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Longer Lasting Caffeine

michael posted more than 12 years ago | from the good-to-the-last-drop dept.

Science 51

falser writes "Caffeine addicted geeks everywhere may rejoice that scientists have discovered a protein that appears to be responsible for amplifying the caffeine buzz. It also makes the effects last longer. Just one question: how soon until we have a new generation of ultra powerful caffeine products?"

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Rock Star (-1, Flamebait)

Anonymous Coward | more than 12 years ago | (#4076117)

It has 16oz of hyper-caffiene goodness (as well as ginseng and whatever else) and will KICK YOUR ASS.

the come-down is a BITCH, tho.

oh, and FP for GOATSE.MAN!

SP (-1, Troll)

Anonymous Coward | more than 12 years ago | (#4076130)

Second Post too!

Rock on austria!

How soon indeed. (0)

Anonymous Coward | more than 12 years ago | (#4076136)

How soon until ThinkGeek starts selling Yet Another Overpriced Caffeine Product that's really about as effective as a cup of coffee and of dubious health impact. I can't wait to see the big fucking banner ads.

Re:How soon indeed. (0)

Anonymous Coward | more than 12 years ago | (#4076149)

Fuck ThinkGeek; I get all mine from the liquor store.

More caffiene; and less waiting.

Re:How soon indeed. (0)

Anonymous Coward | more than 12 years ago | (#4076178)

Why the fuck are you buying caffeine at the liquor store?

Booze? All you need is some knob creek and some saffire.

Re:How soon indeed. (0)

Anonymous Coward | more than 12 years ago | (#4076196)

I don't drink; the liquor store just happens to be next door (I chose the apartment back when I used to drink)

A five minute walk still beats a next-day delivery. ;)

TP! (-1, Troll)

Anonymous Coward | more than 12 years ago | (#4076140)

Toilet Paper.

WIPO Your ASSO!

FP finally! (0)

Anonymous Coward | more than 12 years ago | (#4076176)

except I can't be bothered to read the article. :(

Please Read the Article (5, Informative)

Mick D. (89018) | more than 12 years ago | (#4076194)

The Chemical they are talking about (DARPP-32) is what makes as long lasting as it is in humans and mice. We already have it in our brains and it creates a positive feedback mechanism that keeps the stimulating effects of caffeine going.

The mice without DARPP-32 reacted very minimally to ~6 cups of coffee worth of caffeine.

In Other News... (2)

Vinson Massif (88315) | more than 12 years ago | (#4077198)

Today, Starbucks(SBUX) announced a $10 million dollar research grant prgram to alleviate the effects of the 'caffeine protein', DARPP-32, on the population.

"We believe our customers are impeded from the full experience of our product by this deleterious, evil protein." an unamed spokesman said.

"Our customers are asking for this." he continued, "It's the least we can do. That and make sure we have another super-grande-lofat-mocha-latte-ice" ready and waiting for them."

Re:Please Read the Article (2)

Oztun (111934) | more than 12 years ago | (#4082490)

Yeah but the real question is - How many times does a rat need to pee before he finishes of six cups of coffee?

Yeah yeah I know sex cups of coffee worth of caffeine bleh bleh.

Hyper-caffeinated products? (3, Interesting)

evalhalla (581819) | more than 12 years ago | (#4076308)

From the article it seems that the proteine is already in the human (or mice's) brain, and that it prolonges the effect of caffeine, but the effect of adding such proteine in the body directly aren't clear. Maybe it has more or less the same effect of caffeine, maybe if you take it together with caffeine the body feels that there is already enough of it and you have the (gulp!) opposite effect. So one of the few researchs that could have helped caffeine-addicted people ends helping those sad "decaffeinated" people out there, and this is not good. :)

Me, I'll just stick to real coffee and use chocolate to enhance the effect of caffeine.

By the way, I wonder whether the big number of people in favour of "caffeinated" as opposed do "decaffeinated" in the pool has something to do with people from slashdot. :)

Its called meth (0)

Anonymous Coward | more than 12 years ago | (#4076385)

Excites the production of the same protien.

It's too big a molecule... (4, Insightful)

Peter T Ermit (577444) | more than 12 years ago | (#4076397)

A 32,000-dalton protein tends to get digested rather than passing directly into the protein, so you'd have to administer it intravenously. And then it has to get past the blood-brain barrier. Even if you got it directly into the brain it's far from obvious that it would have the effect you like.

Sorry, no Jolt++ for you.

er... passing directly into the bloodstream. (1)

Peter T Ermit (577444) | more than 12 years ago | (#4076448)

That's what I meant.

Re:er... passing directly into the bloodstream. (0)

Anonymous Coward | more than 12 years ago | (#4076482)

it appears you had it right the first time. At least according to him.

Re:It's too big a molecule... (2)

g4dget (579145) | more than 12 years ago | (#4076911)

That's easy: inject the DNA into brain cells with a gene gun and drink lots of coffee :-)

HEY! THAT'S DECAF!!! (0)

Anonymous Coward | more than 12 years ago | (#4076524)

Isn't green traditionally used to indicate decaffeinated coffee? Check out the image in the CNN story. ;)

So THAT'S why coffee has so little effect on me (5, Interesting)

renehollan (138013) | more than 12 years ago | (#4076534)

I have to drink massive quantities of strong coffee to feel anything. It's effect on me is mostly psychological: "... ah, that first cup of warm coffee in the morning shakes off the cold of getting out of bed..." ('course I now live in Texas, where it can be 95F at 6:00AM, but you get the idea).

Perhaps I have a genetic mutation that causes this protein to not be present. Researchers also said that it may play a role in enhancing the effects of cocaine and amphetemines. If coke's reputation weren't so dangerous, it might be worth snorting a small line to see if I was immune to that too (though I do not indulge in illicit drugs for recreational purposes). Of course the U.S.'s "War on Drugs" makes such research practically impossible. Perhaps people with an excess of this protein are more likely to become addicted to coke. Certainly formal research in this area might go a long way toward understanding the chemical basis for certain drug addictions.

Re:So THAT'S why coffee has so little effect on me (0)

Anonymous Coward | more than 12 years ago | (#4077299)

Or maybe you have just built up a tolerancy against caffeine :P

Re:So THAT'S why coffee has so little effect on me (2)

renehollan (138013) | more than 12 years ago | (#4077387)

Or maybe you have just built up a tolerancy against caffeine.

I don't think so. I remember a doctor prescribing a cup of coffee to calm me down after overactive play as a child, saying that it has a depressive effect for some (this was before the whole ADD/ADHD hoopla) -- my parents wanted a child that was seen, but not heard.

Re:So THAT'S why coffee has so little effect on me (0, Flamebait)

catwh0re (540371) | more than 12 years ago | (#4081425)

So THAT'S why coffee has so little effect on me

and here i was thinking that he was going to say "if i had a brain i too could experience coffee buzz"

Did you actually bother to READ the articul? (0)

Anonymous Coward | more than 12 years ago | (#4076678)

Damn! I can't believe how someone can blatantly miss the point like that. Moderators...you know what to do!

Why aren't there any caffiene patches? (3, Insightful)

kiick (102190) | more than 12 years ago | (#4076830)

Wouldn't it be really convenient to just slap on a caffiene patch in the morning and forget about it? I'm sure there are times when, for whatever reasons (medical, maybe) drinking lots of coffee/coke is not advisable. We need a patch!

Re:Why aren't there any caffiene patches? (3, Informative)

dreamchaser (49529) | more than 12 years ago | (#4076863)

There are, you just can't buy them anywhere. Several hosptials are testing them as a means of helping people shake off the foggy after effects of anasthesia faster.

Re:Why aren't there any caffiene patches? (1)

reyalsnogard (595701) | more than 12 years ago | (#4076927)

Hopefully they'll be able to deduce whether caffeine acts as a stimulant or depressant for the client before slapping on a patch .. I'm one of the 'lucky few' who feels oddly sedated after consuming a measurable quantity of caffeine.

Re:Why aren't there any caffiene patches? (2)

r00tarded (553054) | more than 12 years ago | (#4076919)

sigh, no coke in the server room.

Re:Why aren't there any caffiene patches? (1)

RevDobbs (313888) | more than 12 years ago | (#4081040)

isn't that the DEA's fault?

Re:Why aren't there any caffiene patches? (0)

Anonymous Coward | more than 12 years ago | (#4078669)

You can get caffine pills which are very convenient. See this comparison chart [erowid.org] of various brands. An ex-girlfriend used to pop a couple of them before going to work after a night of no sleep.

Caffeinated Water (1)

Shook (75517) | more than 12 years ago | (#4082342)

There are brands of caffeinated water. While it wouldn't have the long-lasting effect of a patch, it could skip some of the problems with coffee and cola.

Water Joe [waterjoe.com] comes to mind.

Make the leap (3, Funny)

Hoi Polloi (522990) | more than 12 years ago | (#4076949)

I've already switched to methamphetamines!

Re:Make the leap (0)

Anonymous Coward | more than 12 years ago | (#4078654)

Good job, funny-man. Keep that up and you'll be experiencing permanent brain damage and psychotic episodes in no time.

Re:Make the leap (0)

Anonymous Coward | more than 12 years ago | (#4080848)

Yep.

I know tons of kids in college using adderall or ritalin to get them through their classes.

There are very few people who aren't helped by these "uppers."

Emphetamines have been in use a long time and in controlled amounts are a great help to get through a long coding or study session.

It's no different from "NoDoze" or whatever except the chemical is different.

-d

Re:Make the leap (0)

Anonymous Coward | more than 12 years ago | (#4083182)

It's also great if you need to drop a few pounds.

Ride the snake!

interesting, this might explain why some people... (1)

f00zbll (526151) | more than 12 years ago | (#4077060)

aren't affected by caffiene. I used to drink a tall glass (16oz) coke or coffee before going to bed. People used to look at me like I'm crazy, asking me "How can I sleep with that much caffiene?" It might be that those people don't have the protein. Could be an interesting research topic.

Re:interesting, this might explain why some people (0)

Anonymous Coward | more than 12 years ago | (#4078958)

Could be tolerance....
When I'm in caffeine addict mode, I have to slam a couple RedBulls before bed just so I don't get a headache.

Caffeine withdrawl headaches are NASTY.

Hmm. RedBull is banned in B.C. it seems. Couldn't find any anywhere.

Re:interesting, this might explain why some people (2)

tomhudson (43916) | more than 12 years ago | (#4082522)

re: could be tolerance


could also be a big bladder.

i wonder... (0)

Anonymous Coward | more than 12 years ago | (#4077128)

i wonder if any supercaffeinated products will be legal here in Sweden. There seems to be some restrictions to these things over here. Red Bull, for example, is allowed here due to an exception.

HyperCaffeine? (2, Funny)

Anonymous Coward | more than 12 years ago | (#4077544)

IIIIII'''vvvveeeee tttrrriiieeeddd iiittt.... IIII rrrreeeeeallllyyy ddddiiiinnn'''tttt fffffeeeelll aaaaannnnyyy eeeeffffeeeccccttttssss.......

More, better caffiene. (1)

Valar (167606) | more than 12 years ago | (#4078457)

This is *twitch* exactly what I *twitch* need. My *jerk, twitch* caffiene isn't strong *twitch, eyes roll back in head* strong enough. Now where did I put that 64 ounce coffee mug?

ahh the memories... (1)

JUSTONEMORELATTE (584508) | more than 12 years ago | (#4078635)

Now where did I put that 64 ounce coffee mug?
From alt.sysadmin.recovery, back when usenet was still really cool:
"I used to drink 6 cups of coffee in the morning and 6 in the afternoon.
This worried my cow orkers. Now I've cut down to 4.

Took me ages to find a cup that big"

L-Tyrosine is known to do this (3, Informative)

Deagol (323173) | more than 12 years ago | (#4078700)

A few years ago, I was researching the ACE "stack" (Asprin, Caffeine, and Ephedra). This is often used to either: a) loose weight; or b) increase effectiveness of strength training. L-Tyrosine is an amino acid which, when added to this mix (or caffeine alone), prolongs its effects and reduces the "jitters". So go visit your local health food store for similar stuff.

Never tried it myself, though.

Re:L-Tyrosine is known to do this (2)

Cy Guy (56083) | more than 12 years ago | (#4084498)

A few years ago, I was researching the ACE "stack" (Asprin, Caffeine, and Ephedra).

You don't by any chance work for the The Coffee Science Information Centre [cosic.org] , do you?

Yes, believe it or not, there is a research lab whose entire focus is the ebony elixir of life. The site has lots of interesting information such as information on caffiene [cosic.org] (FYI a 10 oz cup of drip coffee has nearly three times the caffiene of a 2 oz shot of expresso); The health benefits of coffee [cosic.org] ; and, a Coffee FAQ [cosic.org] .

Wonder if this protien is missing in Hyperactives? (0)

Anonymous Coward | more than 12 years ago | (#4078849)

Wonder if this protien is missing of mutated in people who are hyperactive. Two vivarin or a bottle of Jolt Cola and I'll be a sleep in about 10-15 min after it hits my bloodstream.

That's the odd thing about our body chemistry give us stimulants and we calm down. Kinda takes the fun out of caffeine.

Re:Wonder if this protien is missing in Hyperactiv (2)

ScottBob (244972) | more than 12 years ago | (#4081133)

Must be, I was a hyper child growing up in the 70's and I took ritalin up until the early 80's. Nowadays, I gots ta have my coffee in the morning, even though it has no effect on keeping me awake. I take a coffee break at work usually around 10 in the morning. I don't know why I even bother, because by 10:30 I fall asleep in my chair and damn near fall out of it. I've tried ritalin again recently, and sure, it does keep me awake, but then I would fall asleep rather suddenly instead of slowly dropping off like when I drink coffee. And I like to drink iced tea before going to bed, Mad River Oblong tea being one of my favorites. Except I have to get up and pee at 2 AM. But sleep aids usually have the opposite effect on me, they keep me awake.

Reason this thread only has 35 comments (2, Funny)

writertype (541679) | more than 12 years ago | (#4078973)

A thread about caffeine posted at 9:35 AM the last day of LinuxWorld...who's gonna be awake to read it?

Re:Reason this thread only has 35 comments (0)

RLiegh (247921) | more than 12 years ago | (#4080477)

No, the real reason is that this article never made it to page one; so right next to no-one saw it.

Obligatory South Park Reference (1)

Binome (589094) | more than 12 years ago | (#4079205)

HyperCaffeine!? Oh man! I can't take this kind of pressure!

Eat grapefruit. (4, Informative)

digitaltraveller (167469) | more than 12 years ago | (#4081551)

Seriously. The naringin in grapefruit prevents the breakdown of xanthines in the liver. The net effect is that certain pharmacological substances last longer. It works with other drugs too. It can conceivably contribute to OD-type situations as well. Also, as someone above said, the amino acid tyrosine also will potentiate the effects, as will other substances. Bodybuilders use this for dieting and have known about this for years. They are after all mostly walking lab experiments [bodybuilders.com]

Re:Eat grapefruit. (2)

jeff67 (318942) | more than 12 years ago | (#4082533)

Geeks with bad eating habits and good prescription drug plans should take note: Don't do this if you also take Lipitor [doctorsolve.com] to fight high cholesterol! Results can be very bad [s-t.com] .

Test, ignore (0)

Anonymous Coward | more than 12 years ago | (#4087971)

Just testing.

Check out my Canberra Aikido [aikido.org.au] site
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