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Depletion of 'traitor' immune cells slows cancer growth in mice

vinces99 (2792707) writes | about 7 months ago

0

vinces99 (2792707) writes "When someone has cancer, some of the body's cells have changed and are growing uncontrollably. Most cancer drugs try to treat the disease by killing those fast-growing cells, but another approach called immunotherapy tries to stimulate a person’s immune system to attack the cancer itself. Now, scientists at the University of Washington have developed a strategy to slow tumor growth and prolong survival in mice with cancer by targeting and destroying a type of cell that dampens the body’s immune response to cancer. The researchers published their findings this week (Sept. 16) in the Proceedings of the National Academy of Sciences. Our immune system normally patrols for and eliminates abnormal cells. Macrophages are a type of helpful immune cell that can be converted to the “dark side” by signals they receive from a tumor. When inside a tumor, macrophages can switch from helping the immune system to suppressing the body’s immune response to cancer. Several studies show a correlation between the number of macrophages in tumor biopsies and poor prognosis for patients, the researchers say. The UW team developed a method to target and eliminate the cancer-supporting macrophages in mouse tumors. This strategy, the researchers predict, could be used along with current treatments such as chemotherapy for cancer patients."
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