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Protien in HIV functions as resistor

TwilightXaos (860408) writes | more than 7 years ago

Biotech

TwilightXaos writes "Leor Weinberger and Thomas Shenk, two researchers at Princeton, have discovered a new model for how the HIV (Human Immunodeficiency Virus) enters and exits dormancy. They claim it functions as a resistor, this is in contrast to other types of regulation models found in other viruses and animals. From the abstract:

Here we show that a dissipative feedback resistor, composed of enzymatic interconversion of the transactivator, converts transactivation circuits into excitable systems that generate transient pulses of expression, which decay to zero. We use HIV-1 as a model system and analyze single-cell expression kinetics to explore whether the HIV-1 transactivator of transcription (Tat) uses a resistor to shut off transactivation. The Tat feedback circuit was found to lack bi-stability and Tat self-cooperativity but exhibited a pulse of activity upon transactivation, all in agreement with the feedback resistor model.

The research could lead to an effective treatment of the HIV virus, and has the possibility of increasing understanding of other viruses like herpes.
Additionally hindu.com has a article on the findings."

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