Working while traveling isn't high on my list of priorities. Watching an episode on Netflix, playing a VR racing game (admittedly slower on the highway than on the track), whatever.
And the comfort level will get there. The first generation will only be a little bit better than human reactions. The next version (hopefully a free software upgrade - funded by an auto-manufacturer/insurance alliance) twice as safe, the next version four times as safe, etc.
If it can't just be software upgrades, it's going to be a long, slow adoption: cars get replaced every 2-10 years - but then they get resold, so the average age of cars on the road is over 11 years.
Eventually, insurance lobbies will get the government to require autonomous driving: first on certain highways and city centers, then eventually everywhere. Just like seat belts, air bags, rear-view cameras.