not necessarily in that order) millenia since the buck was invented, or before drinking radium tonic, using asbestos, lead makeup, leadedgas,and ... well, it's a huge list. Penicillin *was* great, wasn't it? So were CFC's. So was DDT. So was nuclear energy. So was gunpowder assisted coal mining. And, strip mining. Whose discouyrse you mimic [imdb.com] , socially.

Psoriasis? (0)

Anonymous Coward | about a year ago | (#43813475)

Looking forward to a patch that I can apply to really bad areas of psoriasis to turn the damned switch off.

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