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DNA Project 'to Make UK World Genetic Research Leader'

K10W Re:First steps (65 comments)

There's a big difference between mapping the genomes of cancer patients and developing individualized treatments, akin to the difference between being able to read a novel and being the editor. As it is, we can't even understand most of the human genome, but I suppose this is a step in the right direction.

Bearing in mind Cameron is an oaf I wouldn't be surprised if it was being rolled out for either similar behind the scenes purpose not too far off what you state, or another tory get rich[er] quick scheme. After all a lot of the gov investment and involvement in fair bit of projects has been a shill reasons with high vested interest, shares and so on in such things being the driving force and even willingness to damage the stated aim if it means more money.

about three weeks ago
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Dealing With 'Advertising Pollution'

K10W Re:Good point (418 comments)

I have adblock.

Have you tried to use Youtube without adblock? It's broken - the page looks like garbage, and the video is about the size of a postage stamp.

I really don't know what else I am supposed to do other than completely avoid youtube, which is really hard to do :(

I'd go try that out a gain and experiment what is messing your settings up since I didn't realise youtube had ads until this story. I use adblock plus and it works but make sure you have disable unintrusive ads. Fwiw I use some other things which could affect it like noscript and ghostery. Yeah the latter two are very similar but I use in particular way, such as slashdot is whitelisted in noscript but the trackers are blocked by ghostery.

By whitelisting in either ghostery or noscript and setting selective permissions in the other I effectively have simple way of managing different permissions for same tracker/script etc for different sites for instance blocking Google analytics on most sites but enabling where it is favourable on a select few sites. It also means even whitelisted domains have filtering of some things still.

about a month ago
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Ode To Sound Blaster: Are Discrete Audio Cards Still Worth the Investment?

K10W Re:No. (502 comments)

No doubt that gold plated connectors don't oxidize, but does the oxidation cause real issues with sound quality, in any meaningful measurement? How much oxidation would be required before a noticable degradation in signal would occur?

I really don't know at what point it'd be an issue and personally couldn't even guess. Worst I've seen oxide buildup was NiMH powered old portable units for small setups or backups; line in recorders and portable phantom power supplies for mics. That was just the battery contacts on them not the xlr's sockets, I'd guess because batteries had been used under 20min fresh off the charger so still degassing which speeds up the buildup and done over long time on regular basis. They worked but getting rid of weak points is just good practice I guess and when people depending on the result best not taking chances and it is one less thing to worry about when you need to troubleshoot problems.

Metal migration seems more of the issue though as I'd been warned about that in some stuff but never seen it myself. All the 1/4" jacks and xlr's I've seen have been none GP types so the oxides can't be significant problem in average situations or it'd be more common seeing the GP stuff. Most the places it is used will be for marketing reasons like with silver cable with the skin effect myths. Of course there is some truth to it but it doesn't really affect audio and marketing kind of draws wrong conclusions to sell snakeoil essentially.

about a month and a half ago
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Ode To Sound Blaster: Are Discrete Audio Cards Still Worth the Investment?

K10W Re:No. (502 comments)

Why do you lump Klipsch in with Monster Cables? The founder of Klipsch is renown for debunking many crap claims made by many speaker makers similar to the nonsense claims that Monster makes. Perhaps you mean "No highs. No lows. It's Bose"? K-horns, for example, have always been solid speakers.

exactly what I thought. Don't get me started on bose but klipsch have done a lot of good and fair amount of their good stuff is cheap too.

about a month and a half ago
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Ode To Sound Blaster: Are Discrete Audio Cards Still Worth the Investment?

K10W Re:No. (502 comments)

Only if you use the gold plated cables.

actually they can have their place in studios although I have rarely seen it. Gp terminations makes no difference to signal of course and thickness of some is crap so it wears fast when plugging/unplugging on regular basis. However on the stuff that stays hooked up for long periods it has 2 purposes,first the GP doesn't matter BUT mixing GP and none plated does since mix metals leads to various issues so if the breakout boxes or whatever are GP then so are the terminations. Most studio gear I see doesn't though which leads me to the second, that stuff could do with a squirt of Deoxit every 1 or 2 years. I've seen visible oxide buildup on stuff and it's still worked but good housekeeping dictates you should. Fwiw I don't work in a studio but have done bits with in such environments for friends who do ( 3 of the 4 are elec.engineers so know the score here where as I studied biochem so clearly out of my area although I do bits of audio on hobbyist level at most).

about a month and a half ago
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Ode To Sound Blaster: Are Discrete Audio Cards Still Worth the Investment?

K10W Re:No. (502 comments)

The /. writeup sounds like audiophile wank to me. I would be surprised if this Soundblaster could justify its price in a proper double blind study on real world data (music, games, movies, etc...) vs. the built in audio on your mobo.

That will be because it is audiophile wank. Dedicated cards have their place in some situations I admit the only potential truth in it is used to make totally wrong conclusion. Some boards have bad design with regards to signal path so you may get issues including interference with low impedance headphones (I noticed this on one machine with msi z77a g45) or the integrated doesn't have power to drive higher impedance ones (nor will most cards). Desktop amps exist for that reason or a cheap card like the xonar dgx (with uni drivers not official ones) may fix it as it did for me. The higher end discrete cards are BS along with all the marketing bollocks that go with them and are pretty much the same, any difference in sound comes down to a prefered sound from using different op amps usually.

As for sounding better if it wasn't double blind then placebo makes a hell of a difference and this has been proven many times. What has been found is driving high impedance phones properly can make difference in sound, so equal volume but 100% maxed out on one setup and 50% total volume on the other may actually result in different performance as as SOME devices distort more and have issues operating at highest end such as 95%-100% max output. Also slight volume increases are often percieved as "better" sounding, people will often score THE SAME headphones as higher than what they presume is another pair in blind tests just because they have been slightly turned up.

about a month and a half ago
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Police Recording Confirms NYPD Flew At a Drone and Never Feared Crashing

K10W Re:Yay big government! (310 comments)

Government, police, etc will always be corrupt. Always. People are people. The only defense is to give them just barely enough resources to do their job, with no excess or space for overreach. It's all about taxes - taxes are the only practical weapon the common voter has against government overreach, and the Constitution was written with this fundamental truth firmly in mind.

Of course, of all of Congress there are but a handful of congresscritters who actually are for less government spending, and usually the voter's choice is merely between which group of supporters the tax money will go to. That's a cultural problem in the US, and we can't begin to fix it until every call for lower taxes stops being dismissed with "you anarchist and probable racist, why do you want 0 government".

Fixing the problem starts with popular acceptance of the idea that one can say we're sending too much without being some extremist calling for the end of government. Less does not mean none - spread the word!

that wont fix anything, think a little bigger than national boundaries for the proof. Plenty of the worlds police turn to corruption to make a living because they have barely enough resources to do their job. The corruption doesn't stem from resources per se, just the way the corruption manifests changes whether it is on the side taxation/bribes/using resources to acting as a semi pmc or militia for various groups like in some developing countries to common thing in US and Europe of arrests for filling quotas to hit plotical projected figures and thus future funds as well as too much interests in getting fat of privatised prison system, sadly the UK is now going the same way.

about a month and a half ago
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MP Says 'Failed' Piracy Warnings Should Escalate To Fines & Jail

K10W Re:Totally clueless (135 comments)

The problem there is they might try start forcing more people in such prisons in order to make money for the government, claim "we are fixing this country" and everyone will cheer.

Do you not have private prisons in the UK? If not, I suppose it's only a matter of time. We have them in the US, and some judges are already rotting in prison for exactly the sort of thing you were imagining. They were sentencing juveniles with petty offenses to long term detention, in exchange for multi-million dollar kickbacks from the private detention facility. When imprisoning people becomes a profitable enterprise, abuse is guaranteed to follow.

Yeah Chris Grayling is indeed pushing DoJ that way, have friends involved in this mess who are leaving careers because of whole fiasco. They are trying to do that to the whole system not just 1 or 2 private prisons and judges here wont get put in such prisons for it since it'll be the system that is bent not just a few backhanders and dodgy practices which the met already specialises in getting away with to fluff arrest records to meet the projected figures the politicians want for that year. Basically everyone but the 1%club get shafted and they wreck our whole justice infrastructure, waste extraordinary sums on converting to a profit system that clearly wont work and can't be changed back once broken. I'm a reasonable guy who respects most but I don't consider tories sentient life nor valuable in any way for a reason

about 2 months ago
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$3000 GeForce GTX TITAN Z Tested, Less Performance Than $1500 R9 295X2

K10W Re:Wrong premise (151 comments)

These cards should have been tested from the perspective of high performance computing or scientific application.

5 insightful for complete BS? The nvidia quadro exists for that reason (or some applications tesla). GTX is FOR GAMES and totally unoptimised for cruching other data from 3d modelling/rendering, cad, vid encoding, compositing, scientific models/simulation etc etc. Price for price comparisons find the like of k2000 instead of gtx 780 would be better for none game. GTX work in some none game applications better but generally workstation cards beat them in most areas and software.

IIRC adobe premiere pro plays nicely and maybe better than workstation cards when talking price to price ratio in the budget end but workstation budget cards are not cheap. In fact the high end workstation cards make running 3 titans in SLI look cheap!

ATI firepro cards are similar but more toward specific 3D and CAD hence I never looked at them since quadro suits my needs better and are not meant to be ATI equivalent to quadro although they probably perform similar in many applications. I'd rather game on a £800 GTX than a £4200 workstation card aimed at DCC/CAD

about 3 months ago
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The Sci-Fi Myth of Killer Machines

K10W Re:Way to long to read. (222 comments)

I tried, honestly, but it's all bullshit. Assumptions. Without caring for reality. We now have robots that can decide to kill. Do we really want those? See what happened when you had drones shoot missiles at people? A lot of weddings got bombed. That is what happens when you take emotion out by relinking b&w video to an 'operator ' that pulls the trigger. Now imagine to take emotion out completely, because that is the direction we are heading. Especially, but not alone, the US. And the all other nations will have to follow. And as of now these systems exist and are being used in the field, as tests. Robots that decide who gets shot. Great fucking idea. Not.

actually many of the human rights people are arguing FOR AI for this very reason since it is logical and unemotional and less likely to hit civilians when used as shields and so on unlike humans who can conveniently leave out the civilians present when they put in the fire request with command.

Strike drones are bad comparison for genuine battlefield AI capable of making informed kills since their errors are mostly human operator whether it is lack of attention from boredom from working long shifts in sanitised environment to disregard for innocents to genuine mistaken IDs which are made on more human factors than logic.

about 3 months ago
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'Godfather of Ecstasy,' Chemist Sasha Shulgin Dies Aged 88

K10W Re:And thousands of candy ravers ... (164 comments)

I've never so much as tried marijuana or any other illegal drugs, any painkillers, nicotine, etc. The only drug I have experience with is alcohol.

Now, in my later years, my thoughts regarding intoxicants have changed. It's very interesting to m to read conversations like this--the experiences are so very far from my own. Even coming across these situations (e.g., talking about different kind of MDMA you see on a regular basis!) is far outside my ken. I had thought the Silk Road might be interesting to try--good thing I missed out, given what went down there.

I wonder if LSD will ever been legal within my lifetime. I kind of doubt it.

there is a fair bit of legitimacy coming back to LSD. I always considered it a potential ground breaking area of therapeutics. The whole street drug thing, Tim Leary and all the rest of that nonsense got a knee jerk reaction which led to it being dropped for therapeutic evaluation and Sandoz wouldn't touch it anymore with all the publicity and so on. It's more complex than this but still I feel we threw out a VERY promising class of therapeutic agents/method AND assistance in deep insights into cognition and so on.

Things are changing now and big inroads into an area of therapeutics are possible with human studies being authorised recently. MDMA is already producing good results in otherwise untreatable battle related PTSD as well as other things. LSD has so much to offer us I hope to see it legitimized for therapeutic use in my life if we get the research on how to use it effectively.

My biggest doubt is more the funding since developing therapeutics isn't where the money is, oncology gets more of the cash and other areas just left dry. That is the way the global pharma industry is I am afraid.

about 3 months ago
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Mozilla Ditches Firefox's New-Tab Monetization Plans

K10W Re:That's not who we are at Mozilla (195 comments)

laugh... but you would have gone ahead with it if you could have gotten it past the "community".

We need a new Firefox, someone "pure" again.

palemoon does a good job for me

about 4 months ago
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Brain Injury Turns Man Into Math Genius

K10W some truth in the bullshit pile? (208 comments)

from personal experience there may be some slight truths in it although most the stuff I've seen on him (came across before this article) looks like he's full of shit. I have diagnosed aspergers, I am high functioning but have savant traits and way above average IQ and it initially became apparent as a small child. I was born at 27weeks @ 2lb1oz and in hospital for 6months at birth, due to mistake of junior nurse who did something she wasn't qualified to do (feed me) my lungs got filled with milk (the tube was supposed to go in the other tube ;) ) and I stopped breathing for 7 to 8min. There is record of all this and parents confirmed they were told there would likely be damage to my brain due to way above the oft quoted 4min barrier as well as optic damage from the oxygen given.

So it seems the accident may have been the trigger for it although a lot more at play. The traits seem to run in minor form through one side of family all of whom are educated to high degree in maths/engineering/science and work in such fields as well as extensive hobbies within them but I am unusual in it is very exaggerated in me.

I am able to visualise mathematical and scientific theories in a way but it isn't as he describes. It is more like the same appearing object to sense organ but the conceptual object linked to it tends to have the physics etc of it linked in so I notice things naturally just seeing stuff that many wont without deeper thought. I found my studies easier due to this but it isn't special since anyone can train to do it it just doesn't seem to happen naturally in many cases. The seemingly intuitive nature is just deep familiarity and many many people have that.

about 4 months ago
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How To Find Nearby Dark Skies, No Matter Where You Are

K10W Re:I have experienced very dark skies (55 comments)

Heck, I dont even own a tripod.

You'd be surprised what you can mcguyver in a pinch, I'd still take your camera but curl up a jacket or something and rest cam on it on an angle, set to timer mode I've made do with that method when all I had on me was a compact. Could make 15sec stack a little trickier admittedly. Or pick up one of those $5 tabletop pods for compacts, don't take much weight but don't really need to. Rest it on a fence post, chair, car roof etc and it'll do the trick

about 4 months ago
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How To Find Nearby Dark Skies, No Matter Where You Are

K10W Re:I have experienced very dark skies (55 comments)

I have an uncle who owns a sheep station and (if all the house lights are turned off) the sky in that area is AMAZING. Its clear most of the time too (although I wish they had more rain, they really need it).

I hope to get back there sometime and stay with them again sometime and photography is something I intend to do if I do get out there (although I have no clue how well my little canon point & shoot would do with night sky photography).

it'll do 15sec at least, if it is CHDK compatible then the firmware upgrade will get you more options on long exposure. However limited to the 15sec max of most p&s you can take several on a tripod, use 2sec timer mode to avoid shake from touching shutter button. Then stack these photos in photoshop (or similar) with screen blendmode and you'll get the equivalent of longer exposure minus the noise as most is random. If you're really bothered you could take a few dark frames covering the lens (no cap per se with powershots I guess) and subtract from the light frame data if hotpixels are an issue.

I mainly use an entry level dslr and a prosumer end dslr both with high quality fast glass, rock solid tripod and so on for astro work as a big hobby of mine but it is surprising what you can get out of a point and shoot, so much I converted an old bridge camera to IR by whipping out the hotmirror as more DSO's are visible then when stack in likes of DeepSkyStacker or Registax and their ilk.

Hope it helps, high end gear isn't needed for a lot of fun with astro photography and pretty impressive results. Although admittedly you wont get mind blowing stuff without decent tracking rig, dslr that is IR modded (and I see some who go DIY peltier cooled route as well) and scope, H-alpha filters etc. those things are still not very expensive if you ever chose to go that way in future.

about 4 months ago
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Bill Gates & Twitter Founders Put "Meatless" Meat To the Test

K10W Re:Not all vegetarians would like vegetarian meat. (466 comments)

How it got that way is that meat is tasty and provides a lot of energy. People are so fervently against giving up meat because the substitutes that have been put forth (tofu, soy) generally suck in most forms people consume them in. Yes you can kind of make Tofu tasty with some work (though personally I've never had tofu elevated beyond "edible"), but you have to do nothing to a chicken breast to make it tasty other than cook it.

If this mean substitute is actually tasty and the texture is not horrifically awful (most of the supposed meat substitutes ignore that aspect) then in fact a lot of people probably would be OK using it.

Your main problem, as with so many other things in ilife. will be environmentalists since it's not "natural".

unless things have changed since my time (biochem degree in late 90's so quite possible it has so I'm open to correction) most meat isn't that great nutritionally and I don't mean the mechanically separated stuff either. Things are ranked by amino acid content and how bio available they are and a lot of meat doesn't score too high, beef is higher than most but quorn is significantly higher. I am vegetarian and have been vegan on and off for years since teens and I admit quorn is good despite not eating it, I HATE the claim soya good substitute. Soya is much lower than most meat, very hard to get what we need from it and pretty much just glycine, probably explains the naming of common species of it.

Quorn is higher than all the meats I saw and close to the highest reference of eggwhite (cooked). Even more so since they bind the fungal hyphae with eggwhite. It has too much RNA iirc so they have to blitz it with UV but it is fine after that. Fwiw I don't actually eat meat substitutes and prefer vegetable based foods from a wide range of cultures; although I am fond of homemade seitan I admit it isn't good for celiacs. You're on the money with the "not natural" crowd though since they tend to be pretty ignorant of the science of it and dislike it based on "not natural" ideals

about 4 months ago
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Bill Gates & Twitter Founders Put "Meatless" Meat To the Test

K10W Re:But the price? (466 comments)

Why is meat so cheap compared to vegetables when you need several times as much vegetables to feed the animals for the same abount of nutricion. Logic would say that vegeatians would be a financial choice. It is the same in Europe.

economies of scale also come into it, some veg are cheaper than meat but most veg products marketed as meat substitutes are small market. Some are bigger than expected with portion of health market and kosher markets but they are still niche.

about 4 months ago
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UAV Operator Blames Hacking For Malfunction That Injured Triathlete

K10W Re:Evolution (178 comments)

Reads like bullshit anyway. Something went wrong, he throws up the "it wasn't me it must be those evil hackers" defence rather than accepting the blame for putting his device together poorly or letting it go out of range. There would be no way of knowing for sure if another device took control during the incident (because who would build that in to a home made UAV), so he *may* be telling the truth, but if it happened twice in one day either someone is out there deliberately hashing the channels to mess with everybody, or he just went out of range/did something wrong/etc.

nah I doubt he is telling the truth, many are designed to lose signal and be ok hence they will hover and wait for signal or some come back to you and land (within 20ft radius or whatever for many hence you DON'T launch it from a position with trees around). Also I know a couple of drone flyers where I live and they tend to know all the others in the community who fly, what models they have and tweaks to them even and this is a large city!

So the hacked thing is crap and if someone did do so earlier in the day he'd likely know the person responsible if they were in range with a low power device to do so. He just needs to cowboy the fuck up and admit his mistake.

about 5 months ago
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First LSD Test In 40 Years Reveal Drug Helps Terminal Patients Prepare For Death

K10W Re:bad trip to the power of infinity? (221 comments)

I've had very few bad "trips" but I can't imagine how bad it could be if you know you are dying.

Knowing you're dying can be a bad trip, no drugs required. Someone who's looped their fear until their soul is crushed isn't in much danger - they've already hit bottom.

Knowing you're going to die is a terrible burden, but it presents you the opportunity to choose the last memories your friends and family will have of you. They can remember you living your last weeks in fear and dying terrified, or you spending some time recalling the good times, and perhaps forgiving some of the bad ones. That's all the control you have left of your legacy, and you don't have much time to take advantage of it.

LSD, especially low* doses with someone to help guide can sometimes give people a new perspective. If they can relax their fixation on the fact that their time is up they may see the bigger picture - that we're all mortal, that life is a cycle, and that this is just a part of it. It may give you the opportunity to make your peace with the world. And if not, you're dead anyway. So why not?

* There's adequate margin between free-association, preconception-questioning levels and moon-howling-naked.

sooo many people jump to the conclusions therapeutic doses are same as recreational, finally someone with a clue, wish I had mod points. The therapeutic doses are often barely noticable compared to rec ones

about 6 months ago
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First LSD Test In 40 Years Reveal Drug Helps Terminal Patients Prepare For Death

K10W Re:Is this even news? (221 comments)

This is really ancient knowledge. Did science just get hep? Great.

It's more about science getting approval. LSD is one of those compounds that is next to impossible for researchers to get access to and test in humans. For reasons I don't care enough about keeping kids off drugs or something to fully understand, some drugs are so wicked and dangerous and illegal that it is necessary to prevent any research (even about how dangerous they are; but definitely nothing suggesting that they aren't as dangerous as previously believed), even under hardass conditions, on terminal patients, and so forth. As quoth noted toxicologist and psycho-pharmacologist Jacqui Smith: "You cannot compare the harms of an illegal activity with a legal one." Why? Because one is illegal, of course! I wouldn't really call this 'ancient knowledge' (if the first synthesis was in 1938, it probably isn't shamanic lore); but it was certainly an active area of scientific interest pre-ban. That somebody would want another crack at it isn't even remotely news. That they managed to fill out the paperwork, on the other hand...

so true, been waiting for this for a while as it's been on the potential high therapeutic benefit list for some time, Tim "f**king" Leary as well as the ott governmental policies wipe so many promising agents off the potential breakthrough research lists. MDMA is coming into it's own with the fruition of trials for successful treatment of battle induced PTSD where not much else worked.

I remember surprise as a youngster what we could order from the suppliers no problems never mind what we could make, and yet so many things much less damaging including LSD placed in the restricted section of our labs catalogue required soooo much paperwork you'd never get it approved it'd never happen for human use

about 6 months ago

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