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Your Phone Can Be Snooped On Using Its Gyroscope

macklin01 Re:The paper says... (96 comments)

It would be neat, however, to see gyroscope inputs added to regular audio inputs to improve speech-to-text. This seems to be a nice proof of concept for that.

about 3 months ago
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Ask Slashdot: How Often Should You Change Jobs?

macklin01 Missing part of the summary (282 comments)

It's not just that people can "write their own tickets", but that promotions and raises seem to happen much more at time of hire than after good performance. Work on that and there might be a lot less churn ..

about 5 months ago
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Unintended Consequences For Traffic Safety Feature

macklin01 Re:Not for deaf/hard of hearing... (579 comments)

I've encountered these, and I'm told they're pretty loud.

I'm a fairly young guy (37 yo) with perfect hearing below about 1500 Hz, and almost zero hearing above 2000 Hz. To me, these loud clicks are tough to hear unless close up.

I run into the same problem with high-pitched fire alarms (most of them), the "you left your headlights on" beep, seat belt beeps, kitchen timers, the little beep on my FasTrak transponder, etc.

This is probably a widespread problem--we tend to lose hearing in the higher frequencies first. The solution isn't to use annoying high pitches and make them louder; the solution is to use broader frequencies or use lower pitches that more people can hear.

Please keep this in mind when you're considering using a little chirpy piezoelectric in your next circuit project ...

about 5 months ago
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545-Person Programming War Declares a Winner

macklin01 Re:Interdisciplinary crossover (57 comments)

BTW, that's a very cool paper! Have you considered using these techniques towards image processing, segmentation, etc.?

about 5 months ago
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Strange New World Discovered: The "Mega Earth"

macklin01 17 more massive = mega earth? (147 comments)

Shouldn't this be 1.7 decaearths?

Since the sun is about 333 kiloearths in mass, wouldn't a megaearth be about 3 solar masses? :-)

about 6 months ago
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Ultrasound Technique Provides a New Radiation Free Way To Visualize Tumors

macklin01 Re:'Radiation Free' (35 comments)

I suspect the real story here is likely finding a good target (SFRP2), more so than the microbubbles. Finding a specific enough target always seems to be the limiting factor in immunotherapy, nanoparticle-based drug delivery, GNP-based radiothermal therapy, etc.

Now if they could find a good target for more cancers (I definitely agree on breast as a good target--elastography ultrasound is already a big topic of interest there), it could have a nice impact on treatment options. Since you can't really image too frequently by MRI, CT, etc. due to exposure limits, you can't do high-frequency watchful waiting, which biases clinicians and patients towards intervention when they detect something.

In breast cancer, this is a pretty hot topic: all these frequent / early mammograms are detecting lots of DCIS, and the standard thing to do is lumpectomy. But there's growing evidence that these are likely being overtreated, and many if left alone would likely not progress to invasive carcinoma for a long time. But since there's no great way to know on a patient-by-patient basis, and since you can't really keep a close eye on them by frequent imaging, it's tough to do otherwise.

But if you could image the breast cancer really well by ultrasound, you could do such a watchful waiting: image frequently, and so long as there's no change, keep monitoring. (Not sure if this would have have the resolution to detect an in situ cancer like DCIS, though. Will have to read the article.) It would be nice to see such watchful waiting options open up for other cancers where treatment choices are perhaps otherwise unclear.

I've also seen early work attempting to use interference patterns in ultrasound (putting a few piezoelectric membranes at the right spacing, etc.) to induce apoptosis at specific spots. It would be interesting to see if this work could help enhance that ...

about 10 months ago
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3D Printing of Human Tissue To Spark Ethics Debate

macklin01 Re:3D Printing is too complex. There is an easier (234 comments)

I disagree with a lot of the parent's post, but this part is reasonably solved. When you decellularize an ECM, the vessel walls remain intact. Then you reseed with HUVECs (an endothelial cell line), and they tend to find their way back onto the old vessel walls to form a vasculature.

But you are absolutely right that the microarchitecture of the tissue is very, very significant to proper function.

about 10 months ago
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3D Printing of Human Tissue To Spark Ethics Debate

macklin01 Re:3D Printing is too complex. There is an easier (234 comments)

While the ECM molecular components are conserved as you point out in another post, their distribution (e.g., how much collagen IV, matrix-embedded glycoproteins, etc.), stiffness, and microarchitecture vary quite a bit from species to species, organ to organ, and even individual to individual. And this radically affects the phenotype of the cells that you transplant on them. Both cancer and "normal" epithelial cells are known to change their motility, proliferation, and even polarization characteristics based upon the stiffness of the tissue, for example.

And take a look at livers: pig livers have a very thick membrane between hepatic lobules, making them great for textbooks, as you can very clearly see portal triads and central veins and the overall lobular outlines. Human tissue, by contrast, has very thin membranes between lobules that can scarcely be seen in H&E pathology. This makes pig liver ECM a very poor starting point for growing a human organ replacement. When our collaborators build bioengineered liver tissue, they actually start with decellularized ferret livers because their structures are closer to humans than pigs.

This is why a mix of 3-D printing and seeding progenitor cells could be promising in the future. If you could 3-D print the ECM to have the correct spatial distribution and mechanical properties, you'd have a much better starting point when you seed them with progenitor cells to grow the epithelium / parenchyme, HUVECs to grow the vessels, etc.

Aside: I have yet to see XCM in 10+ years of cancer research and tissue biomechanics work. It's ECM.

about 10 months ago
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Stephen Wolfram Developing New Programming Language

macklin01 Re:His next project is interesting (168 comments)

Wolfram announced his latest idea - that there needed to be some kind of pliable material available next to toilets with which to clean one's bum. This material, he said, is going to be really soft, probably a couple of layers thick, and needed to be on some kind of continuous dispenser mechanism which he is developing.

And naturally, he'll call it Wolfram paper. :-)

1 year,8 days
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Google: Our Robot Cars Are Better Drivers Than You

macklin01 Re:Data will get you jailed (722 comments)

I figure there needs to be something similar to the National Vaccine Injury Compensation Program: here, something that makes society safer overall (vaccines) is promoted by reducing the risk of an individual harm (a rare side effect). This says: "Pay in and help make society safer, and if it individually harms you, we've got your back."

So, why not something for driverless cars? You opt into a driverless car with the societal benefit of reduced accidents, and if your driverless car harms you individually (physically or legally), the national defense fund takes over.

1 year,28 days
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NHTSA and DOT Want Your Car To Be Able To Disable Your Cellphone Functions

macklin01 Re:Driver not the only one in the car (405 comments)

Furthermore, the passenger might be helping with the navigation, answering those critical emails, etc ... to help the driver keep focused on the road.

about a year and a half ago
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The Balkanization of Chatting

macklin01 Re:iPhone and "txt" messages (242 comments)

this and this are pretty similar. I see this most frequently in multi-person text messages from iPhone, and indeed, in the default txt message client, these often appear as attachments / multimedia instead of text.

about a year and a half ago
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The Balkanization of Chatting

macklin01 Re:iPhone and "txt" messages (242 comments)

Good point. Since I've seen this issue sporadically with multiple iPhones sending messages to Android, I had figured it was more on the iPhone end with a standards-breaking or standards-bending SMS behavior.

about a year and a half ago
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The Balkanization of Chatting

macklin01 Re:iPhone and "txt" messages (242 comments)

BitZtream (692029) wrote: That doesn't happen on iPhones, perhaps its your end thats the problem.

theurge14 (820596) wrote: Sounds like it might be a problem on your phone. I haven't seen this problem at all on iPhones.

[snark]Of course the standards-breaking message sender renders its standards-breaking messages correctly.[/snark]

More seriously, we have:

  • iPhone -> iPhone : no problem
  • non-iPhone -> iPhone : no problem
  • non-iPhone -> Android : no problem
  • iPhone -> Android : textual messages appearing like multimedia attachments

This suggests that iPhone is using iChat or similar to "txt" with other phones and encoding outgoing info in some sort of multimedia or attachment tags within the SMS format.

about a year and a half ago
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The Balkanization of Chatting

macklin01 iPhone and "txt" messages (242 comments)

I can't stress enough how much it drives me up the wall to get text messages on my Android phone from iPhones. Far too often, they show as "multimedia" messages requiring a data connection just to download 5-7 words of text.

Or when an iPhone user sends a txt message to several people, and each "reply to all" response appears as a separate, disjoint SMS thread without the full conversation or context.

about a year and a half ago
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Developers Begin Hunt For a Killer App For Google Glass

macklin01 Re:Privacy and etiquette (155 comments)

The "universal translator" idea had crossed my mind, too. ;-)

about a year and a half ago
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Developers Begin Hunt For a Killer App For Google Glass

macklin01 Re:Privacy and etiquette (155 comments)

Personally, as a guy with hearing loss that's really cutting into those handy consonant sounds above 2000 Hz, I'm thrilled at the idea of real-time "closed captioning" placed under each speaker. Right now, noisy restaurants and lectures can be a bit of a nightmare, even with top-of-the-line hearing aids.

about a year and a half ago

Submissions

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Sept 14 is red letter day: Black Mesa Half-Life rewrite to be released!

macklin01 macklin01 writes  |  more than 2 years ago

macklin01 writes "Sep. 14 is red letter day: after 8 years of development, the third-party "Black Mesa" rewrite of Half-Life is finally going to be released. This re-writes the original Half-Life with the HalfLife2 Source engine, along with significant improvements to the graphics and soundtrack. While you're waiting, you can look at recent screenshots (and a few videos here and there, such as here) and download the soundtrack (and donate!) to whet your appetite. So go on: they're waiting for you in the test chamber, Gordon!"
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