Beta
×

Welcome to the Slashdot Beta site -- learn more here. Use the link in the footer or click here to return to the Classic version of Slashdot.

Thank you!

Before you choose to head back to the Classic look of the site, we'd appreciate it if you share your thoughts on the Beta; your feedback is what drives our ongoing development.

Beta is different and we value you taking the time to try it out. Please take a look at the changes we've made in Beta and  learn more about it. Thanks for reading, and for making the site better!

Organ regenerated inside a living animal for the first time

ananyo (2519492) writes | about 5 months ago

0

ananyo (2519492) writes "Scientists at Edinburgh University have successfully persuaded an organ to regenerate inside an animal. As they report in the journal Development, they have treated, in mice, an organ called the thymus, which is a part of the immune system that runs down in old age. Instead of adding stem cells they have stimulated their animals’ thymuses to make more of a protein called FOXN1. This is a transcription factor (a molecular switch that activates genes).
The scientists knew from earlier experiments that FOXN1 is important for the embryonic development of the thymus, and speculated that it might also rejuvenate the organ in older animals. They bred a special strain of mice whose FOXN1 production could be stimulated specifically in the thymus by tamoxifen, a drug more familiar as a treatment for breast cancer.
In one-year-olds, stimulating FOXN1 production in the thymus caused it to become 2.7 times bigger within a month. In two-year-olds the increase was 2.6 times. Moreover, when the researchers studied the enlarged thymuses microscopically, and compared them with those from untreated control animals of the same ages, they found that the organs’ internal structures had reverted to their youthful nature."

Link to Original Source

cancel ×

0 comments

Sorry! There are no comments related to the filter you selected.

Check for New Comments
Slashdot Login

Need an Account?

Forgot your password?

Submission Text Formatting Tips

We support a small subset of HTML, namely these tags:

  • b
  • i
  • p
  • br
  • a
  • ol
  • ul
  • li
  • dl
  • dt
  • dd
  • em
  • strong
  • tt
  • blockquote
  • div
  • quote
  • ecode

"ecode" can be used for code snippets, for example:

<ecode>    while(1) { do_something(); } </ecode>