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Geneticists Claim Aging Breakthrough

Zonk posted more than 8 years ago | from the lazarus-long-i-presume dept.

Sci-Fi 408

Quirk writes "The Science section of The Guardian is reporting on recent experiments by geneticists 'to unlock the secrets of the aging process has created organisms that live six times their usual lifespan, raising hopes that it might be possible to slow ageing in humans.' 'In the experiment, Dr Longo's team took yeast cells and knocked out two key genes, named Sir2 and SCH9. The latter governs the cells' ability to convert nutrients into energy. They found that instead of dying after a week, the cells lived for up to six weeks.''Research has now begun to test whether the effect works in mice.' So it looks like we might soon have near immortal, fearless mice."

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Hilander (4, Funny)

Morky (577776) | more than 8 years ago | (#14066733)

I am Mickey McMouse of the clan McMouse, and I am immortal.

Re:Hilander (1)

Luminary Crush (109477) | more than 8 years ago | (#14066815)

I for one welcome our new immortal headless-mice overlords!!

(come on, you know SOMEONE is going to post it, better to get it out of the way)

Re:Hilander (5, Funny)

hunterx11 (778171) | more than 8 years ago | (#14066882)

What's the sequence of the gene the prolongs life for you and me? CTGACTGCATC!

And soon our scientists will say... (5, Funny)

teko_teko (653164) | more than 8 years ago | (#14066918)

And soon our scientists will say stuffs like... Wernstrom: "Face it, Farnsworth, you're over the hill. It's time to leave science to the hundred-twenty-year-olds." Farnsworth: "You young turks think you know everything! I was inventing things when you were barely turning senile." Wernstrom: "Haha! Go home before you embarrass yourself, old man! Now if you'll excuse me, I'm going to take a nap before the ceremonies."

EXTRACT MY JUICES AND USE THEM ACCORDINGLY (-1, Offtopic)

(TK)Dessimat0r (668222) | more than 8 years ago | (#14066738)

LATVIAN HOUSE, QUIET AS SHIT, AREEMS WAS ASLEEP, STROKING HIS TIT, SUDDENLY WOKEN BY THE THOUGHTS OF FOOD, HE WANDERED DOWNSTAIRS TOTALLY NUDE, WITH A 1 INCH ERRECTION, HE OPENED THE FRIDGE, A MAN SAT BESIDE HIM, LADEN WITH GRIDS, THE MAN WAS A NIGGER, HE LOOKED LIKE A MESS, WHY WAS THIS MAN WEARING A DRESS? THIS MAN WAS A DARKIE FROM THE GNAA. UNKNOWN TO AREEMS, HE WAS TOTALLY GAY.

HIS 20 FOOT DONG STARTED TO RISE -- HE COULD SEE THE FEAR IN AREEMS' EYES. DON'T BE SHY, HE SAID, WITH A CAMP INFLECTION, ITS OKAY TO GET HIV FROM AN AIDS INFECTION. ANNOUNCING HIS PRESENCE, HE PLUNGED INTO AREEMS, HIS O-RING WAS TEARING AROUND THE SEAMS. AREEMS FELT HIS PRESENCE INSIDE HIS ASS, REMAINS OF DOUGHNUTS STILL YET TO BE PASSED.

THE BLACK MAN MOVED FURTHER INTO AREEMS, VISIONS OF CAKES STILL IN HIS DREAMS. THE NIGGER CAME AND THE BUG WAS PASSED, AREEMS GAVE A FUCK AS THE HOUSE WAS GASSED. THE SS WAS HERE, READY TO KILL, HITLER'S MEN GAVE OUT A SHRILL. "SCHNELL", THEY REPEATED, AS AREEMS WAS CAPTURED, PACKED INTO A TRAIN HEADED FOR RAPTURE.

WHEN HE ARRIVED, GREETED BY JEWS, THIS PLACE HAD FOOD -- HOW COULD HE LOSE? PACKED INTO A CELL AND GIVEN HIS FEAST, JEWISH CORPSES BLOATED WITH YEAST. A TASTE OF ZYKLON-B AS HE TUCKED IN, THIS PLACE WAS SOME SORT OF JEWISH BIN. COULD IT BE AUSCHWITZ? HE ASKED THE ASSCLOWN. HE LAUGHED AND SAID THAT THIS WAS IN FACT #BANTOWN.

AREEMS WAS CONFUSED -- WHY WAS HE HERE? FEASTING ON CORPSES FOR OVER A YEAR. YOUR POSTERIOR, HE SAID, IS USEFUL TO US. YOUR ANUS AFFORDS US A GREAT SOURCE OF PUS. THE FATTER YOU GET, THE MORE YOU PRODUCE, WE WANT YOUR ASS TO BE TOTALLY LOOSE. OUR MEMBERS ARE KILLED AND THEN FED TO YOU, WE EXTRACT YOUR PUS TO USE IN OUR COUP.

AREEMS COULDN'T CARE LESS, AS LONG HE FED, IT SADDENED HIM TO HEAR THAT HIS FRIENDS WERE DEAD. AREEMS GREW TO HIS CAGE AND THEN READIED HIS REAR, THE LOOK ON HIS FACE WAS ONE OF FEAR. THE DEVICE WAS TURNED ON, AND A WHIRRING BEGAN. THE PUS WAS EXTRACTED INTO A PAN. THIS WAS THEN EMPTIED INTO A BOTNET DEVICE -- A LINUX SERVER THAT ALREADY CRASHED TWICE.

THE MACHINE CAME ONLINE, AND ENTERED #GNAA, CAUSING A SMALL AMOUNT OF DISMAY. THE OPS SET A PASSWORD, AND THE CHANNEL WAS STILL. IT SEEMS THEIR DEVICE DID NOTHING TO KILL. FAILURE OCCURED, AND BANTOWN WAS SHIT, THEY WROTE ON THEIR BLOGS THAT THEIR WRISTS HAD BEEN SLIT. WHAT A PATHETIC EXISTENCE, AREEMS SAID AS HE CRIED, HE WAS TRAPPED IN HIS CAGE UNTIL HE DIED.

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OUTGOING (-1)

Anonymous Coward | more than 8 years ago | (#14066742)

HELLO WORLD
73764 73764
HELLO WORLD
18145 18145 93749 93749 66605 66605 89313 89313 81084 81084
61329 61329 63889 63889 64063 64063 46581 46581 50407 50407
79597 79597 55359 55359 29620 29620 82344 82344 80348 80348
38122 38122 31953 31953 27193 27193 94773 94773 42829 42829
21653 21653 96243 96243 37880 37880 17856 17856 15566 15566
91364 91364 96358 96358 92495 92495 25471 25471 93445 93445
34014 34014 36596 36596 76276 76276 20441 20441 57696 57696
75924 75924 10067 10067 25262 25262 20149 20149 82648 82648
52341 52341 96071 96071 35782 35782 28127 28127 47168 47168
74938 74938 85531 85531 39748 39748 27445 27445 47792 47792
69203 69203 52811 52811 04154 04154 94076 94076 84688 84688
36568 36568 59305 59305 43995 43995 32260 32260 23148 23148
48578 48578 52209 52209 16300 16300 02930 02930 90586 90586
32263 32263 35455 35455 60162 60162 82518 82518 03657 03657
95015 95015 56121 56121 05594 05594 22483 22483 44522 44522
77163 77163 51545 51545 76103 76103 84601 84601 66931 66931
96992 96992 93925 93925 48537 48537 89117 89117 46894 46894
09491 09491 23162 23162 50568 50568 37801 37801 87094 87094
85333 85333 93375 93375 57471 57471 47222 47222 02011 02011
00807 00807 42022 42022 38112 38112 89532 89532 52169 52169
89758 89758 95948 95948 09992 09992 86935 86935 52378 52378
62779 62779 71299 71299 41818 41818 89081 89081 74059 74059
65508 65508 39975 39975 44211 44211 20918 20918 67913 67913
55540 55540 91232 91232 84946 84946 15372 15372 58415 58415
98994 98994 79642 79642 54516 54516 69112 69112 71919 71919
35906 35906 25025 25025 37243 37243 42053 42053 76182 76182
19033 19033 11522 11522 18782 18782 71293 71293 28021 28021
53651 53651 84649 84649 65325 65325 94223 94223 32475 32475
33803 33803 99533 99533 23530 23530 00408 00408 32716 32716
11989 11989 06571 06571 78222 78222 52817 52817 55062 55062
32556 32556 14433 14433 25308 25308 89446 89446 32985 32985
39570 39570 93574 93574 69573 69573 21113 21113 46247 46247
07743 07743 25423 25423 58270 58270 53680 53680
K-BYE

Worms (1)

ZeroExistenZ (721849) | more than 8 years ago | (#14066747)

didn't they find the secret of aging in worms some while ago?

Apologies in advance, but... (-1)

Anonymous Coward | more than 8 years ago | (#14066748)

I, for one, welcome our new immortal, fearless rodent overlords.

Re:Apologies in advance, but... (2, Interesting)

joey_knisch (804995) | more than 8 years ago | (#14066892)

The fear gene makes sure they stay alive.
The aging gene makes sure they die eventually.

If you turn both off you just get a dumb mouse that dies to stupidity instead of old age.

We have that already (5, Informative)

Chowser (888973) | more than 8 years ago | (#14066751)

We have cells already that are not governed by the normal life/death cell cycle. It's called CANCER. Cancer cells have autononmous growth and multiply indefinitely.

you and I just cured cancer (0)

Anonymous Coward | more than 8 years ago | (#14066783)

So... we just need to knock those Sir2 and SCH9 genes INTO the cancer cells and cancer will die off!

PATENT PENDING.

Re:We have that already (1)

sgeye (757198) | more than 8 years ago | (#14066807)

Yes, but cancer cells don't stay in interphase long enough to do their normal functions. They go through the cell cycle faster than normal, splitting more often than normal cells, which is why they end up causing tumors.

Re:We have that already (4, Informative)

iamplupp (728943) | more than 8 years ago | (#14066960)

You are over simplifying. For a normal cell to become a tumor cell all of the following mutations are required:

* telomerase activity
* insensitivity to apoptosis by either disrupting the proapoptotic signal pathway (Bax, P53, effector-caspase etc) increase the expression of antiapoptotic signals such as Bcl-2
* growth factor independence (ie constitutively active Ras)
* insentivitity to growth inhibitors
* proangiogenetic mutations

Re:We have that already (1)

mattsucks (541950) | more than 8 years ago | (#14066989)

I thought cancer cells die just like regular cells; however their vastly increased reproduction rates, over time, cause the "cancer" effect and runaway growth?

i know when we will see these benefits (5, Funny)

circletimessquare (444983) | more than 8 years ago | (#14066752)

i know exactly when these amazing age-related breakthroughs will come to fruition for humanity

exactly at the age at which i am too old to partake of any of it

Re:i know when we will see these benefits (1)

PatrickThomson (712694) | more than 8 years ago | (#14066825)

Perfect, I'm a year younger than you!

Re:i know when we will see these benefits (1)

timster (32400) | more than 8 years ago | (#14066866)

Yeah, so the big question for the rest of us is: how old are you two?

Re:i know when we will see these benefits (1)

Cunk (643486) | more than 8 years ago | (#14067033)

Do you really need to know both their ages?

It's gonna get.. (3, Interesting)

earthloop (449575) | more than 8 years ago | (#14066753)

..real crowded in the world if we're all immortal.

Re:It's gonna get.. (4, Funny)

wiggles (30088) | more than 8 years ago | (#14066823)

No problem. Just make sterilization a prerequisite for immortality.

We need vampires and werewolves . . . (1)

StefanJ (88986) | more than 8 years ago | (#14066939)

. . . to cull the herd. This will encourage people to stay fit and get home at a decent hour.

Or maybe getting anti-aging drugs will require a survey of your friends and neighbors.

If you flunk, or no one returns the survey, you don't get boosterspice, because who needs a bunch of old, unpopular jerks hanging around?

Re:It's gonna get.. (0)

Anonymous Coward | more than 8 years ago | (#14066950)

I for one welcome our fearless geriatric rodentine overlords

Re:It's gonna get.. (4, Funny)

19thNervousBreakdown (768619) | more than 8 years ago | (#14066958)

Not if I have anything to say about it.

There can be only one.

Re:It's gonna get.. (1)

Wes Janson (606363) | more than 8 years ago | (#14067015)

That's what Soylent Green is for.


Remember what Stalin said: no man, no problem.

Fearless cancels out Immortal (2, Insightful)

intmainvoid (109559) | more than 8 years ago | (#14066754)

Unfortunately being fearless is going to cancel out immortality pretty quickly, when the mouse isn't scared of humans, or their traps...

Re:Fearless cancels out Immortal (2, Funny)

Donut2099 (153459) | more than 8 years ago | (#14066816)

Don't forget that they can regenerate body parts, so the only way to kill them is to cut their head off. There can be only one...

Re:Fearless cancels out Immortal (4, Funny)

dmuth (14143) | more than 8 years ago | (#14066830)

At the rate of mice-related stories we've been getting on Slashdot lately, I'm getting worried that the next one is going to be how scientists found a way to make mice smarter.

"What are we going to do tonight, Brain?"
"Same thing we do every night, Pinky: try to take over the world!"

Re:Fearless cancels out Immortal (2, Funny)

intmainvoid (109559) | more than 8 years ago | (#14066897)

Perhaps it's been done and a new breed of super inteligent mice have taken over slashdot?

Oh, great more old people (5, Funny)

BobCat7 (851805) | more than 8 years ago | (#14066755)

At this rate I'm never gonna get to sit at the big table on Thanksgiving

Yawn (5, Funny)

ENOENT (25325) | more than 8 years ago | (#14066756)

Where we can get fearless, immortal, FLYING mice, then I'll be excited.

Especially if they can also sing "Here I come to save the day."

Re:Yawn (1)

kabocox (199019) | more than 8 years ago | (#14066981)

Where we can get fearless, immortal, FLYING mice, then I'll be excited.

Especially if they can also sing "Here I come to save the day."


Hey, we just need to splice in some bat DNA and we can have vampire, flying fearless, immortal mice.

Oh come on... (0)

Anonymous Coward | more than 8 years ago | (#14066761)

Who wants to live forever?

Re:Oh come on... (1)

gnuLNX (410742) | more than 8 years ago | (#14066803)

Yep..that would be me. I would like to live forever.

fantastic (2, Funny)

Tumbleweed (3706) | more than 8 years ago | (#14066763)

This will give Brain time to take over the world!

Re:fantastic (1)

drinkypoo (153816) | more than 8 years ago | (#14066931)

Only if Pinky doesn't receive the same treatment.

I don't see the point of extending life. (3, Insightful)

Spazntwich (208070) | more than 8 years ago | (#14066764)

Unless breakthroughs like this can improve the quality of life, it's a neat but ultimately worthless advance. Humans already life way longer than the length of time they're useful to society, and if we suddenly have people living 6 times as long but still degrading by 70-90, we're just going to sink even more quickly.

Now, humans living a few hundred years and staying able-bodied for most of it would be an incredible advance and would probably serve to benefit society, but... otherwise... I fear and do NOT welcome our new 400-year-old jello eating overlords.

Re:I don't see the point of extending life. (3, Funny)

RootsLINUX (854452) | more than 8 years ago | (#14066787)

So in other words, I should invest my money in retirement homes?

Re:I don't see the point of extending life. (1)

Spazntwich (208070) | more than 8 years ago | (#14066919)

I'd invest in advanced crap filtering on /.

Can you imagine the number of unholy lemonparty ripoffs that will be springing up once our troll population hits a mean age of 200?

Re:I don't see the point of extending life. (1)

Philip K Dickhead (906971) | more than 8 years ago | (#14066949)

Think of the unemployment figures!

What? (-1, Troll)

Anonymous Coward | more than 8 years ago | (#14066773)

What is 'ageing'? Submitters now switch between American and British spellings now?

BILL CURTIS (-1, Troll)

Rodney.Quills.Dinkin (932254) | more than 8 years ago | (#14066775)

Does this mean Bill Curtis will live FOREVER?

I, for one.... (-1, Redundant)

Anonymous Coward | more than 8 years ago | (#14066777)

welcome our new fearless, near immortal mouse overlords!

just immortal and fearless? (1)

Red Flayer (890720) | more than 8 years ago | (#14066780)

"So it looks like we might soon have near immortal, fearless mice."

I think you meant immortal, fearless, singing, regenerating, plague-infected mice.

Can't be bothered pasting all the links, here's the link to the /. old stories results page for mice: http://slashdot.org/search.pl?tid=&query=mice&auth or=&sort=1&op=stories [slashdot.org]

Sorry, couldnt resist (0)

Anonymous Coward | more than 8 years ago | (#14066782)

Mighty Mouse will save the day!!!

I Know It's Overdone, But... (2, Funny)

JohnPerkins (243021) | more than 8 years ago | (#14066792)

I for one welcome our fearless, near-immortal, rodent overlords.

(that wouldn't be Frankie and Benjie mouse, by an chance, would it?)

Obligatory (0)

Anonymous Coward | more than 8 years ago | (#14066793)

In Korea, only old people .. Ehm ...

Hitch Hiker's Guide was right!?!?!? (3, Funny)

RingDev (879105) | more than 8 years ago | (#14066796)

Fearless imortal mice?!? Maybe my "wanna see my spaceship" pick up line will start working again!

-Rick

And... (0)

Anonymous Coward | more than 8 years ago | (#14066801)

this is a good idea why, now?

Moral Questions: (2, Interesting)

under_score (65824) | more than 8 years ago | (#14066806)

If this works (eventually) with humans, who will get access to it? How will we justify the use of this when so many people die very young from preventable causes that are beyond their control (as opposed to simply not taking care of oneself)? How will we prevent the extreme accumulation of wealth that this would allow if it is not equally accessible to everyone?

Re:Moral Questions: (1)

wuie (884711) | more than 8 years ago | (#14066888)

Hell, how can we justify this when we're still not able to feed every mouth in the world as it is, or have enough jobs for every set of hands? The last thing our planet needs right now is an ever-producing, never-dying species.

Re:Moral Questions: (1)

gnuLNX (410742) | more than 8 years ago | (#14066945)

good question...just give me the forever pill and I sir wil provide you with the answer to you question.

Seriously

"How will we prevent the extreme accumulation of wealth that this would allow if it is not equally accessible to everyone?"

And how is it going to be any different. We already have several people with over a billion dollars in net woth. I have a hard time wrapping my mind around how much a billion is. I would say that at some point (perhaps a billion) more doesn't provide you with anything so why keep trying?

Re:Moral Questions: (1)

rask22 (144831) | more than 8 years ago | (#14066969)

The amount of funding spent on anti-aging research is TINY compared the total US research budget.

"How will we justify the use of this when so many people die very young from preventable causes"

Um, because allowing normal people to die while there is a cure for their aging would be akin to murder?

I for one (0, Redundant)

604badder (817383) | more than 8 years ago | (#14066810)

I for one, welcome our fearless immortal rodent overlords.

There are old mice... (1)

ibn_khaldun (814417) | more than 8 years ago | (#14066812)

There are old mice, and there are bold mice, but there are no old, bold mice

Adams had it right... (0)

Anonymous Coward | more than 8 years ago | (#14066821)

These latest annoucements of genetically engineered super-mice have me wodering if Douglas Adams had it right and we are all pawns to the super-intelligent mice that rule the earth. =D

Wow.... (1)

wpiman (739077) | more than 8 years ago | (#14066828)

Hey- check out the legs on that 90 year old over there. She is one smoking granny.

So ninety would be like the new 20s?

The sad thing is- they wouldn't change the retirement age- and people would collect SS for 5/6th of their lifespan. The polticians wouldn't touch that hot potato. Our tax rates will be 80% of our income.

Re:Wow.... (3, Funny)

mcfuddlerucker (883634) | more than 8 years ago | (#14066885)

>> Our tax rates will be 80% of our income.

So... stopping this aging gene also turns us into Swedes?

Good and bad news (1)

nizo (81281) | more than 8 years ago | (#14066829)

Good news: you get to live to be 570 years old
Bad news: for 500 of those years you have to wear diapers and are senile

Gee it sounds like a dream come true.

Mammals aren't exactly fungi (2, Informative)

n0dalus (807994) | more than 8 years ago | (#14066834)

It's a huge jump to say that a single-celled fungi's life can be improved to saying it can also be done for a mammal with thousands of different kinds of cells and billions of cells in total. A lot of our physiology actually relies on cells having a short lifetime. I doubt those mice will even live one day.

Narf! (1, Funny)

Chuckstar (799005) | more than 8 years ago | (#14066847)

"Pinky, are you thinking what I'm thinking?"

"I think I am, Brain, but wherever are we going to find cool whip and rubber shorts at this hour?"

Re:Narf! (0)

drinkypoo (153816) | more than 8 years ago | (#14066972)

"I think so brain, but where are we going to find rubber pants our size?"

Yeast not mice. (1)

rask22 (144831) | more than 8 years ago | (#14066862)

Like the subject title says, this study was done on yeast, not mice. And while it's a cool study and there are homologs between yeast and humans, don't expect 6 fold life span improvements in humans anytime soon.

Re:Yeast not mice. (1)

HolyCrapSCOsux (700114) | more than 8 years ago | (#14067023)

So we can brew 6X stronger beer, 6X fluffier bread.
And for today's sick joke.....
Gynecologists can be EVEN RICHER!!!!.

Yeah, I'll go to h-e-double-hockeysticks for that one.

Just what the earth needs (1)

Barkley44 (919010) | more than 8 years ago | (#14066865)

So if we can extend the average lifespan 6X, given that it currently sites close to 75 years old, in 450 years, the world population, if it doesn't keep growing (which it is) will be 36 billion? Just what we need in 450 years, 6 billion 300 year olds. And you think some elderly slow up the line now ;)

Re:Just what the earth needs (1)

wpiman (739077) | more than 8 years ago | (#14066953)

I would assume that this therapy would only go to people in the wealthier countries. If you are licking water out of a puddle- do you really want to live for 450 years?

Also- if the average age is 75- what percentage of people are killed by non-old age/disease things during their lifetime? (Hurricanes, terrorism, car crashes, etc) If you lived to 450- you'd be probably 6 times more likely to be killed by other factors. So the number would probably be less.

transhumanists miss the point (2, Interesting)

jimjamjoh (207342) | more than 8 years ago | (#14066870)

without waxing too poetic, life isn't about accumulating more moments, it's about investing the ones we have with as much quality as possible. life is short, but beautiful on account...if we had lifespans that measured on the geologic scale (or any scale much beyond the one we have present), the individual choices we make become less and less meaningful. quality over quantity, as always...

Re:transhumanists miss the point (2, Insightful)

truckaxle (883149) | more than 8 years ago | (#14066954)

err can you define "quality". When you say "life is short, but beautiful on account" on whose or what account. To take your conclusion to the extreme the most beautiful and quality filled life would be those that a week live.

Concern? (1)

letdinosaursdie (809029) | more than 8 years ago | (#14066875)

I hope they don't escape.

IMAGINE ALL THE PEOPLE (0)

Anonymous Coward | more than 8 years ago | (#14066876)

John Lennon could still be alive today if he was a mouse.

Big deal (1)

Frangible (881728) | more than 8 years ago | (#14066877)

This isn't even an animal study, this is a purely in vitro model which means it may or may not translate to anything beyond that. All of the other "anti-aging breakthroughs" in animal models failed to produce the same results in humans. Cell lifespan alone isn't the reason humans die of old age, as the telomerase research showed.

Great news if you're a yeast cell and like having a sluggish metabolism, though!

great... (1)

ltwally (313043) | more than 8 years ago | (#14066878)

"...has created organisms that live six times their usual lifespan, raising hopes that it might be possible to slow ageing in humans."
Great... this is just what our world needs. Half of Africa is malnourished and in China a woman is only allowed 1 child in her lifetime... and we're considering increasing our lifespans to 6x.

Science is really neat, and all that... but sometimes, I swear, scientists don't think of the repurcussions of their actions. Do they take into consideration food consumption? Living space? Energy requirements? Don't get me wrong, I'm no hippy... but I can see some serious harm coming from this.

If this were some drug that were only given out to our brightest minds, I'd be all for it. But if something like this is actually applied to the population, en-mass, the end result will be catastrophic.

Just my $0.02... maybe the rest of you aren't so cynical.

Re:great... (1)

rask22 (144831) | more than 8 years ago | (#14066926)

Considering that the richest countries in the world, the ones that will be getting life extension tech first, mostly have shrinking populations... I don't think it would be a bad thing.

Re:great... (0)

Anonymous Coward | more than 8 years ago | (#14066929)

That is what nukes are for. Read 1984.

Oh, and yes, we are as cynical.

Re:great... (1)

Quaoar (614366) | more than 8 years ago | (#14066941)

Society will adapt to the increase in life-span, just as it has adapted to the increase in life-span we've already seen. And, if the treatment allows newborns to live 6 times as long, and age much slower, think of how smart we'd become. If the brain doesn't degrade over the course of 300 years, you could have all sorts of intellectual insight that is currently stifled by old age. Imagine if Einstein were still alive today, bright as ever!

Re:great... (1)

Frangible (881728) | more than 8 years ago | (#14066966)

As a whole, the population in first world countries is on a decline other than immigration. Not to mention this study has about zero relevance for humans. Now get a haircut, stop smoking pot, and uncurl your arms from around that tree.

Re:great... (1)

grasshoppa (657393) | more than 8 years ago | (#14066979)


Just my $0.02... maybe the rest of you aren't so cynical.


Cynical is a healthy state of being in this world. You, however, are not cynical. You could almost be called a hypocondriac ( spelling ).

This works in fungus. Mammals are a whole different ball game. Further, if science were to slow down and consider the implications of all their work, we'd never have gotten fire.

It's not up to them to consider the implications of their work. It's up to our leaders, at least that's how it's setup. No, I don't much like that either, but there you go.

Re:great... (2, Funny)

RevMike (632002) | more than 8 years ago | (#14067019)

Don't worry. Scientists are also developing this new substance called soylent green which will help feed all these people.

Red Mars trilogy - prophetic (1)

Luminary Crush (109477) | more than 8 years ago | (#14066879)

There are ALOT of social problems which will come out of extreme human longevity. It seems to me that a good read of Kim Stanely Robinson http://www.kimstanleyrobinson.net/ [kimstanleyrobinson.net] would be in order long before something like this has human applications.

in the 487th year of his mightiness... (1)

St0rmwarden (759530) | more than 8 years ago | (#14066883)

One of the things you can count on in life is that [insert greedy, cruel tyrant/dictator's name here] will die eventually, just like the rest of us.

So what happens when they can use their money to hang around for another 500 years?

How would your typical impovershed (sp?) 3rd world country deal with a 500 year reign of terror?

Clone troopers (0)

Anonymous Coward | more than 8 years ago | (#14066887)

Hmmm all we need to is to get be able to clone humans in a reduced period of time and train them constantly in war tatics and we can have our very own imperial troopers.

Do not go gently into that goodnight.... (4, Interesting)

truckaxle (883149) | more than 8 years ago | (#14066898)

Longevity will provide the next inflection point of human capacity and progress. Imagine if the great people of science could continue to contribute and innovate for the equivalent of several lifetimes. Gauss was the last mathematician who was said to be able to be conversant with the entire spectrum of mathematics. Currently it takes a human a decade to two just to be abreast of a specific field of science to be able to make any significant contributions. The period of time available to advance our understanding is getting shorter and shorter due to increase in the body of knowledge and our limited life times.

I know there will be the crowd that says - but we were designed to die. That is bunk! Self aware intelligence is bound and destined to perpetuated and proliferate.

This sounds like SENS (1)

Sam Haine '95 (918696) | more than 8 years ago | (#14066923)

Strategies for Engineered Negligible Senescence [cam.ac.uk] at my university have been going on about stuff like this for a while. Personally I think it's all science fiction but hey...

This is not something that was previously unknown. (4, Interesting)

Biotech9 (704202) | more than 8 years ago | (#14066930)

Here's a simple way to increase your lifespan. Eat less. In fact, halve the amount of food you eat.

There are papers that you can search for with sciencedirect.com or scholar.google.com that show rats that are given half the calories of the control group living almost 50% longer. It's just not exactly something that you can sell to people. You can live longer, if you live LESS. There's a reason animals that live very long lives have very slow metabolisms (such as Turtles) and animals that have very high metabolisms live less (such as humming birds and mice). To put it simply, you can 'burn the midnight oil' and live a short life, or eat less and do less and live longer.

Putting it more complicatedly, the reason you age is generally regarded to be because of damage your body and cells accumulate over a lifetime of living. The damage often comes from 'Oxidative stress'. This is just a very broad umbrella term for anything that causes the generation of 'Reactive oxygen species' that are highly reactive molecules that zip about your cell damaging proteins and DNA. ROS are made by things such as too much Vitamin K, smoking, UV light or certain other radiation bands, too much iron in the diet, and so on.

And the biggest contributor to ROS in your body over it's life? The Mitochondria. The 'power plant' of each cell. It makes ROS as a part of the process used to make ATP (the 'batteries' of your cells) and inevitably some escapes and causes damage. Over a life-time the damage builds up.

The biggest contributor to ageing is just plain old living (kind of obvious really), and the best way to therefore cut down on that damage is to eat less, slowing down the metabolism and decreasing the amount of ROS the mitochondria produces.

IMHO, not really worth it! you could get hit by a bus tomorrow! Dig into your fresh Chiabatta and Fetta cheese!

Re:This is not something that was previously unkno (1)

vinnythenose (214595) | more than 8 years ago | (#14066983)

crap. So because of my high metabolism, I may not be able to put on weight, but I'm going to die by 40.
You just can't win!

Re:This is not something that was previously unkno (3, Funny)

badfish99 (826052) | more than 8 years ago | (#14066994)

Is that why all those starving people in Africa all live to be 180 years old?

Re:This is not something that was previously unkno (1)

Frangible (881728) | more than 8 years ago | (#14066998)

No, this won't increase lifespan in a human. Yet another rat study that failed to translate into human data. Oxidative stress is one factor amongst many. To say aging is complex is an understatement.

Re:This is not something that was previously unkno (1)

iamplupp (728943) | more than 8 years ago | (#14067026)

Shouldnt that also mean that lots of vitamin C, vitamin E and catalase in the diet would increase your lifespan? If I recall correctly these are the major substances involved in neutralizing ROS.

This is likely a "duh" sort of thing (1)

PIPBoy3000 (619296) | more than 8 years ago | (#14066935)

People have known for a long time that starving organisms and individual cells promotes long life. Likely there's a bunch of things going on, from reduction in oxidation damage of the cell to the cell expressing genes to cope with the minimal amount of nutrients it's able to process.

A good analogy is that the cells go into a "hibernation" of sorts, not doing much, but not dying either. I suspect that some sort of drug may come out of this, but it'll likely have the side effect of people wanting to sit around and not do much as their cells are starved of energy. Not a big change for some of you, I realize, but there's always a price to be paid for these sorts of things.

Duke Nukem.. (1)

slashmojo (818930) | more than 8 years ago | (#14066937)

Mice around the world cheer on hearing they will live to see duke nukem forever released.. or not.

Same mice talk smack about busting a cap in duke nukems ass.

Scary (1)

drxenos (573895) | more than 8 years ago | (#14066947)

I have two problems with this:
1) I'd be worried what those genes did that they knocked out. I mean, I don't want to live six times longer and be impotent the whole time.
2) There are a lot of asshats I don't want to live six times longer. The really scary thing is I'm related to some of them.

In Solvat Russia... (0)

Anonymous Coward | more than 8 years ago | (#14066964)

Fearless, immortal mice break you!

STOP (1)

doyoulikegoatseeee (930088) | more than 8 years ago | (#14066965)

stop exploiting mice for your crackpot bullshit. this is stupid and needs to end.

I for one welcome our new Disney overlords! (3, Funny)

ave19 (149657) | more than 8 years ago | (#14066976)

This is all a ploy by Disney to justify keeping Micky under copy-wraps for 600 years.

Why? (0)

Anonymous Coward | more than 8 years ago | (#14066985)

At the current population's growth rate, we're already filling the planet with 83.3 million more people every year. That's almost 3 people every second. Think about that.

Now, think about the kinds of overcrowding that places like India and China enjoy.

Do you *really* want people to live longer?

In the time it took me to write this, another 200 people just started breathing your air and eating your food. By the time this thread works down off the front page, about 40,000 people will have appeared to take your jobs.

I'm thinking that living longer is NOT a good thing unless it also comes with an anti-fertility side-effect.

Live 6 time longer .... slowly (1)

wom (240411) | more than 8 years ago | (#14066987)

So they make mice not able to metabolize food (ie. starve) and make thier cells too stupid to die on cue (ie cancer) and this is a good thing? We know that starving people live a long time (see URL:http://www.webmd.com/content/article/110/10981 8.htm ) but are they LIVING? or existing? I'll take living any day.

I don't think those mice would be that immortal (1)

kabocox (199019) | more than 8 years ago | (#14067008)

I think the mice that had some fear would be more immortal than the mice that were fearless. Now, the fearless solider mice are the ones that you'd want to send biting lions and tigers to death while most of your immortal peasant mice run way because they are scared.

Aging and birth (1)

subl33t (739983) | more than 8 years ago | (#14067010)

Unless these scientists find a way to make humans less fertile, planet earth is gonna get ugly crowded.

In Korea... (1)

TheSpoom (715771) | more than 8 years ago | (#14067029)

Only old mice are fearless.
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