Beta
×

Welcome to the Slashdot Beta site -- learn more here. Use the link in the footer or click here to return to the Classic version of Slashdot.

Thank you!

Before you choose to head back to the Classic look of the site, we'd appreciate it if you share your thoughts on the Beta; your feedback is what drives our ongoing development.

Beta is different and we value you taking the time to try it out. Please take a look at the changes we've made in Beta and  learn more about it. Thanks for reading, and for making the site better!

Comments

top

Doctors Will Test Gene Editing On HIV Patients

KungFuSoi Re:might as well guinea pig at that point (263 comments)

just as in cancer or other infectious diseases, the natural selection placed on the hiv population within the patient by therapy (haart) will make it likely for the emergence of drug-resistant strains. thus, even patients who do not have drug-resistant strains of hiv will benefit if this therapy is a success.

of course, one cannot be sure that the selection pressure exerted by the t-cells with the ccr5 (\delta 32?) deletion will not result in hiv strains capable of invading t-cells via a new mechanism.

more than 5 years ago
top

Bacteria Make Major Evolutionary Shift In the Lab

KungFuSoi Re:not much evolution here I fear (1185 comments)

i agree with you that the post above is not insightful; however, i will disagree that humans have a higher mutation rate than e.coli. humans have much more accurate error correction machinery than bacteria.

http://www.genetics.org/cgi/content/full/156/1/297

however, the previous post is not insightful for a multitude of reasons. the crucial error is that the anonymous coward is not taking into account various evolutionary forces. the citrate mutation could have appeared and disappeared by chance (genetic drift) multiple times if the citrate metabolism gene did not confer enough of an advantage (generally it has to be s > 1/N, where s is the advantage and N is the population). so the simple arithmetic while adorable, is deeply ignorant. to edify, get this from your library...

http://www.amazon.com/Population-Genetics-John-H-Gillespie/dp/0801880084/

more than 6 years ago

Submissions

KungFuSoi hasn't submitted any stories.

Journals

KungFuSoi has no journal entries.

Slashdot Login

Need an Account?

Forgot your password?