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Cells Reprogrammed In Living Mice

Soulskill posted about a year ago | from the turn-your-excess-bodyfat-into-brain-cells dept.

Biotech 29

sciencehabit writes "Researchers have discovered a surprisingly effective way to 'reprogram' mature mouse cells into an embryolike state, able to become any of the body's cell types (abstract). Their recipe: Let the transformation happen in a living animal instead of a petri dish. The finding could help scientists better understand how reprogramming works and it may one day help breed replacement tissues or organs in the lab—or in living patients."

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Reprogramming Mice (4, Funny)

rossdee (243626) | about a year ago | (#44822907)

Is this a Logitech advertisement?

To you and everyone below you.... (-1)

Anonymous Coward | about a year ago | (#44823355)

bored now.

You offer nothing.

Just a bunch of typical internet morons.

Why do I come here?

I'M going away now.

Nothing but sheeple - all of you.

Lame ass arguments that I've heard a xillion times before and on rare occasions, an argument I've read before.


Typical Human Lemming Lamoes - all of you.

You think you are soo smart.

On ocaasion I USED to get some really useful information - you know experts.

They're gone now. I guess moved on to better things.

You are all losers. You now that? Losers who are reading shit from Slashot's masters. And you are too stupid to see it.

Too stupid to see how you're being manipulated.

I see stupid people - and it's you!

Re:To you and everyone below you.... (2)

krashnburn200 (1031132) | about a year ago | (#44825409)

Wow kudos for the effort. You are the most prolific whiny bitch I have seen all week.

Re:To you and everyone below you.... (0)

Anonymous Coward | about a year ago | (#44915435)

He/she has a few points though:
- fairly obvious massaging of the news stream to get stuff off the front page.
- fairly obvious sockpuppet pieces.
- fairly obvious targeted tests

To me this makes /. somewhat interesting but in a different way than it's "supposed to be".

If you haven't noticed try using the rss feed and let it simmer for a while while keeping an eye on it until you have lt's say a hundred items, then look for hat seems like patterns and then actually open the stories according to individual patterns and look closer at what's going on.

Re:To you and everyone below you.... (0)

Anonymous Coward | about a year ago | (#44826377)

weak - if you're gonna troll - at least learn to make it slightly interesting

- this guy make me miss the "Fix My PC" spam (or what ever the F that was...)

Why do I come here?

who the f knows. pls go away

Re:Reprogramming Mice (0)

Anonymous Coward | about a year ago | (#44827695)

No, it is about downsized engineers working on PS3 software from inside living mice. God I miss LSD...

Now this is great news (2)

houbou (1097327) | about a year ago | (#44822929)

Morphing cells, so, this can have the amazing implication of fixing pretty much anything, if not enhancing and/or even modifying your cells.. Can this help with aging?

Re:Now this is great news (2)

Lohrno (670867) | about a year ago | (#44823185)

I'm not a scientist, so my comment here is possibly worthless - but.. If they could reprogram them to be fresh stem cells - yes probably.

Re:Now this is great news (1)

Flere Imsaho (786612) | about a year ago | (#44824177)

In my (mostly) uninformed opinion, it depends if the cells telomeres are extended, and I doubt they would be. This could conceivably be used to regrow organs, but they would have the same genetic "age" as the original cells.

Re:Now this is great news (1)

houbou (1097327) | about a year ago | (#44825593)

Still, if the age and quality are not one and the same being that an old organ would behave as a new one..

Re:Now this is great news (1)

Flere Imsaho (786612) | about a year ago | (#44826881)

True. You'd basically get an organ comprised of new, fresh cells, even if they have the same genetic age as the original organ. But if you continued replacing organs in this manner, eventually short telomeres would start intruducing errors.

I did a bit more reading, and telomerase is active in stem cells, so potentially you could change cells to stem cells and then make them differentiate into normal cells again? TFA does state they can reprogram to any cell type.

Re:Now this is great news (0)

Anonymous Coward | about a year ago | (#44827025)

And yet, two thirty year old people can make a zero year old baby with zero year old organs in it. Seems to me we really need to explore this biological complexity...

Re:Now this is great news (0)

Anonymous Coward | about a year ago | (#44827757)

That's because your gonads, unlike all other cells, can extend their telomeres. As can cancer cells.
Actually I guess the danger of cancer is the main reason why the cells are programmed to die. It is another hurdle for a cell to overcome before it becomes a cancer cell. It doesn't help the organism one bit if it could theoretically live forever, but in practice is killed off by cancer quite early. Better to die from ageing after 80 years, than to die of cancer after 8 years.

Re:Now this is great news (0)

Anonymous Coward | about a year ago | (#44828023)

Screw that noise! Will it give me a bigger penis?

Half novel, half obvious (0)

Anonymous Coward | about a year ago | (#44822955)

Their recipe: Let the transformation happen in a living animal instead of a petri dish.

I was under the impression that it is fairly common knowledge that cells from multicellular animals have difficulty surviving (and even more difficulty behaving) when not in such an animal. Maybe I only remembered the cases where attempted cell cultures from [test animal] failed to survive at all in dishes.

I can see why this sort of test is not the first choice, science is cleaner the fewer unknown variables are involved. On the other hand, biochemistry is very complex, and I'm not exactly surprised that some of these experiments work when in the setting of a living animal even if they cannot in a controlled environment.

My conclusion: Good progress, keep testing, and try not to make tumors.

Re:Half novel, half obvious (2, Funny)

i kan reed (749298) | about a year ago | (#44823155)

We'll just reprogram the tumors to be extra testicles. Even in women. Problem solved.

Re:Half novel, half obvious (1)

drkim (1559875) | about a year ago | (#44826393)

We'll just reprogram the tumors to be extra testicles. Even in women. Problem solved.

Yeah, "Problem solved" 'til you get your hand up her dress and..... "uh oh!"

Turn your excess bodyfat into brain cells dept (1)

sobolwolf (1084585) | about a year ago | (#44823077)

For anyone that didn't read the slogan.... Soulskill has definitely out done himself today! Kudos!

Now we can create (1, Interesting)

geekoid (135745) | about a year ago | (#44823101)

personal save points and roll back as needed!

Re:Now we can create (1)

game kid (805301) | about a year ago | (#44823145)

As if Linus needs another reminder about the SSD.

Re:Now we can create (1, Offtopic)

geekoid (135745) | about a year ago | (#44823217)


Old man dying on bed
Dr. "What do you mean you never bothered to back up? Every always needs to back up!"
Camera Zooms in on old man... It's Linus.

Re:Now we can create (2)

compro01 (777531) | about a year ago | (#44823319)

Only wimps use backups: real men just upload their important stuff on ftp, and let the rest of the world mirror it.

Re:Now we can create (1)

You're All Wrong (573825) | about a year ago | (#44824575)

And after he dies, several thousand people make a claim to his estate...

Regeneration (2)

vigmeister (1112659) | about a year ago | (#44823209)

Could be messy, but ultimately, would a 'rolling regeneration' of our organs conveniently sidestep cellular senescence? Can you hear me now?

The end of the fitness industry (1)

Jah-Wren Ryel (80510) | about a year ago | (#44824693)

If they can figure out how to reprogram fat cells to be muscle cells, we can eat McD's for an entire month end up looking like Arnold Schwarzenegger.

a stepping stone to.. (2)

houbou (1097327) | about a year ago | (#44825737)

true regeneration. It's that simple. If you can literally reprogram your cells, then you can use this for maintenance and/or repairs. Certainly this can mean cutting to the quick when it comes to issues such as aging. This is literally a gold mine. If such knowledge can become applied in a practical way, this can become real preventive medicine. It would have the ability to halt aging. It would also have the ability to regenerate any part of us we have, thus eliminate the need for organ donors. As long as the human brain is well, this could more than likely make us rethink our entire way we deal with medicine. This can become a big deal.

Re:a stepping stone to.. (1)

abies (607076) | about a year ago | (#44828629)

Unfortunately, this will not help against cancer, which is quite common cause of death these days. And I have a feeling that getting stem cells running crazy in your body is going to produce whole new set of cancer possibilities.

Reminds me of radical regeneratives from []

Re:a stepping stone to.. (0)

Anonymous Coward | about a year ago | (#44842503)

Literally a gold mine.


Transformers (0)

Anonymous Coward | about a year ago | (#44826017)

More than meets the eye!

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