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New drugs trail many old ones in effectiveness against disease

Lasrick (2629253) writes | about a year ago

2

Lasrick (2629253) writes "Interesting. From the article: "While experts agree that tougher trials and similar factors explain some of the decline in drugs' reported effectiveness, "something real is going on here," said Olfson. "Physicians keep saying that many of the new things just aren't working as well," and therefore prescribe antidepressant drugs called tricyclics (developed in the 1950s) instead of SSRIs (from the 1980s), or diuretics (invented in the 1920s) for high blood pressure instead of newer anti-hypertensives.""
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No evidence, but... (1)

Telecommando (513768) | about a year ago | (#43910419)

Perhaps the older drugs were manufactured for maximum effectiveness and the newer ones for maximum profit.

Alternatively (1)

Okian Warrior (537106) | about a year ago | (#43910573)

I think your explanation is likely, and here's another possibility.

Drugs with good efficacy are rare - the typical case is moderate to low effectiveness.

Since developing a drug is now so hard/expensive/time consuming, only one or two are developed and released per year. Statistically, these are more likely to have low or moderate effect.

If there were some way to speed up the drug trial process so that more drugs are tried in a year, we would be more likely to find the effective ones.

(Perhaps allowing informed patients to set a different level of acceptable risk in cases of severe illness.)

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