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Scientists Reverse Muscle Aging In Mice

Soulskill posted about 4 months ago | from the mighty-mouse-will-return dept.

Medicine 34

retroworks sends word that a group of researchers has found a chemical that successfully rejuvenated muscle tissue in mice. The scientists "said it was the equivalent of transforming a 60-year-old's muscle to that of a 20-year-old — but muscle strength did not improve." The study (abstract) is being called an "exciting finding" but the researchers are quick to point out the chemical only reverses one aspect of aging. Damage to DNA and shortening of telomeres continues. Still, it's one piece of the puzzle, and the group is hoping to begin clinical trials in 2015.

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34 comments

Huh? (4, Interesting)

Anonymous Coward | about 4 months ago | (#45749521)

DNA and telomere damage continues, and muscle strength does not improve. So what exactly makes this the equivalent of 20 year old's muscles? An affinity for beer and an overwhelming urge to chase women around?

Re:Huh? (4, Informative)

Trepidity (597) | about 4 months ago | (#45749651)

From the summary, it seems they're specifically looking at the decline in mitochondrial function that accompanies aging. There's already known [biologists.org] to be such a relationship, and the study linked here is claiming that increasing the levels of something claimed NAD+ [wikipedia.org] in the muscular tissue of mice appears to reverse the decline in mitochondrial function.

Re:Huh? (3, Informative)

Anonymous Coward | about 4 months ago | (#45749795)

This isn't really novel since the SIRTUIN/NAD+/Resveratrol story has been know for sometime. Activation of Sir2 in yeast by resveratrol extended lifespan(guarente et al).

Re: Huh? (1)

Anonymous Coward | about 4 months ago | (#45749833)

It's been known for a while that NAD is beneficial - what they seem to have achieved here is find something that increases the amount in the tissue. They are using something called NMN to do this but appear to be using massive doses that are injected.

Diabetes type 2 (0)

Anonymous Coward | about 4 months ago | (#45752929)

So basically it is boosting muscle cell metabolism rate to youth level. I wonder if it would reverse the glucose intolerance and cure diabetes type 2?

Re:Huh? (1)

iamnotasmurf (3464141) | about 4 months ago | (#45749745)

i drank a lot of beer and i chased a women home last night.and now im in a police cell. last time ill take part in a cretin advertising campaign!

Re:Huh? (2)

ackthpt (218170) | about 4 months ago | (#45749859)

DNA and telomere damage continues, and muscle strength does not improve. So what exactly makes this the equivalent of 20 year old's muscles? An affinity for beer and an overwhelming urge to chase women around?

Don't forget the urge to drive monster trucks.

Re: Huh? (0)

Anonymous Coward | about 4 months ago | (#45749903)

I'd be quite happy with that...

Re:Huh? (0)

Anonymous Coward | about 4 months ago | (#45749955)

It's a start, it's a refreshing balance to the usual space fanboyism that's all too common on tech sites.

movie (0)

Anonymous Coward | about 4 months ago | (#45749639)

I've seen the end to this movie... http://www.imdb.com/title/tt0120804

Re:movie (1)

erikkemperman (252014) | about 4 months ago | (#45749873)

For an interesting and entertaining extrapolation of a planet without death, I recommend Torchwood: Miracle Day. (British scifi, spun off of Doctor Who, but rather more grim and dark and gory.

Re:movie (0)

Anonymous Coward | about 4 months ago | (#45750545)

seen it. was just being snarky....

Left out some details? (2, Funny)

Anonymous Coward | about 4 months ago | (#45749641)

Yes, but more importantly, how does that affect the flavor of the mice?

Dont bank on it yet -- GSK did (1)

Yergle143 (848772) | about 4 months ago | (#45749701)

The lead author, David Sinclair, has pursued some very interesting hypothesis. This work dovetails into his findings about resveratrol. The trouble is that there has been a mixed record, to say the least, in others (Amgen and Pfizer) reproducing his work:
Still you never know, so I'm mixing up a nice resveratrol NAD+ cocktail. [scientificamerican.com]

Re: Dont bank on it yet -- GSK did (-1)

Anonymous Coward | about 4 months ago | (#45749801)

He is not the lead author - just the one with the loudest mouth prone to exaggeration.

Dementia and strength (0)

Anonymous Coward | about 4 months ago | (#45749821)

There's a whole lot of alzheimer's patients out there that are only manageable by family members because of their limited mobility. This research sounds exciting, but all the same, it makes me wonder if there may be problems caring for mentally damaged, but physically fit elders.

NAD(H) (2, Interesting)

Anonymous Coward | about 4 months ago | (#45749829)

Bodybuilders have been using this for a while now...

Great! (1)

CHIT2ME (2667601) | about 4 months ago | (#45749961)

Great! Now we're going to have 90 year old body builders at the gym who can't remember where the are or why they are there!

"You are not ready for immortality." (2)

mmell (832646) | about 4 months ago | (#45750059)

*turns, leaves room*

Re:"You are not ready for immortality." (0)

Anonymous Coward | about 4 months ago | (#45766187)

*turns, leaves room*

Nice Babylon 5 reference.

Frozen MidWest (1)

StewBaby2005 (883886) | about 4 months ago | (#45750463)

This 61 year old would love to have 20 something muscles after shovelling snow for the last week here in the frozen MidWest! :)

WHAT chemical: (1)

Ungrounded Lightning (62228) | about 4 months ago | (#45750713)

From TFA:

Experiments showed that boosting NAD levels, by giving mice a chemical which they naturally convert into NAD,

The chemical used in the study is not mentioned in the linked abstract, either.

Does anyone know what the chemical, and dosage, in question might be?

Re:WHAT chemical: (0)

Anonymous Coward | about 4 months ago | (#45761975)

Yeah, it's in the methods though:

"The NMNAT1 plasmid was a kind gift From Professor Toshiyuki Araki (National Center of Neurology and Psychiatry, Japan) and was generated by cloning mouse NMNAT1 cDNA with a C-terminal 6xHis-Tag into the BamH1 site of a pIRES-eGFP plasmid (Clonetech). The plasmid was purified using endotoxin-free Maxi-Prep Kit (QIAGEN) and resuspended in sterile 0.9% saline. Mice were anaesthetized, their hind limbs shaved and wiped with ethanol. Hyaluronidase (15 units in 50 l saline) was injected into the tibialis cranialis muscle transcutaneously along the length of the muscle using an insulin syringe. Following a 1.5 hr waiting period, plasmid (50 g in 50 l saline) was injected along the complete length of one tibialis muscle. This was followed by eight pulses of 100 V/cm and 20 msec at a frequency of 1 Hz via tweezer electrodes attached to an ECM-830 electroporator (BTX). For each mouse, the contralateral muscle received an equal volume saline and underwent the electroporation protocol, to act as an internal control. Mice were sacrificed 7 days following electroporation and both tibialis muscles were collected for subsequent analyses. Animal experiments followed the guidelines and were approved by the Garvan Institute, Australia."

I welcome our young mice overlords... (1)

ignavus (213578) | about 4 months ago | (#45751605)

It's no wonder that mice are so successful as a species. We put so much effort into making them healthier.

Now we are giving them the elixir of youth as well.

Obligatory comic reference (0)

Anonymous Coward | about 4 months ago | (#45752999)

http://www.smbc-comics.com/index.php?db=comics&id=2881

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