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Mimicking Vesicle Fusion To Make Gold Nanoparticles Easily Penetrate Cells

Unknown Lamer posted about 6 months ago | from the golden-hypospray dept.

Medicine 20

rtoz (2530056) writes A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. MIT engineers created simulations of how a gold nanoparticle coated with special molecules can penetrate a membrane. Paper (abstract; full text paywalled).

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Hmmm (-1)

Anonymous Coward | about 6 months ago | (#47504291)

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(Sing to Can-Can dance)


plating effect (2)

jblues (1703158) | about 6 months ago | (#47504337)

As folks who've experimented with the anti-biotic and anti-viral effects of silver can attest, its important that we do indeed start with nano-particles. Bigger particles tend to have a plating effect and tattoo under the skin: https://www.youtube.com/watch?... [youtube.com]

Particles are baloney (1)

toQDuj (806112) | about 6 months ago | (#47504365)

Except that the stripy particles used here are not real. Stellacci has been claiming to make these, but there are big doubts over the evidence:
http://www.timeshighereducatio... [timeshighe...tion.co.uk]

Re:Particles are baloney (3, Informative)

toQDuj (806112) | about 6 months ago | (#47504381)

Additional links: A big discussion has taken place on PubPeer following a pre-publication arXiv release of a paper (full disclosure: I'm a co-author on the second version of this paper). The paper is well worth a read, and should be coming out soon in PLoS One.

ArXiv: http://arxiv.org/abs/1312.6812 [arxiv.org]
Pubpeer: https://pubpeer.com/publicatio... [pubpeer.com]

Re:Particles are baloney (1)

sribe (304414) | about 6 months ago | (#47504393)

Oh come on, man! Did you even read that article? The person questioning him is Prof. Moriarity! Once an evil villain, always an evil villain!

Re:Particles are baloney (1)

toQDuj (806112) | about 6 months ago | (#47504417)

Actually, I've been working with Prof. Moriarty and he's great fun. He has some "sixty symbols" and "numberphile" videos up on youtube if you are interested.

Re:Particles are baloney (1)

Badge 17 (613974) | about 6 months ago | (#47504841)

Taking a look at the paper, it doesn't appear that these results are highly dependent on the striped morphology, which, I agree, is dubious. These guys aren't using that, they're claiming a "checkerboard" shape.

I haven't read through the whole literature on this - are *all* of the patterns crap? Are there checkerboards, or just noise + STM artifacts?

Re:Particles are baloney (0)

Anonymous Coward | about 6 months ago | (#47504933)

The measurements in the earlier 2004-2008 publications very much suffered from feedback artefacts. The later measurements showed these stripy features less and less. However, as they were convinced the features had to be there, they started seeing spots that were purportedly aligned in stripe-like domains. SPM was the main technique used for this investigation. Other techniques such as NMR and SANS showed evidence for a phase-separated structure, but did not provide evidence for stripy domains.

Re:Particles are baloney (0)

Anonymous Coward | about 6 months ago | (#47508175)

Thanks for the info!

- Paul [vihjemedia.com]

I had to read that title 3 times (1)

viperidaenz (2515578) | about 6 months ago | (#47504405)

First it looked like Vehicle Fusion, then Testicle Fusion.

Re:I had to read that title 3 times (0)

Anonymous Coward | about 6 months ago | (#47504433)


Re:I had to read that title 3 times (0)

Anonymous Coward | about 6 months ago | (#47504787)

First it looked like Vehicle Fusion, then Testicle Fusion.

Interesting. What do you think this looks like: y0r3 m0m h45 t35t1c135

DRM'd academic papers... wow (0)

Anonymous Coward | about 6 months ago | (#47504443)

I guess I just don't read Nature Communications much, but does anybody else have any experience with this Readcube bullshit? My university just cancelled their Nature Group subscription and replaced it with this... Adobe Flash dependent "rental" of academic papers.

Finally, a cure for the common cold... (0)

Anonymous Coward | about 6 months ago | (#47504597)

...sore, that is!

wake me (0)

Anonymous Coward | about 6 months ago | (#47504921)

when they get more energy out than they put in

If it's fake have at least a laugh. (0)

Anonymous Coward | about 6 months ago | (#47505045)

some gold jokes:

Hello, Ginger! Her brother called cheerily to his sister.
Dont call me Ginger! she snapped furiously. My hair is the color of gold.
Yeah, he replied with a jeer, twenty-four carrots!

An elderly woman decided to have her portrait painted. She told the artist Paint me with diamond earrings, a diamond and gold necklace, emerald and gold bracelets, a ruby broach, and gold Rolex." "But you are not wearing any of those things" replied the artist.
"I know," she said. "It's in case I should die before my husband. I'm sure he will remarry right away, and I want his new wife to go crazy looking for the jewelry."

Bill: Where did you get that gold watch Joe?
Joe: I won it in a race.
Bill: How many people participated in it?
Joe: Three, a policeman, the owner of the watch, and me!!

Urgh (1)

wonkey_monkey (2592601) | about 6 months ago | (#47505895)

Mimicking Vesicle Fusion To Make Gold Nanoparticles Easily Penetrate Cells

I've no idea what that means but I feel dirty after reading it.

Editors? (0)

Anonymous Coward | about 6 months ago | (#47506257)

Why is this on Slashdot (I can understand why it would be on MIT News when some of the researchers are from MIT)? I work in the field and would describe what was done in the paper as routine and in no way groundbraking. It does present a new insight into the matter of gold particle intake and relate this to the model vesicle fusion mechanism, which is nice (although of not so much relevance in biology, as the fusion there is usually an active process driven by SNARE proteins and such; similarly nanoparticle intake does not in vivo happen merely through passive diffusion). I am in no way calling the work bad or undeserving, I simply am surprised as to why it would be reported in the mainstream media (if /. can be counted as such), as they did not showcase any working applications or anything that might be interesting even from a technological point of view (the simulations done here are not unprecedented in scale requiring huge computers; sure you need a cluster, but nothing even from TOP500).

Will it be a reality? (0)

Anonymous Coward | about 6 months ago | (#47507513)

Gold pressed latinum, one step closer.

It's been done (1)

Sir Holo (531007) | about 6 months ago | (#47529395)

It's been done already. [nature.com] Open access.

That is, non-toxic transfection and organelle targeting of a combination "marker & delivery vehicle" into live cells, confirmed by both optical and electron imaging. Special nanodiamonds in this case.

(Full disclosure: It was me.)
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