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Hepatitis Drug Breakthrough

michael posted more than 11 years ago | from the magic-bullet dept.

Biotech 12

Lazyhound writes "The BBC reports that scientists at the University of Texas Southwestern Medical Center in Dallas are running clinical trials on a new drug (similar to those used to treat HIV patients) that can dramatically reduce levels of the virus in only days."

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C? (1)

4of12 (97621) | more than 11 years ago | (#5761307)

Does it work on Hep C?

Last I heard, there was no vaccine for that.

I traveled recently and got vaccinated for Hep A and B.

Re:C? (1)

Tropaios (244000) | more than 11 years ago | (#5761320)

Read the article, Hepatitis C Breakthrough...

Re:C? (2, Informative)

DogBarf (147635) | more than 11 years ago | (#5761328)

A vaccine would prevent contraction of the disease. This drug treats those who already have it.

Re:C? (2, Funny)

spotted_dolphin (595858) | more than 11 years ago | (#5762058)

'Breakthrough' may provide a clue as to what the article is referring to.

Re:C? (0)

Anonymous Coward | more than 11 years ago | (#5762388)

Wow. "C," huh? Well, I've got four more letters for you: R, T, F, and A!
(You first-posting karma whore...)

Nice! (0)

Anonymous Coward | more than 11 years ago | (#5761351)

The age of antiviral treatments is coming.

Does this affect the transmission of Hep C? (2, Interesting)

Tropaios (244000) | more than 11 years ago | (#5761391)

If the virus makes defective copies of itself is there a lessened chance of transmission? It seems they would still be a carrier of the disease but could they transmit it? If the virus is crippled and could not infect new cells it would seem contact with contaminated blood would be much less dangerous.

Re:Does this affect the transmission of Hep C? (4, Informative)

Muhammar (659468) | more than 11 years ago | (#5763509)

Viral protease inhibition: The giant protein chain synthetized for virus capside does not get cleaved into functional subunits as it is supposed to. So, since there are no functional viral proteins available - there is very little new viruses released and those released often are not infectious, because some important protens are missing from them.

There will be likelyhood of resistance development, but those resistant strains may be less infective - the viral protease has to be highly substrate specific (The giant protein chain has to be cleaved on certain specific spots and only there. So if it has to mutate, it may end-up to be less effective in doing its job.) This things has been already proven with HIV - except that HIV is too hard to eradicate completely and it is also an incredibly fast mutator, so some nasty mutant eventualy escapes. Hep C is nicer infection to treat.

Current Supply Impact (1)

SLASHDOT EDlTOR (589794) | more than 11 years ago | (#5761756)

This would enable a broader range of people doante blood. Interestingly, it is an anti viral agent, and those implications are enormous!

Whoo-hoo, now I can rim all the ass I want! (-1, Flamebait)

Anonymous Coward | more than 11 years ago | (#5762039)

Since I'm vaccinated against Hep A and B, I can now stick my tongue into other people's assholes to my heart's content. You wouldn't believe how many girls won't put out until they get a nice wet rimming.

Plus, now I can have Pamela Anderson!

Adaptation (3, Informative)

spotted_dolphin (595858) | more than 11 years ago | (#5762047)

We still have to remember that Hepatitis C is an RNA virus like HIV. RNA is inherently more unstable than DNA and thus undergo mutations at a much higher frequency. Just like the more effective treatments for HIV consist of cocktail mixtures (ie. AZT and ddI) the virus may still mutate into forms in which the inhibiting compounds no longer become effective. We certainly don't need these more resistant viruses being propogated!

Re:Adaptation (0)

Anonymous Coward | more than 11 years ago | (#5762205)

Yet we still want to try and keep people from dying. Just goes to show that the most effective treatment really is prevention. Of course, the golden chalice would be a drug that the hepatitis adapted to by becoming non-illness inducing . . .
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