Back in the day most applications with some sort of copy protection would load everything at once into memory. If your computer had a memory expansion port you could attach an ICE device to the memory expansion port, do a memory dump to it, write out the memory dump to disk and voila! you have a broken copy of that application. Is there an analog to this today?
Firewire DMA, which can be used to snag the encryption key for various DRM schemes (though you usually don't have to go to such lengths). There are also similar devices intended for forensic use.