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Comments

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Alcoholism Vaccine Makes Alcohol Intolerable To Drinkers

Kurofuneparry Summary doesn't know what enzyme is (350 comments)

It uses enzyme when it means substrate. The enzymes make the changes, they are not the things changed.

...idiot....

about a year and a half ago
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Watson Goes To Medical School

Kurofuneparry Re:Exactly What American Med Schools Want (100 comments)

Fourth year medical student here.

The comments above are quite true and in no way exaggerated. Being a good physician after passing the USMLE or COMLEX is mostly coincidence. Then again ... I'm an idiot ....

about 2 years ago
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Gut Bacteria Cocktail May End Need for Fecal Transplants

Kurofuneparry Not like any yogurt (183 comments)

Med student here, just attended three meetings on this condition, and I've had a number of patients with this condition.

This kind of treatment has been tested before and is an exciting possibility, but there have been failures in the past. Also, this is nothing like the yogurt cultures you know.

......... then again I'm an idiot .........

about 2 years ago
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Scientists Turn Skin Cells Into Beating Heart Muscle

Kurofuneparry Re:A question for the bio geeks.. (121 comments)

You, sir, win all of the internets.
... Then again .... I'm an idiot .....

more than 2 years ago
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Scientists Turn Skin Cells Into Beating Heart Muscle

Kurofuneparry Re:A question for the bio geeks.. (121 comments)

While you are correct about many of the concerns from the stemming process, I was mainly talking about somatic mutations (like those caused by gamma radiation for example). The statement I made previously about these somatic mutations propagating no more in stemming than in breeding is still true. Also, the proto-oncogene concern is one that current research is already working toward limiting.
My main concern with your statement is the argument that stem cells are MORE susceptible to random mutation than somatic cells. This is simply false. You argued that decreased activity is a protective attribute than for stem cells. In fact, most stem cells in the human body are LESS active than somatic cells as somatic cells do the work and (monopotent) stem cells like osteoprogenitor cells are mainly there to replenish and preserve genetic information. It's a biological axiom that sex cells (sperm and ova) have the highest importance in preserving genetic integrity and that's what we see experimentally: the sex cells have BETTER preservation of information, not worse.
.... Then again ..... I'm an idiot ....

more than 2 years ago
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Scientists Turn Skin Cells Into Beating Heart Muscle

Kurofuneparry Re:A question for the bio geeks.. (121 comments)

Biochemist medical student here. Propagating genetic errors is certainly a concern here, but the same concerns exist for genetic transfer in breeding generally. While skin cell are exposed to more radiation, the cells preferred for sampling here are typically from buccal (mouth) sources or are relatively deeper than the layers where most melanoma form.
Honestly, the more prime concerns are with imperfect "stemming" or imperfect conversion to heart cells.
Then again ... I'm and idiot ....

more than 2 years ago
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Ask Slashdot: What Language Should a Former Coder Dig Into?

Kurofuneparry Re:Python (530 comments)

Forget the arguments against dynamic languages because you said you're doing this as your own project.
Forget the arguments for javascript because you're asking for a language to 'become native to'.
The Python language is great and community is awesome.
Then again... I'm and idiot.....

more than 2 years ago
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Mild Electric Shock To Brain May Boost Spatial Memory

Kurofuneparry Re:Calling 'shock' or 'electroshock' inaccurate (65 comments)

Yes, in the sense that they're using it to try to determine which parts serve which function. Certain areas are dependent on the function of other areas, like Broca's area (mouth articulation for speech) being dependent on Wernicke's area (Word association/searching).

Then again.... I'm an idiot.....

more than 2 years ago
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Mild Electric Shock To Brain May Boost Spatial Memory

Kurofuneparry Calling 'shock' or 'electroshock' inaccurate (65 comments)

This is deep brain stimulation. They're running a constant or alternating current, not producing bursts of electricity or a 'shock'. I've administered the modern, anesthetized, calibrated version of electroshock in my medical training and this procedure described here is also very, very different.

This is much more analogous to overclocking a part of the brain by preferentially stimulating it to work harder. This may be used to improve performance but those applications are still far away. This is most useful as a diagnostic tool or even more likely as a research tool to try to understand what various parts of the brain do.

Then again.... I'm an idiot.....

more than 2 years ago
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Muslim Medical Students Boycott Darwin Lectures

Kurofuneparry Re:Good (1319 comments)

This is ignoring the point of the objection: Some pharmacists believe that the morning after pill is murder and that filling it just because it's their job is akin to soldiers in various atrocities saying that they were just following orders.
Also, you seem to have misunderstood the post to which you were responding. They were agreeing with you.
Then again..... I'm an idiot....

more than 2 years ago
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US Defunds UNESCO After Palestine Vote

Kurofuneparry Re:How about not admitting terrorist groups (735 comments)

Really? It seems with reports of shiite and suni violence from the official thugs in many middle east countries that Isreal would be the best country to support. Their record for religious freedom for Muslims beats that of their neighbors.

Certainly both sides have made many mistakes but putting Hamas beside the Isreali government shows that they're not even in the same league. Supporting Isreal and expecting any others to recognize their right to live is a fundamental requirement for peace in the middle east if they're willing to have it.

Then again.... I'm an idiot....

more than 2 years ago
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Climate Change Skeptic Results Released Today

Kurofuneparry A co-researher disagrees (776 comments)

Another researcher working on the same project seems to disagree. Judith Curry is the second name on the paper according to the daily mail and she's contesting the analysis of his own data as incorrect with some rather strong language.

Then again.... I'm an idiot.....

more than 2 years ago
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Wealthy Americans Turning To Europe For Medical Treatment

Kurofuneparry Re:This can't be true! (519 comments)

Cuba has also been known to drop some off of reports and only serve a limited, privileged class. It's very easy to have great bang for the buck when you limit the bucks and only serve the ones you'd rather serve. Such a proposition isn't effective in a nation 'by and for' the people.

more than 3 years ago
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Wealthy Americans Turning To Europe For Medical Treatment

Kurofuneparry Re:This can't be true! (519 comments)

Very poor methodology. The US actually has the best, what you're thinking of is 'best per cost'. That's very different. We're willing to pay for all kinds of treatments that aren't available in Cuba.

If I were sick, I would want to be treated in the country that had the best absolute results, not the one that spent minimally. If I were very sick, I would want to spend every effectual dollar, not just the ones that a bureaucrat approved.

more than 3 years ago
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Wealthy Americans Turning To Europe For Medical Treatment

Kurofuneparry Re:religion (519 comments)

Why on earth does this get points for insightful?

This really isn't the issue. The treatments as given in the US are generally as good or better, with prostate cancer numbers being one of the classic examples.

The real issue is that the FDA in the US is comparatively slow and over-cautious in allowing these alternative treatments. In other words, the problem is that the US has over-regulated healthcare presently and we would have the same advantages that the rich seek in Europe if we had more deregulation.

Of all of the doctors that I've rotated with in medical school, each one that has spoken of the FDA has shared this opinion. Then again.... I'm an idiot...

more than 3 years ago
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Mac Users More Liberal Than Windows Users

Kurofuneparry Re:Distasteful (638 comments)

There are two kinds of people: those who divide the world into two kinds of people, and those who don't. I'm one of the latter. (Jim Blinn)
Then again, I'm an idiot....

more than 3 years ago
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Graphene Super Paper Is 10x Stronger Than Steel

Kurofuneparry Re:Rate of degrading? (244 comments)

In college chem we had to do this same problem. Basically, at any normal temperatures and pressures you could break high level encryption by brute force methods sooner than notice any change in the diamonds weight by conventional methods.
Graphite is very similar to diamond in this. Technically the reaction is favorable but the kinetics don't work..... then again, I'm an idiot.....

more than 3 years ago
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Medicines Lose Effectiveness In Space

Kurofuneparry Re:News? (116 comments)

The job of NASA's physicians was to not allow astronauts into space if they were at all unhealthy. Even a suspicion of a coming flu was enough to ground an astronaut from a mission they'd spent years preparing for. Thus, medication has rarely been required in space and tests in space have always been limited and expensive. Then again.... I'm an idiot.....

more than 3 years ago
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Medicines Lose Effectiveness In Space

Kurofuneparry Re:Paracetamol tablets? (116 comments)

As I responded elsewhere in the comments:

We needn't think that microgravity affects chemical compounds to explain this. Many more gross physical quantities are often dominant in the effects of drugs. For example, bioavailability (absorption) of drugs can dominate with digoxin, aspirin etc. Thus changing GI motility is a big issue and could be affected by a lack of gravity. We STILL don't know how our GI tract separates gas from liquid and this could easily be gravity dependent.

Other systems dependent on gravity include veins (the return of blood is gravity dependent especially in the legs) and lymphatic pumping (which is mainly motivated by eccentric/isometric or various contractions of the muscles that occur less in space. For many drugs the limiting factor is proper dispersal in the body (e.g. haloperidol, NSAIDS, antibiotics). Then again, I'm an idiot medical student.......

more than 3 years ago

Submissions

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Climate researcher Mann suing journalist Steyn for libel

Kurofuneparry Kurofuneparry writes  |  about 2 years ago

Kurofuneparry (1360993) writes "National Review journalist Mark Steyn has announced that he is being sued by Penn State climate research Michael Mann over an article that attempted to connect Penn State's handling of the Jerry Sandusky rap case to the handling of a review of Mann's work. The letter provided by Mann's lawyer is presently available.

This is a move likely to keep the debate on climate change simmering and tempt the Streisand effect. From the offending article, "If an institution is prepared to cover up systemic statutory rape of minors, what won’t it cover up? Whether or not he’s 'the Jerry Sandusky of climate change', he remains the Michael Mann of climate change..." The letter from Mann's lawyer hinges on an argument that the "... allegation of academic fraud is false, and was clearly made with the knowledge that it was false.""

Link to Original Source
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Borat used for Patent prior art

Kurofuneparry Kurofuneparry writes  |  more than 2 years ago

Kurofuneparry (1360993) writes ""Rarely does patent law meet pop culture so hilariously. But it gets to a more important point: An invention cannot be patented if there has been a public disclosure of said invention prior to the date of filing." Not exactly a tech patent, but it does comically display the kind of prior art searches that are often being done so poorly in the tech industry by the over-burdened patent office. After talking about how a "scrotal support garment" patent is invalidated by the Borat movie, the article also mentions a case involving Apple last year as well as a case in which the Bible was used for prior art."
Link to Original Source
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Colleague says Climate Research does not Prove Ske

Kurofuneparry Kurofuneparry writes  |  more than 2 years ago

Kurofuneparry (1360993) writes "Judith Curry, a climate researcher working with Richard Muller who's research is mentioned on slashdot today, has claimed that his published conclusions that recent research disproves skeptics is a 'huge mistake'. Also, "‘There is no scientific basis for saying that warming hasn’t stopped... To say that there is detracts from the credibility of the data, which is very unfortunate.’ She also compares this disagreement in analysis to the previous Climategate scandal."
Link to Original Source
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US Senator introduces internet sales tax bill

Kurofuneparry Kurofuneparry writes  |  more than 3 years ago

Kurofuneparry (1360993) writes "Given recent stories of Amazon pulling out of states that attempt to tax sales, there is now a national attempt to impose sales tax in the US.
Article: "Why should out-of-state companies that sell their products online have an unfair advantage over Main Street bricks-and-mortar businesses?" Durbin said in a speech in Collinsville, Ill., in February.
For those unfamiliar with US law, states are not allowed to tax business transactions in other states or across state borders. Taxation reform is seen as either a leveling of the playing field or a further encroachment of government taxation."

Link to Original Source
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Streaming audio/video to be specified as illegal

Kurofuneparry Kurofuneparry writes  |  more than 3 years ago

Kurofuneparry (1360993) writes "Convinced that the right direction for the copyright/piracy debate is more governmental power and enforcement, White House admin Victoria Espinel is seeking sweeping new powers for enforcement: "The White House is concerned that "illegal streaming of content" may not be covered by criminal law, saying "questions have arisen about whether streaming constitutes the distribution of copyrighted works." To resolve that ambiguity, it wants a new law to "clarify that infringement by streaming, or by means of other similar new technology, is a felony in appropriate circumstances."" The real question is, will this help at all?"
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Calls for patent reform receiving more attention

Kurofuneparry Kurofuneparry writes  |  more than 3 years ago

Kurofuneparry (1360993) writes " The US politics website Politico is running a story about calls for patent reform from venture capitalists. From the article "Though patents were created to encourage innovation, a growing number of investors say the patent system actually stifles it. In the fast-moving software market, where online applications are constantly changing, investors say software patents are often targets for lawsuits rather than protection from them." Large businesses are often the perpetrators of patent abuse so it's refreshing to hear businessmen using terms similar to those often seen here on slashdot."
Link to Original Source
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Apple Deprecates Java

Kurofuneparry Kurofuneparry writes  |  about 4 years ago

Kurofuneparry (1360993) writes "Apple has announced that Java is deprecated as of the most recent update to OS X. This shot across the bow is getting some responses. To Jobs claim that "Sun (now Oracle) supplies Java for all other platforms" Gosling is quoted as saying that "simply isn't true". Much talk of a coming turf war is to be had. This certainly can't be unrelated to statements from Jobs recently covered on this website and is sure to make waves. Apple has enjoyed significant success recently accompanied by a widespread sense that they can do no wrong in business or design. However, is deprecating Java a mistake? It doesn't take much insight to connect the dots and see that Apple has starting marking friends and enemies relative to the increasingly heated fight for mobile and other platforms."
Link to Original Source
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A likely key to rhesus monkey HIV immunity

Kurofuneparry Kurofuneparry writes  |  more than 4 years ago

Kurofuneparry (1360993) writes "In biochemistry seminary I learned that some humans and rhesus monkeys generally seem to be immune to the HIV pathogen. The puzzle has been a 'holy grail' and may have just been solved: "Loyola researchers have identified six (6) individual amino acids, located in a previously little-studied region of the TRIM5a protein, that are critical in the ability of the protein to inhibit viral infection." While the title of the article is wrong (they didn't discover the protein, just some of it's nature in rhesus), this discovery is a major step forward along one of the few present hopes for an HIV/AIDS cure. Let the puns about 'rhesus pieces of sequences' ensue..."
Link to Original Source

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